Placental leptin

Cheryl Ashworth, Nigel Hoggard, Louise Thomas, Julian Mercer, Jacqueline Wallace, R.g. Lea

Research output: Contribution to journalArticle

154 Citations (Scopus)

Abstract

Placental tissues from humans, rodents and farm animals contain leptin and its receptor. Leptin produced by the human placenta has the same size, charge and immunoreactivity as leptin produced by adipose tissue. However, the expression of human placental leptin appears to be regulated by a placenta-specific upstream enhancer. In this review the occurrence of leptin and its receptor in a range of species and placental types is described, and its significance during pregnancy discussed. Placental leptin contributes to the increase in maternal circulating concentrations of leptin during late pregnancy when it is likely to have an endocrine role in regulating maternal energy balance. Placental leptin may have angiogenic and immunomodulatory activities, which affect the placenta in an autocrine or paracrine manner. It also appears to affect fetal growth and development by binding to leptin receptors present in fetal organs.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalReviews of Reproduction
Volume5
Issue number1
DOIs
Publication statusPublished - Jan 2000

Keywords

  • receptor messenger-RNA
  • serum leptin
  • pregnancy
  • increase
  • tissue

Cite this

Placental leptin. / Ashworth, Cheryl; Hoggard, Nigel; Thomas, Louise; Mercer, Julian; Wallace, Jacqueline; Lea, R.g.

In: Reviews of Reproduction, Vol. 5, No. 1, 01.2000, p. 18-24.

Research output: Contribution to journalArticle

Ashworth, Cheryl ; Hoggard, Nigel ; Thomas, Louise ; Mercer, Julian ; Wallace, Jacqueline ; Lea, R.g. / Placental leptin. In: Reviews of Reproduction. 2000 ; Vol. 5, No. 1. pp. 18-24.
@article{7feee39121ed40e09cd4f34a8d06c23a,
title = "Placental leptin",
abstract = "Placental tissues from humans, rodents and farm animals contain leptin and its receptor. Leptin produced by the human placenta has the same size, charge and immunoreactivity as leptin produced by adipose tissue. However, the expression of human placental leptin appears to be regulated by a placenta-specific upstream enhancer. In this review the occurrence of leptin and its receptor in a range of species and placental types is described, and its significance during pregnancy discussed. Placental leptin contributes to the increase in maternal circulating concentrations of leptin during late pregnancy when it is likely to have an endocrine role in regulating maternal energy balance. Placental leptin may have angiogenic and immunomodulatory activities, which affect the placenta in an autocrine or paracrine manner. It also appears to affect fetal growth and development by binding to leptin receptors present in fetal organs.",
keywords = "receptor messenger-RNA, serum leptin, pregnancy, increase, tissue",
author = "Cheryl Ashworth and Nigel Hoggard and Louise Thomas and Julian Mercer and Jacqueline Wallace and R.g. Lea",
year = "2000",
month = "1",
doi = "10.1530/ror.0.0050018",
language = "English",
volume = "5",
pages = "18--24",
journal = "Reviews of Reproduction",
issn = "1359-6004",
publisher = "Society for Reproduction and Fertility",
number = "1",

}

TY - JOUR

T1 - Placental leptin

AU - Ashworth, Cheryl

AU - Hoggard, Nigel

AU - Thomas, Louise

AU - Mercer, Julian

AU - Wallace, Jacqueline

AU - Lea, R.g.

PY - 2000/1

Y1 - 2000/1

N2 - Placental tissues from humans, rodents and farm animals contain leptin and its receptor. Leptin produced by the human placenta has the same size, charge and immunoreactivity as leptin produced by adipose tissue. However, the expression of human placental leptin appears to be regulated by a placenta-specific upstream enhancer. In this review the occurrence of leptin and its receptor in a range of species and placental types is described, and its significance during pregnancy discussed. Placental leptin contributes to the increase in maternal circulating concentrations of leptin during late pregnancy when it is likely to have an endocrine role in regulating maternal energy balance. Placental leptin may have angiogenic and immunomodulatory activities, which affect the placenta in an autocrine or paracrine manner. It also appears to affect fetal growth and development by binding to leptin receptors present in fetal organs.

AB - Placental tissues from humans, rodents and farm animals contain leptin and its receptor. Leptin produced by the human placenta has the same size, charge and immunoreactivity as leptin produced by adipose tissue. However, the expression of human placental leptin appears to be regulated by a placenta-specific upstream enhancer. In this review the occurrence of leptin and its receptor in a range of species and placental types is described, and its significance during pregnancy discussed. Placental leptin contributes to the increase in maternal circulating concentrations of leptin during late pregnancy when it is likely to have an endocrine role in regulating maternal energy balance. Placental leptin may have angiogenic and immunomodulatory activities, which affect the placenta in an autocrine or paracrine manner. It also appears to affect fetal growth and development by binding to leptin receptors present in fetal organs.

KW - receptor messenger-RNA

KW - serum leptin

KW - pregnancy

KW - increase

KW - tissue

U2 - 10.1530/ror.0.0050018

DO - 10.1530/ror.0.0050018

M3 - Article

VL - 5

SP - 18

EP - 24

JO - Reviews of Reproduction

JF - Reviews of Reproduction

SN - 1359-6004

IS - 1

ER -