Phylogenetic relationships within cation transporter families of Arabidopsis

P Maser, S Thomine, J I Schroeder, J M Ward, K Hirschi, H Sze, I N Talke, A Amtmann, F J M Maathuis, D Sanders, J F Harper, J Tchieu, M Gribskov, M W Persans, D E Salt, S A Kim, M L Guerinot

Research output: Contribution to journalLiterature review

771 Citations (Scopus)

Abstract

Uptake and translocation of cationic nutrients play essential roles in physiological processes including plant growth, nutrition, signal transduction, and development. Approximately 5% of the Arabidopsis genome appears to encode membrane transport proteins. These proteins are classified in 46 unique families containing approximately 880 members. In addition, several hundred putative transporters have not yet been assigned to families. In this paper, we have analyzed the phylogenetic relationships of over 150 cation transport proteins. This analysis has focused on cation transporter gene families for which initial characterizations have been achieved for individual members, including potassium transporters and channels, sodium transporters, calcium antiporters, cyclic nucleotide-gated channels, cation diffusion facilitator proteins, natural resistance-associated macrophage proteins (NRAMP), and Zn-regulated transporter Fe-regulated transporter-like proteins. Phylogenetic trees of each family define the evolutionary relationships of the members to each other. These families contain numerous members, indicating diverse functions in vivo. Closely related isoforms and separate subfamilies exist within many of these gene families, indicating possible redundancies and specialized functions. To facilitate their further study, the PlantsT database (http://plantst.sdsc.edu) has been created that includes alignments of the analyzed cation transporters and their chromosomal locations.

Original languageEnglish
Pages (from-to)1646-1667
Number of pages22
JournalPlant Physiology
Volume126
Issue number4
DOIs
Publication statusPublished - Aug 2001

Keywords

  • affinity potassium transporter
  • multiple sequence alignment
  • calmodulin-binding transporter
  • rectifying K+ channels
  • membrane H+-atpase
  • 2 pore domains
  • saccharomyces-cerevisiae
  • plasma-membrane
  • zinc-transporter
  • functional expression

Cite this

Maser, P., Thomine, S., Schroeder, J. I., Ward, J. M., Hirschi, K., Sze, H., Talke, I. N., Amtmann, A., Maathuis, F. J. M., Sanders, D., Harper, J. F., Tchieu, J., Gribskov, M., Persans, M. W., Salt, D. E., Kim, S. A., & Guerinot, M. L. (2001). Phylogenetic relationships within cation transporter families of Arabidopsis. Plant Physiology, 126(4), 1646-1667. https://doi.org/10.​1104/​pp.​126.​4.​1646