Platelet glycoprotein IIIa polymorphism HPA 1b (Pl(A2)): no association with platelet fibrinogen binding

D J Meiklejohn, S J Urbaniak, M Greaves

Research output: Contribution to journalArticle

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Abstract

The role of the platelet glycoprotein (GP) IIIa polymorphism HPA 1b (Pl(A2)) in the risk of arterial thrombosis is controversial. Mie investigated the effect of the Ib allele on platelet fibrinogen binding by flow cytometry. Samples from 35 healthy platelet and plasma donors possessing the Ib allele were compared with 35 1a/1a donors. We found no allele-dependent difference in percentage of platelets binding fibrinogen (P = 0.6), nor in mean cell fluorescence (P = 0.3) following stimulation with ADP. These results render it unlikely that any relationship between the Ib polymorphism and arterial thrombosis is mediated by a significant effect on fibrinogen binding.

Original languageEnglish
Pages (from-to)664-666
Number of pages3
JournalBritish Journal of Haematology
Volume105
Publication statusPublished - 1999

Keywords

  • glycoprotein IIIa
  • HPA 1b
  • platelet fibrinogen binding
  • FLOW-CYTOMETRY
  • WHOLE-BLOOD
  • ACTIVATION
  • THROMBOSIS
  • RECEPTOR

Cite this

Platelet glycoprotein IIIa polymorphism HPA 1b (Pl(A2)): no association with platelet fibrinogen binding. / Meiklejohn, D J ; Urbaniak, S J ; Greaves, M .

In: British Journal of Haematology, Vol. 105, 1999, p. 664-666.

Research output: Contribution to journalArticle

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abstract = "The role of the platelet glycoprotein (GP) IIIa polymorphism HPA 1b (Pl(A2)) in the risk of arterial thrombosis is controversial. Mie investigated the effect of the Ib allele on platelet fibrinogen binding by flow cytometry. Samples from 35 healthy platelet and plasma donors possessing the Ib allele were compared with 35 1a/1a donors. We found no allele-dependent difference in percentage of platelets binding fibrinogen (P = 0.6), nor in mean cell fluorescence (P = 0.3) following stimulation with ADP. These results render it unlikely that any relationship between the Ib polymorphism and arterial thrombosis is mediated by a significant effect on fibrinogen binding.",
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AB - The role of the platelet glycoprotein (GP) IIIa polymorphism HPA 1b (Pl(A2)) in the risk of arterial thrombosis is controversial. Mie investigated the effect of the Ib allele on platelet fibrinogen binding by flow cytometry. Samples from 35 healthy platelet and plasma donors possessing the Ib allele were compared with 35 1a/1a donors. We found no allele-dependent difference in percentage of platelets binding fibrinogen (P = 0.6), nor in mean cell fluorescence (P = 0.3) following stimulation with ADP. These results render it unlikely that any relationship between the Ib polymorphism and arterial thrombosis is mediated by a significant effect on fibrinogen binding.

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KW - ACTIVATION

KW - THROMBOSIS

KW - RECEPTOR

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