Phylogeny, culturing, and metagenomics of the human gut microbiota

Research output: Contribution to journalLiterature review

89 Citations (Scopus)

Abstract

The human intestinal tract is colonised by a complex community of microbes, which can have major impacts on host health. Recent research on the gut microbiota has largely been driven by the advent of modern sequence-based techniques, such as metagenomics. Although these are powerful and valuable tools, they have limitations. Traditional culturing and phylogeny can mitigate some of these limitations, either by expanding reference databases or by assigning functionality to specific microbial lineages. As such, culture and phylogeny will continue to have crucially important roles in human microbiota research, and will be required for the development of novel therapeutics.
Original languageEnglish
Pages (from-to)267-274
Number of pages8
JournalTrends in Microbiology
Volume22
Issue number5
Early online date31 Mar 2014
DOIs
Publication statusPublished - May 2014

Keywords

  • human gut microbiota
  • metagenomics
  • single-cell genomics
  • bacterial cultivation

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