Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum

Daniela Rigano, Armando Grassia, Francesca Borrelli, Gabriella Aviello, Franco Piozzi, Maurizio Bruno, Nelly Apostolides Arnold, Raffaele Capasso, Felice Senatore

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A new natural labdane diterpene, marrulibanoside, was isolated from the acetonic extract of aerial parts of M. globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae). Its structure was determined by spectroscopic methods such as 1D and 2D NMR and mass spectrometry. Pharmacological studies have shown that the extract of M. globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition.

Original languageEnglish
Pages (from-to)575-578
Number of pages4
JournalPlanta Medica
Volume72
Issue number6
DOIs
Publication statusPublished - May 2006

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Marrubium
Lamiaceae
Diterpenes
Carrageenan
Phytochemicals
Mass spectrometry
Swelling
Rats
Edema
Mass Spectrometry
Anti-Inflammatory Agents
Nuclear magnetic resonance
Pharmacology
Antennas

Keywords

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Blotting, Western
  • Carrageenan
  • Dinoprostone
  • Edema
  • Macrophages, Peritoneal
  • Male
  • Marrubium
  • Mice
  • Nitric Oxide Synthase Type II
  • Phytotherapy
  • Plant Components, Aerial
  • Plant Extracts
  • Rats
  • Rats, Wistar
  • Journal Article
  • Research Support, Non-U.S. Gov't

Cite this

Rigano, D., Grassia, A., Borrelli, F., Aviello, G., Piozzi, F., Bruno, M., ... Senatore, F. (2006). Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum. Planta Medica, 72(6), 575-578. https://doi.org/10.1055/s-2006-931557

Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum. / Rigano, Daniela; Grassia, Armando; Borrelli, Francesca; Aviello, Gabriella; Piozzi, Franco; Bruno, Maurizio; Arnold, Nelly Apostolides; Capasso, Raffaele; Senatore, Felice.

In: Planta Medica, Vol. 72, No. 6, 05.2006, p. 575-578.

Research output: Contribution to journalArticle

Rigano, D, Grassia, A, Borrelli, F, Aviello, G, Piozzi, F, Bruno, M, Arnold, NA, Capasso, R & Senatore, F 2006, 'Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum' Planta Medica, vol. 72, no. 6, pp. 575-578. https://doi.org/10.1055/s-2006-931557
Rigano, Daniela ; Grassia, Armando ; Borrelli, Francesca ; Aviello, Gabriella ; Piozzi, Franco ; Bruno, Maurizio ; Arnold, Nelly Apostolides ; Capasso, Raffaele ; Senatore, Felice. / Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum. In: Planta Medica. 2006 ; Vol. 72, No. 6. pp. 575-578.
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