Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis

Jeremy M Sternberg, Julia A Mitchell

Research output: Contribution to journalArticle

2 Citations (Scopus)
5 Downloads (Pure)

Abstract

BACKGROUND: This study was carried out to determine the potential of neuronal specific enolase (NSE) as a stage diagnostic marker in human African trypanosomiasis.

METHODS: Plasma and cerebrospinal fluid were obtained from a cohort of Trypanosoma brucei rhodesiense-infected patients and non-infected controls. Neuronal specific enolase concentrations were measured by ELISA and analysed in relation to diagnosis and disease-stage data.

RESULTS: Plasma NSE concentration was significantly increased in late-stage patients (median 21 ng/ml), compared to the control (median 11 ng/ml), but not in early-stage patients (median 5.3 ng/ml). Cerebrospinal fluid NSE concentration did not vary between stages.

CONCLUSION: Plasma NSE is a potential stage diagnostic in this cohort and merits further investigation.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume108
Issue number7
Early online date30 Apr 2014
DOIs
Publication statusPublished - Jul 2014

Keywords

  • African trypanosomiasis
  • neuronal specific enolase
  • stage

Fingerprint Dive into the research topics of 'Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis'. Together they form a unique fingerprint.

  • Cite this