Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

Xuguang Zhang; Susan C McGeoch; Alexandra M Johnstone; Grietje Holtrop; Alan A Sneddon; Sandra M Macrury; Ian L Megson; Donald W M Pearson; Prakash Abraham; Baukje De Roos; Gerald E Lobley; Niamh O'Kennedy

doi:10.1007/s11239-013-1000-2

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

Xuguang Zhang, Susan C McGeoch, Alexandra M Johnstone, Grietje Holtrop, Alan A Sneddon, Sandra M Macrury, Ian L Megson, Donald W M Pearson, Prakash Abraham, Baukje De Roos, Gerald E Lobley, Niamh O'Kennedy

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (P = 0.003), and PMP that were fibrinogen-positive (P = 0.04), tissue factor-positive (P < 0.001), P-selectin-positive (P = 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.

Original language	English
Pages (from-to)	455-463
Number of pages	9
Journal	Journal of Thrombosis and Thrombolysis
Volume	37
Issue number	4
Early online date	5 Oct 2013
DOIs	https://doi.org/10.1007/s11239-013-1000-2
Publication status	Published - May 2014

Bibliographical note

Acknowledgments:
This study was partly funded by a Grant awarded by the Chief Scientists Office of the Scottish Government to the University of the Highlands and Islands, Rowett Institute of Nutrition & Health at the University of Aberdeen and Aberdeen
Royal Infirmary to examine the impact of diets rich in oats for life-style control of type 2 diabetes. Additional support was contributed by the Rural & Environment Science & Analytical Services (RESAS) of the Scottish Government to Rowett Institute of Nutrition & Health (RINH). Costs of microparticle anayses were borne by Provexis Plc.

Keywords

circulating cell-derived microparticles
obesity
Type 2 diabetes mellitus
blood platelets
cardiovascular diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11239-013-1000-2

Alan Sneddon
- School of Medicine, Medical Sciences & Nutrition, The Rowett Institute of Nutrition and Health - Research Fellow
Person: Academic Related - Research

Cite this

Zhang, X., McGeoch, S. C., Johnstone, A. M., Holtrop, G., Sneddon, A. A., Macrury, S. M., Megson, I. L., Pearson, D. W. M., Abraham, P., De Roos, B., Lobley, G. E., & O'Kennedy, N. (2014). Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status. Journal of Thrombosis and Thrombolysis, 37(4), 455-463. https://doi.org/10.1007/s11239-013-1000-2

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status. / Zhang, Xuguang; McGeoch, Susan C; Johnstone, Alexandra M et al.
In: Journal of Thrombosis and Thrombolysis, Vol. 37, No. 4, 05.2014, p. 455-463.

Research output: Contribution to journal › Article › peer-review

Zhang, X, McGeoch, SC, Johnstone, AM, Holtrop, G, Sneddon, AA, Macrury, SM, Megson, IL, Pearson, DWM, Abraham, P, De Roos, B, Lobley, GE & O'Kennedy, N 2014, 'Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status', Journal of Thrombosis and Thrombolysis, vol. 37, no. 4, pp. 455-463. https://doi.org/10.1007/s11239-013-1000-2

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AU - Pearson, Donald W M

AU - Abraham, Prakash

AU - De Roos, Baukje

AU - Lobley, Gerald E

AU - O'Kennedy, Niamh

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N2 - This study investigated the impact of either type 2 diabetes or obesity, separately or in combination, on the absolute amounts of microparticles (MP) and the pathways by which these are associated with either condition. The concentrations of circulating MP derived from platelets (PMP), leukocytes (LMP) and monocytes (MMP), together with their specific activation markers, were compared in 30 subjects who were characterised across 4 cohorts as obese or type 2 diabetes. The subjects with type 2 diabetes had elevated concentrations of total PMP (P = 0.003), and PMP that were fibrinogen-positive (P = 0.04), tissue factor-positive (P < 0.001), P-selectin-positive (P = 0.03). Type 2 diabetes did not alter either total or activated LMP or MMP. Obesity per se did not impact on any MP measurement. Elevated concentrations of plasma PMP occurred in subjects with type 2 diabetes, whether they were obese or non-obese. In contrast, obesity in the absence of type 2 diabetes had no effect. The increased concentrations of specific marker-positive PMP in the subjects with diabetes might reflect potential pathways by which PMP may contribute to the pathogenesis of atherosclerosis and type 2 diabetes.

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ER -

Platelet-derived microparticle count and surface molecule expression differ between subjects with and without type 2 diabetes, independently of obesity status

Abstract

Bibliographical note

Keywords

UN SDGs

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Alan Sneddon

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