Plasmin-antiplasmin system

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

Plasmin is the key enzyme involved in the dissolution of fibrin. It is produced from plasminogen, which is activated by a plasminogen activator; the two primary activators are tissue-type plasminogen activator (tPA) and urinary-type plasminogen activator (uPA), also called urokinase. The process is regulated by inhibitors, principally plasminogen activator inhibitor 1 (PAI-1), α2-antiplasmin (α2AP) and thrombin-activatable fibrinolysis inhibitor (TAFI). Crucial control is exerted by surfaces, such as fibrin or cells, with plasminogen activation not normally occurring in the circulation. Here we will consider the individual players of the fibrinolytic cascade and their specific locations and potential interactions. Key questions considered are the initiation of fibrinolysis and the most appropriate ways to measure abnormalities in disease situations.

Original languageEnglish
Title of host publicationTrauma Induced Coagulopathy
EditorsEduardo Gonzalez, Hunter B Moore, Ernest E Moore
PublisherSpringer International Publishing
Pages31-51
Number of pages21
ISBN (Print)9783319283081, 9783319283067
DOIs
Publication statusPublished - 19 Apr 2016

Fingerprint

Antifibrinolytic Agents
Plasminogen
Fibrinolysin
Urokinase-Type Plasminogen Activator
Fibrin
Carboxypeptidase B2
Plasminogen Activator Inhibitor 2
Plasminogen Activators
Plasminogen Activator Inhibitor 1
Fibrinolysis
Tissue Plasminogen Activator
Enzymes

Keywords

  • Contact pathway
  • Factor XIII
  • Fibrinogen/fibrin
  • Fibrinolysis
  • Plasminogen activator inhibitor 1 (PAI-1)
  • Plasminogen/plasmin
  • Thrombin-activatable fibrinolysis inhibitor (TAFI CPB2)
  • Tissue plasminogen activator (tPA)
  • Urokinase (uPA)
  • αantiplasmin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mutch, N. J., & Booth, N. A. (2016). Plasmin-antiplasmin system. In E. Gonzalez, H. B. Moore, & E. E. Moore (Eds.), Trauma Induced Coagulopathy (pp. 31-51). Springer International Publishing. https://doi.org/10.1007/978-3-319-28308-1_3

Plasmin-antiplasmin system. / Mutch, Nicola J.; Booth, Nuala A.

Trauma Induced Coagulopathy. ed. / Eduardo Gonzalez; Hunter B Moore; Ernest E Moore. Springer International Publishing, 2016. p. 31-51.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mutch, NJ & Booth, NA 2016, Plasmin-antiplasmin system. in E Gonzalez, HB Moore & EE Moore (eds), Trauma Induced Coagulopathy. Springer International Publishing, pp. 31-51. https://doi.org/10.1007/978-3-319-28308-1_3
Mutch NJ, Booth NA. Plasmin-antiplasmin system. In Gonzalez E, Moore HB, Moore EE, editors, Trauma Induced Coagulopathy. Springer International Publishing. 2016. p. 31-51 https://doi.org/10.1007/978-3-319-28308-1_3
Mutch, Nicola J. ; Booth, Nuala A. / Plasmin-antiplasmin system. Trauma Induced Coagulopathy. editor / Eduardo Gonzalez ; Hunter B Moore ; Ernest E Moore. Springer International Publishing, 2016. pp. 31-51
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