Plasma neuronal specific enolase

a potential stage diagnostic marker in human African trypanosomiasis

Jeremy M Sternberg, Julia A Mitchell

Research output: Contribution to journalArticle

1 Citation (Scopus)
3 Downloads (Pure)

Abstract

BACKGROUND: This study was carried out to determine the potential of neuronal specific enolase (NSE) as a stage diagnostic marker in human African trypanosomiasis.

METHODS: Plasma and cerebrospinal fluid were obtained from a cohort of Trypanosoma brucei rhodesiense-infected patients and non-infected controls. Neuronal specific enolase concentrations were measured by ELISA and analysed in relation to diagnosis and disease-stage data.

RESULTS: Plasma NSE concentration was significantly increased in late-stage patients (median 21 ng/ml), compared to the control (median 11 ng/ml), but not in early-stage patients (median 5.3 ng/ml). Cerebrospinal fluid NSE concentration did not vary between stages.

CONCLUSION: Plasma NSE is a potential stage diagnostic in this cohort and merits further investigation.

Original languageEnglish
Pages (from-to)449-452
Number of pages4
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume108
Issue number7
Early online date30 Apr 2014
DOIs
Publication statusPublished - Jul 2014

Fingerprint

African Trypanosomiasis
Phosphopyruvate Hydratase
Cerebrospinal Fluid
Trypanosoma brucei rhodesiense
Enzyme-Linked Immunosorbent Assay

Keywords

  • African trypanosomiasis
  • neuronal specific enolase
  • stage

Cite this

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title = "Plasma neuronal specific enolase: a potential stage diagnostic marker in human African trypanosomiasis",
abstract = "BACKGROUND: This study was carried out to determine the potential of neuronal specific enolase (NSE) as a stage diagnostic marker in human African trypanosomiasis.METHODS: Plasma and cerebrospinal fluid were obtained from a cohort of Trypanosoma brucei rhodesiense-infected patients and non-infected controls. Neuronal specific enolase concentrations were measured by ELISA and analysed in relation to diagnosis and disease-stage data.RESULTS: Plasma NSE concentration was significantly increased in late-stage patients (median 21 ng/ml), compared to the control (median 11 ng/ml), but not in early-stage patients (median 5.3 ng/ml). Cerebrospinal fluid NSE concentration did not vary between stages.CONCLUSION: Plasma NSE is a potential stage diagnostic in this cohort and merits further investigation.",
keywords = "African trypanosomiasis, neuronal specific enolase, stage",
author = "Sternberg, {Jeremy M} and Mitchell, {Julia A}",
note = "{\circledC} The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Funding: This work was supported through grants from the Wellcome Trust [082786] and Foundation for Innovative New Diagnostics.",
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T1 - Plasma neuronal specific enolase

T2 - a potential stage diagnostic marker in human African trypanosomiasis

AU - Sternberg, Jeremy M

AU - Mitchell, Julia A

N1 - © The Author 2014. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. Funding: This work was supported through grants from the Wellcome Trust [082786] and Foundation for Innovative New Diagnostics.

PY - 2014/7

Y1 - 2014/7

N2 - BACKGROUND: This study was carried out to determine the potential of neuronal specific enolase (NSE) as a stage diagnostic marker in human African trypanosomiasis.METHODS: Plasma and cerebrospinal fluid were obtained from a cohort of Trypanosoma brucei rhodesiense-infected patients and non-infected controls. Neuronal specific enolase concentrations were measured by ELISA and analysed in relation to diagnosis and disease-stage data.RESULTS: Plasma NSE concentration was significantly increased in late-stage patients (median 21 ng/ml), compared to the control (median 11 ng/ml), but not in early-stage patients (median 5.3 ng/ml). Cerebrospinal fluid NSE concentration did not vary between stages.CONCLUSION: Plasma NSE is a potential stage diagnostic in this cohort and merits further investigation.

AB - BACKGROUND: This study was carried out to determine the potential of neuronal specific enolase (NSE) as a stage diagnostic marker in human African trypanosomiasis.METHODS: Plasma and cerebrospinal fluid were obtained from a cohort of Trypanosoma brucei rhodesiense-infected patients and non-infected controls. Neuronal specific enolase concentrations were measured by ELISA and analysed in relation to diagnosis and disease-stage data.RESULTS: Plasma NSE concentration was significantly increased in late-stage patients (median 21 ng/ml), compared to the control (median 11 ng/ml), but not in early-stage patients (median 5.3 ng/ml). Cerebrospinal fluid NSE concentration did not vary between stages.CONCLUSION: Plasma NSE is a potential stage diagnostic in this cohort and merits further investigation.

KW - African trypanosomiasis

KW - neuronal specific enolase

KW - stage

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JO - Transactions of the Royal Society of Tropical Medicine and Hygiene

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