Physicochemical degradation studies of calcium phosphate glass ceramic in the CaO-P2O5-MgO-TiO2 system

A. G. Dias, Iain Ronald Gibson, J. D. Santos, M. A. Lopes

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of this work was to evaluate the in vitro degradation behaviour of a 45CaO-37P(2)O(5)-5MgO-13TiO(2) (MOl.%) glass ceramic, under two different simulated physiological conditions: normal physiological pH 7.4, and pH 3.0, which was designed to simulate the acidic conditions produced by osteoclast cells. The in vitro testing was carried out at 37 degrees C for up to 42 days for the pH 7.4 solution and for up to 1 day for the pH 3.0 solution. The incorporation of TiO2 into the glass structure leads to the precipitation of specific crystalline phases in the glass matrix, namely alpha- and beta-Ca2P2O7, TiP2O7 and CaTi4(PO4)(6). The degradation testing at pH 3.0 showed a higher weight loss compared with degradation testing at pH 7.4; the weight loss under the acidic condition after I day (24 h) was about 10 times higher than the weight loss after 42 days of immersion at pH 7.4. The ionic release profile of Ca2+, PO43-, Mg2+ and Ti4+ showed a continuous increase in concentration over all immersion times for both testing solutions. After I day of immersion at pH 3.0, the concentration levels of Mg2+, Ca2+, PO43- were about six times higher than the levels achieved after 42 days of immersion at pH 7.4. The glass 4 ceramic showed similar degradation to hydroxyapatite, and therefore has potential to be used in certain clinical applications where relatively slow resorption of the implant and replacement by bone is required, e.g. cranioplasty.

Original languageEnglish
Pages (from-to)263-269
Number of pages7
JournalActa Biomaterialia
Volume3
Issue number2
Early online date5 Dec 2006
DOIs
Publication statusPublished - Mar 2007

Keywords

  • in vitro biodegradation
  • crystallization
  • biomaterials
  • bone
  • citric-acid
  • synthetic apatites
  • bone-resorption
  • ions
  • hydroxyapatite
  • biodegradation
  • metaphosphate
  • solubility
  • behavior
  • citrate

Cite this

Physicochemical degradation studies of calcium phosphate glass ceramic in the CaO-P2O5-MgO-TiO2 system. / Dias, A. G.; Gibson, Iain Ronald; Santos, J. D.; Lopes, M. A.

In: Acta Biomaterialia, Vol. 3, No. 2, 03.2007, p. 263-269.

Research output: Contribution to journalArticle

@article{150a71c31c6a428dae978340c668e501,
title = "Physicochemical degradation studies of calcium phosphate glass ceramic in the CaO-P2O5-MgO-TiO2 system",
abstract = "The aim of this work was to evaluate the in vitro degradation behaviour of a 45CaO-37P(2)O(5)-5MgO-13TiO(2) (MOl.{\%}) glass ceramic, under two different simulated physiological conditions: normal physiological pH 7.4, and pH 3.0, which was designed to simulate the acidic conditions produced by osteoclast cells. The in vitro testing was carried out at 37 degrees C for up to 42 days for the pH 7.4 solution and for up to 1 day for the pH 3.0 solution. The incorporation of TiO2 into the glass structure leads to the precipitation of specific crystalline phases in the glass matrix, namely alpha- and beta-Ca2P2O7, TiP2O7 and CaTi4(PO4)(6). The degradation testing at pH 3.0 showed a higher weight loss compared with degradation testing at pH 7.4; the weight loss under the acidic condition after I day (24 h) was about 10 times higher than the weight loss after 42 days of immersion at pH 7.4. The ionic release profile of Ca2+, PO43-, Mg2+ and Ti4+ showed a continuous increase in concentration over all immersion times for both testing solutions. After I day of immersion at pH 3.0, the concentration levels of Mg2+, Ca2+, PO43- were about six times higher than the levels achieved after 42 days of immersion at pH 7.4. The glass 4 ceramic showed similar degradation to hydroxyapatite, and therefore has potential to be used in certain clinical applications where relatively slow resorption of the implant and replacement by bone is required, e.g. cranioplasty.",
keywords = "in vitro biodegradation, crystallization, biomaterials, bone, citric-acid, synthetic apatites, bone-resorption, ions, hydroxyapatite, biodegradation, metaphosphate, solubility, behavior, citrate",
author = "Dias, {A. G.} and Gibson, {Iain Ronald} and Santos, {J. D.} and Lopes, {M. A.}",
year = "2007",
month = "3",
doi = "10.1016/j.actbio.2006.09.009",
language = "English",
volume = "3",
pages = "263--269",
journal = "Acta Biomaterialia",
issn = "1742-7061",
publisher = "Elsevier BV",
number = "2",

}

TY - JOUR

T1 - Physicochemical degradation studies of calcium phosphate glass ceramic in the CaO-P2O5-MgO-TiO2 system

AU - Dias, A. G.

AU - Gibson, Iain Ronald

AU - Santos, J. D.

AU - Lopes, M. A.

PY - 2007/3

Y1 - 2007/3

N2 - The aim of this work was to evaluate the in vitro degradation behaviour of a 45CaO-37P(2)O(5)-5MgO-13TiO(2) (MOl.%) glass ceramic, under two different simulated physiological conditions: normal physiological pH 7.4, and pH 3.0, which was designed to simulate the acidic conditions produced by osteoclast cells. The in vitro testing was carried out at 37 degrees C for up to 42 days for the pH 7.4 solution and for up to 1 day for the pH 3.0 solution. The incorporation of TiO2 into the glass structure leads to the precipitation of specific crystalline phases in the glass matrix, namely alpha- and beta-Ca2P2O7, TiP2O7 and CaTi4(PO4)(6). The degradation testing at pH 3.0 showed a higher weight loss compared with degradation testing at pH 7.4; the weight loss under the acidic condition after I day (24 h) was about 10 times higher than the weight loss after 42 days of immersion at pH 7.4. The ionic release profile of Ca2+, PO43-, Mg2+ and Ti4+ showed a continuous increase in concentration over all immersion times for both testing solutions. After I day of immersion at pH 3.0, the concentration levels of Mg2+, Ca2+, PO43- were about six times higher than the levels achieved after 42 days of immersion at pH 7.4. The glass 4 ceramic showed similar degradation to hydroxyapatite, and therefore has potential to be used in certain clinical applications where relatively slow resorption of the implant and replacement by bone is required, e.g. cranioplasty.

AB - The aim of this work was to evaluate the in vitro degradation behaviour of a 45CaO-37P(2)O(5)-5MgO-13TiO(2) (MOl.%) glass ceramic, under two different simulated physiological conditions: normal physiological pH 7.4, and pH 3.0, which was designed to simulate the acidic conditions produced by osteoclast cells. The in vitro testing was carried out at 37 degrees C for up to 42 days for the pH 7.4 solution and for up to 1 day for the pH 3.0 solution. The incorporation of TiO2 into the glass structure leads to the precipitation of specific crystalline phases in the glass matrix, namely alpha- and beta-Ca2P2O7, TiP2O7 and CaTi4(PO4)(6). The degradation testing at pH 3.0 showed a higher weight loss compared with degradation testing at pH 7.4; the weight loss under the acidic condition after I day (24 h) was about 10 times higher than the weight loss after 42 days of immersion at pH 7.4. The ionic release profile of Ca2+, PO43-, Mg2+ and Ti4+ showed a continuous increase in concentration over all immersion times for both testing solutions. After I day of immersion at pH 3.0, the concentration levels of Mg2+, Ca2+, PO43- were about six times higher than the levels achieved after 42 days of immersion at pH 7.4. The glass 4 ceramic showed similar degradation to hydroxyapatite, and therefore has potential to be used in certain clinical applications where relatively slow resorption of the implant and replacement by bone is required, e.g. cranioplasty.

KW - in vitro biodegradation

KW - crystallization

KW - biomaterials

KW - bone

KW - citric-acid

KW - synthetic apatites

KW - bone-resorption

KW - ions

KW - hydroxyapatite

KW - biodegradation

KW - metaphosphate

KW - solubility

KW - behavior

KW - citrate

U2 - 10.1016/j.actbio.2006.09.009

DO - 10.1016/j.actbio.2006.09.009

M3 - Article

VL - 3

SP - 263

EP - 269

JO - Acta Biomaterialia

JF - Acta Biomaterialia

SN - 1742-7061

IS - 2

ER -