Physiological and pathophysiological implications of lipid sensing in the brain

A Picard, V S Moullé, C Le Foll, C Cansell, J Véret, N Coant, H Le Stunff, S Migrenne, S Luquet, C Cruciani-Guglielmacci, B E Levin, C Magnan

Research output: Contribution to journalLiterature review

17 Citations (Scopus)

Abstract

Fatty acid (FA)-sensitive neurons are present in the brain, especially the hypothalamus, and play a key role in the neural control of energy homeostasis. Through neuronal output, FA may modulate feeding behaviour as well as insulin secretion and action. Subpopulations of neurons in the ventromedial and arcuate hypothalamic nuclei are selectively either inhibited or activated by FA. Molecular effectors of these FA effects probably include chloride or potassium ion channels. While intracellular metabolism and activation of the ATP-sensitive K(+) channel appear to be necessary for some of the signalling effects of FA, at least half of the FA responses in ventromedial hypothalamic neurons are mediated by interaction with FAT/CD36, an FA transporter/receptor that does not require intracellular metabolism to activate downstream signalling. Thus, FA or their metabolites can modulate neuronal activity as a means of directly monitoring ongoing fuel availability by brain nutrient-sensing neurons involved in the regulation of energy and glucose homeostasis. Recently, the role of lipoprotein lipase in FA sensing has also been shown in animal models not only in hypothalamus, but also in hippocampus and striatum. Finally, FA overload might impair neural control of energy homeostasis through enhanced ceramide synthesis and may contribute to obesity and/or type 2 diabetes pathogenesis in predisposed subjects.

Original languageEnglish
Pages (from-to)49-55
Number of pages7
JournalDiabetes, Obesity & Metabolism
Volume16
Issue numberSuppl 1
DOIs
Publication statusPublished - Sep 2014

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Fatty Acids
Lipids
Brain
Neurons
Homeostasis
Hypothalamus
Ventromedial Hypothalamic Nucleus
CD36 Antigens
Arcuate Nucleus of Hypothalamus
Chloride Channels
Lipoprotein Lipase
Ceramides
Potassium Channels
Feeding Behavior
Type 2 Diabetes Mellitus
Hippocampus
Animal Models
Obesity
Adenosine Triphosphate
Insulin

Keywords

  • energy balance
  • FAT/CD36
  • hypothalamus
  • potassium channel

Cite this

Picard, A., Moullé, V. S., Le Foll, C., Cansell, C., Véret, J., Coant, N., ... Magnan, C. (2014). Physiological and pathophysiological implications of lipid sensing in the brain. Diabetes, Obesity & Metabolism, 16 (Suppl 1), 49-55. https://doi.org/10.1111/dom.12335

Physiological and pathophysiological implications of lipid sensing in the brain. / Picard, A; Moullé, V S; Le Foll, C; Cansell, C; Véret, J; Coant, N; Le Stunff, H; Migrenne, S; Luquet, S; Cruciani-Guglielmacci, C; Levin, B E; Magnan, C.

In: Diabetes, Obesity & Metabolism, Vol. 16 , No. Suppl 1, 09.2014, p. 49-55.

Research output: Contribution to journalLiterature review

Picard, A, Moullé, VS, Le Foll, C, Cansell, C, Véret, J, Coant, N, Le Stunff, H, Migrenne, S, Luquet, S, Cruciani-Guglielmacci, C, Levin, BE & Magnan, C 2014, 'Physiological and pathophysiological implications of lipid sensing in the brain', Diabetes, Obesity & Metabolism, vol. 16 , no. Suppl 1, pp. 49-55. https://doi.org/10.1111/dom.12335
Picard A, Moullé VS, Le Foll C, Cansell C, Véret J, Coant N et al. Physiological and pathophysiological implications of lipid sensing in the brain. Diabetes, Obesity & Metabolism. 2014 Sep;16 (Suppl 1):49-55. https://doi.org/10.1111/dom.12335
Picard, A ; Moullé, V S ; Le Foll, C ; Cansell, C ; Véret, J ; Coant, N ; Le Stunff, H ; Migrenne, S ; Luquet, S ; Cruciani-Guglielmacci, C ; Levin, B E ; Magnan, C. / Physiological and pathophysiological implications of lipid sensing in the brain. In: Diabetes, Obesity & Metabolism. 2014 ; Vol. 16 , No. Suppl 1. pp. 49-55.
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