Plant-derived phenolic antioxidants

Garry G. Duthie, Alan Crozier

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Antioxidant nutrients are important for limiting damaging oxidative reactions in cells, which may predispose to the development of major clinical conditions such as heart disease and cancer. There is great interest in the possibility that the antioxidant potential of plant-derived phenolic compounds, such as flavonoids, may reduce the risk of developing these conditions. Antioxidant effectiveness in vivo depends on the bioavailability of these compounds, which was assumed to be low. However, recent studies with improved methodology indicate that some plant phenolics appear in plasma and body tissues and, thus, may be important nutritional antioxidants. However, this cannot be established with certainty until their effects on biomarkers of oxidative stress are established.
Original languageEnglish
Pages (from-to)447-451
Number of pages5
JournalCurrent Opinion in Clinical Nutrition and Metabolic Care
Volume3
Issue number6
Publication statusPublished - Nov 2000

Fingerprint

Antioxidants
Heart Neoplasms
Phytochemicals
Flavonoids
Biological Availability
Heart Diseases
Oxidative Stress
Biomarkers
Food

Keywords

  • animals
  • neoplasms
  • flavonoids
  • plants, edible
  • heart diseases
  • antioxidants
  • humans
  • oxidative stress
  • diet
  • phenols
  • biological markers
  • biological availability

Cite this

Plant-derived phenolic antioxidants. / Duthie, Garry G.; Crozier, Alan.

In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 3, No. 6, 11.2000, p. 447-451.

Research output: Contribution to journalArticle

@article{42b7cbe0243b4d608391412d23076abc,
title = "Plant-derived phenolic antioxidants",
abstract = "Antioxidant nutrients are important for limiting damaging oxidative reactions in cells, which may predispose to the development of major clinical conditions such as heart disease and cancer. There is great interest in the possibility that the antioxidant potential of plant-derived phenolic compounds, such as flavonoids, may reduce the risk of developing these conditions. Antioxidant effectiveness in vivo depends on the bioavailability of these compounds, which was assumed to be low. However, recent studies with improved methodology indicate that some plant phenolics appear in plasma and body tissues and, thus, may be important nutritional antioxidants. However, this cannot be established with certainty until their effects on biomarkers of oxidative stress are established.",
keywords = "animals, neoplasms, flavonoids, plants, edible, heart diseases, antioxidants, humans, oxidative stress, diet, phenols, biological markers, biological availability",
author = "Duthie, {Garry G.} and Alan Crozier",
year = "2000",
month = "11",
language = "English",
volume = "3",
pages = "447--451",
journal = "Current Opinion in Clinical Nutrition and Metabolic Care",
issn = "1363-1950",
publisher = "Lippincott Williams and Wilkins",
number = "6",

}

TY - JOUR

T1 - Plant-derived phenolic antioxidants

AU - Duthie, Garry G.

AU - Crozier, Alan

PY - 2000/11

Y1 - 2000/11

N2 - Antioxidant nutrients are important for limiting damaging oxidative reactions in cells, which may predispose to the development of major clinical conditions such as heart disease and cancer. There is great interest in the possibility that the antioxidant potential of plant-derived phenolic compounds, such as flavonoids, may reduce the risk of developing these conditions. Antioxidant effectiveness in vivo depends on the bioavailability of these compounds, which was assumed to be low. However, recent studies with improved methodology indicate that some plant phenolics appear in plasma and body tissues and, thus, may be important nutritional antioxidants. However, this cannot be established with certainty until their effects on biomarkers of oxidative stress are established.

AB - Antioxidant nutrients are important for limiting damaging oxidative reactions in cells, which may predispose to the development of major clinical conditions such as heart disease and cancer. There is great interest in the possibility that the antioxidant potential of plant-derived phenolic compounds, such as flavonoids, may reduce the risk of developing these conditions. Antioxidant effectiveness in vivo depends on the bioavailability of these compounds, which was assumed to be low. However, recent studies with improved methodology indicate that some plant phenolics appear in plasma and body tissues and, thus, may be important nutritional antioxidants. However, this cannot be established with certainty until their effects on biomarkers of oxidative stress are established.

KW - animals

KW - neoplasms

KW - flavonoids

KW - plants, edible

KW - heart diseases

KW - antioxidants

KW - humans

KW - oxidative stress

KW - diet

KW - phenols

KW - biological markers

KW - biological availability

M3 - Article

VL - 3

SP - 447

EP - 451

JO - Current Opinion in Clinical Nutrition and Metabolic Care

JF - Current Opinion in Clinical Nutrition and Metabolic Care

SN - 1363-1950

IS - 6

ER -