Photoperiodic effects on body mass, energy balance and hypothalamic gene expression in the bank vole

W L Peacock, E Krol, K M Moar, J S McLaren, J G Mercer, J R Speakman

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We examined the effect of increasing photoperiod, at a constant low temperature, on the body mass and energy budget of the bank vole Clethrionomys glareolus. Simultaneously, we determined the hypothalamic gene expression of neuropeptides and receptors known to be involved in short-term energy balance. Despite an increase in body mass (approximately 10% of initial mass), we found no significant changes in any energetic parameters (food intake, energy assimilation rate, resting metabolic rate and total daily energy expenditure by doubly-labelled water). Apparent energy assimilation efficiency was higher in voles exposed to long-days (LD) compared to short-days (SD). Surprisingly, gene expression of corticotrophin releasing factor (CRF; in the paraventricular nucleus), and the melanocortin-3 receptor Summary (in the arcuate nucleus), both known to be involved in appetite suppression and elevation of energy expenditure in short-term energy balance, were higher in voles kept in LD compared to SD. CRF expression was also elevated in females compared to males. These paradoxical data suggest an alternative mechanism for the control of seasonal body mass changes compared to short-term body mass changes, and between male and female voles. Furthermore, they highlight the need for studies to perform simultaneous measurements at both the molecular and whole animal levels.

Original languageEnglish
Pages (from-to)165-177
Number of pages13
JournalJournal of Experimental Biology
Volume207
DOIs
Publication statusPublished - 2004

Keywords

  • seasonal adaptation
  • resting metabolic rate (RMR)
  • daily energy expenditure (DEE)
  • doubly-labelled water (DLW) technique
  • hypothalamic neuropeptides
  • Clethrionomys glareolus
  • bank vole
  • CORTICOTROPIN-RELEASING HORMONE
  • RESTING METABOLIC-RATE
  • FOOD-INTAKE
  • SIBERIAN HAMSTERS
  • NEUROPEPTIDE-Y
  • MICROTUS-PENNSYLVANICUS
  • COLLARED LEMMINGS
  • STRESS-RESPONSE
  • LEPTIN RECEPTOR
  • MESSENGER-RNA

Cite this

Photoperiodic effects on body mass, energy balance and hypothalamic gene expression in the bank vole. / Peacock, W L ; Krol, E ; Moar, K M ; McLaren, J S ; Mercer, J G ; Speakman, J R .

In: Journal of Experimental Biology, Vol. 207, 2004, p. 165-177.

Research output: Contribution to journalArticle

@article{7fae717c068e411a8ecb79bd125896e2,
title = "Photoperiodic effects on body mass, energy balance and hypothalamic gene expression in the bank vole",
abstract = "We examined the effect of increasing photoperiod, at a constant low temperature, on the body mass and energy budget of the bank vole Clethrionomys glareolus. Simultaneously, we determined the hypothalamic gene expression of neuropeptides and receptors known to be involved in short-term energy balance. Despite an increase in body mass (approximately 10{\%} of initial mass), we found no significant changes in any energetic parameters (food intake, energy assimilation rate, resting metabolic rate and total daily energy expenditure by doubly-labelled water). Apparent energy assimilation efficiency was higher in voles exposed to long-days (LD) compared to short-days (SD). Surprisingly, gene expression of corticotrophin releasing factor (CRF; in the paraventricular nucleus), and the melanocortin-3 receptor Summary (in the arcuate nucleus), both known to be involved in appetite suppression and elevation of energy expenditure in short-term energy balance, were higher in voles kept in LD compared to SD. CRF expression was also elevated in females compared to males. These paradoxical data suggest an alternative mechanism for the control of seasonal body mass changes compared to short-term body mass changes, and between male and female voles. Furthermore, they highlight the need for studies to perform simultaneous measurements at both the molecular and whole animal levels.",
keywords = "seasonal adaptation, resting metabolic rate (RMR), daily energy expenditure (DEE), doubly-labelled water (DLW) technique, hypothalamic neuropeptides, Clethrionomys glareolus, bank vole, CORTICOTROPIN-RELEASING HORMONE, RESTING METABOLIC-RATE, FOOD-INTAKE, SIBERIAN HAMSTERS, NEUROPEPTIDE-Y, MICROTUS-PENNSYLVANICUS, COLLARED LEMMINGS, STRESS-RESPONSE, LEPTIN RECEPTOR, MESSENGER-RNA",
author = "Peacock, {W L} and E Krol and Moar, {K M} and McLaren, {J S} and Mercer, {J G} and Speakman, {J R}",
year = "2004",
doi = "10.1242/jeb.00719",
language = "English",
volume = "207",
pages = "165--177",
journal = "Journal of Experimental Biology",
issn = "0022-0949",
publisher = "Company of Biologists Ltd",

}

TY - JOUR

T1 - Photoperiodic effects on body mass, energy balance and hypothalamic gene expression in the bank vole

AU - Peacock, W L

AU - Krol, E

AU - Moar, K M

AU - McLaren, J S

AU - Mercer, J G

AU - Speakman, J R

PY - 2004

Y1 - 2004

N2 - We examined the effect of increasing photoperiod, at a constant low temperature, on the body mass and energy budget of the bank vole Clethrionomys glareolus. Simultaneously, we determined the hypothalamic gene expression of neuropeptides and receptors known to be involved in short-term energy balance. Despite an increase in body mass (approximately 10% of initial mass), we found no significant changes in any energetic parameters (food intake, energy assimilation rate, resting metabolic rate and total daily energy expenditure by doubly-labelled water). Apparent energy assimilation efficiency was higher in voles exposed to long-days (LD) compared to short-days (SD). Surprisingly, gene expression of corticotrophin releasing factor (CRF; in the paraventricular nucleus), and the melanocortin-3 receptor Summary (in the arcuate nucleus), both known to be involved in appetite suppression and elevation of energy expenditure in short-term energy balance, were higher in voles kept in LD compared to SD. CRF expression was also elevated in females compared to males. These paradoxical data suggest an alternative mechanism for the control of seasonal body mass changes compared to short-term body mass changes, and between male and female voles. Furthermore, they highlight the need for studies to perform simultaneous measurements at both the molecular and whole animal levels.

AB - We examined the effect of increasing photoperiod, at a constant low temperature, on the body mass and energy budget of the bank vole Clethrionomys glareolus. Simultaneously, we determined the hypothalamic gene expression of neuropeptides and receptors known to be involved in short-term energy balance. Despite an increase in body mass (approximately 10% of initial mass), we found no significant changes in any energetic parameters (food intake, energy assimilation rate, resting metabolic rate and total daily energy expenditure by doubly-labelled water). Apparent energy assimilation efficiency was higher in voles exposed to long-days (LD) compared to short-days (SD). Surprisingly, gene expression of corticotrophin releasing factor (CRF; in the paraventricular nucleus), and the melanocortin-3 receptor Summary (in the arcuate nucleus), both known to be involved in appetite suppression and elevation of energy expenditure in short-term energy balance, were higher in voles kept in LD compared to SD. CRF expression was also elevated in females compared to males. These paradoxical data suggest an alternative mechanism for the control of seasonal body mass changes compared to short-term body mass changes, and between male and female voles. Furthermore, they highlight the need for studies to perform simultaneous measurements at both the molecular and whole animal levels.

KW - seasonal adaptation

KW - resting metabolic rate (RMR)

KW - daily energy expenditure (DEE)

KW - doubly-labelled water (DLW) technique

KW - hypothalamic neuropeptides

KW - Clethrionomys glareolus

KW - bank vole

KW - CORTICOTROPIN-RELEASING HORMONE

KW - RESTING METABOLIC-RATE

KW - FOOD-INTAKE

KW - SIBERIAN HAMSTERS

KW - NEUROPEPTIDE-Y

KW - MICROTUS-PENNSYLVANICUS

KW - COLLARED LEMMINGS

KW - STRESS-RESPONSE

KW - LEPTIN RECEPTOR

KW - MESSENGER-RNA

U2 - 10.1242/jeb.00719

DO - 10.1242/jeb.00719

M3 - Article

VL - 207

SP - 165

EP - 177

JO - Journal of Experimental Biology

JF - Journal of Experimental Biology

SN - 0022-0949

ER -