Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum

Daniela Rigano; Armando Grassia; Francesca Borrelli; Gabriella Aviello; Franco Piozzi; Maurizio Bruno; Nelly Apostolides Arnold; Raffaele Capasso; Felice Senatore

doi:10.1055/s-2006-931557

Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum

Daniela Rigano, Armando Grassia, Francesca Borrelli, Gabriella Aviello, Franco Piozzi, Maurizio Bruno, Nelly Apostolides Arnold, Raffaele Capasso, Felice Senatore

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

A new natural labdane diterpene, marrulibanoside, was isolated from the acetonic extract of aerial parts of M. globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae). Its structure was determined by spectroscopic methods such as 1D and 2D NMR and mass spectrometry. Pharmacological studies have shown that the extract of M. globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition.

Original language	English
Pages (from-to)	575-578
Number of pages	4
Journal	Planta Medica
Volume	72
Issue number	6
DOIs	https://doi.org/10.1055/s-2006-931557
Publication status	Published - May 2006

Keywords

Animals
Anti-Inflammatory Agents, Non-Steroidal
Blotting, Western
Carrageenan
Dinoprostone
Edema
Macrophages, Peritoneal
Male
Marrubium
Mice
Nitric Oxide Synthase Type II
Phytotherapy
Plant Components, Aerial
Plant Extracts
Rats
Rats, Wistar
Journal Article
Research Support, Non-U.S. Gov't

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title = "Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum",

abstract = "A new natural labdane diterpene, marrulibanoside, was isolated from the acetonic extract of aerial parts of M. globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae). Its structure was determined by spectroscopic methods such as 1D and 2D NMR and mass spectrometry. Pharmacological studies have shown that the extract of M. globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition.",

keywords = "Animals, Anti-Inflammatory Agents, Non-Steroidal, Blotting, Western, Carrageenan, Dinoprostone, Edema, Macrophages, Peritoneal, Male, Marrubium, Mice, Nitric Oxide Synthase Type II, Phytotherapy, Plant Components, Aerial, Plant Extracts, Rats, Rats, Wistar, Journal Article, Research Support, Non-U.S. Gov't",

author = "Daniela Rigano and Armando Grassia and Francesca Borrelli and Gabriella Aviello and Franco Piozzi and Maurizio Bruno and Arnold, {Nelly Apostolides} and Raffaele Capasso and Felice Senatore",

year = "2006",

month = may,

doi = "10.1055/s-2006-931557",

language = "English",

volume = "72",

pages = "575--578",

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T1 - Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum

AU - Rigano, Daniela

AU - Grassia, Armando

AU - Borrelli, Francesca

AU - Aviello, Gabriella

AU - Piozzi, Franco

AU - Bruno, Maurizio

AU - Arnold, Nelly Apostolides

AU - Capasso, Raffaele

AU - Senatore, Felice

PY - 2006/5

Y1 - 2006/5

N2 - A new natural labdane diterpene, marrulibanoside, was isolated from the acetonic extract of aerial parts of M. globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae). Its structure was determined by spectroscopic methods such as 1D and 2D NMR and mass spectrometry. Pharmacological studies have shown that the extract of M. globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition.

AB - A new natural labdane diterpene, marrulibanoside, was isolated from the acetonic extract of aerial parts of M. globosum Montbr. et Auch. ex Benth. ssp. libanoticum Boiss. (Lamiaceae). Its structure was determined by spectroscopic methods such as 1D and 2D NMR and mass spectrometry. Pharmacological studies have shown that the extract of M. globosum exerts anti-inflammatory effects in the rat paw oedema induced by carrageenin resulting in reduced paw swelling. This activity, which seems due to marrulibanoside, is a consequence of iNOS and COX-2 activities inhibition.

KW - Animals

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Blotting, Western

KW - Carrageenan

KW - Dinoprostone

KW - Edema

KW - Macrophages, Peritoneal

KW - Male

KW - Marrubium

KW - Mice

KW - Nitric Oxide Synthase Type II

KW - Phytotherapy

KW - Plant Components, Aerial

KW - Plant Extracts

KW - Rats

KW - Rats, Wistar

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1055/s-2006-931557

DO - 10.1055/s-2006-931557

M3 - Article

C2 - 16773546

VL - 72

SP - 575

EP - 578

JO - Planta Medica

JF - Planta Medica

SN - 0032-0943

IS - 6

ER -

Phytochemical and pharmacological studies on the acetonic extract of Marrubium globosum ssp. libanoticum

Abstract

Keywords

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