Platelet-Mediated Modulation of Fibrinolysis

Claire S Whyte, Joanne L Mitchell, Nicola J Mutch

Research output: Contribution to journalReview article

9 Citations (Scopus)
5 Downloads (Pure)

Abstract

Platelets are crucial to the hemostatic response. Their role in coagulation is well documented and they have been considered for some time to promote resistance of thrombi to fibrinolysis. Platelets confer resistance to lysis by promoting clot retraction of the immediate fibrin network and through release of plasminogen activator inhibitor-1 from their α-granules. However, recent developments in the field indicate that the role of platelets in fibrinolysis is much more diverse. Indeed, novel studies suggest that platelets form different subpopulations upon activation that play varied roles in regulating hemostasis. Likewise the developments in our understanding of thrombus formation, architecture, and changes in fibrin deposition and composition suggest that these different subpopulations of platelets may populate distinct areas within thrombi and potentially dictate the local hemostatic balance in these areas. This review will discuss the diverse roles of platelets in fibrinolysis and highlight the recent developments in the field and the contribution of both the intracellular pool of modulators as well as the membrane surface in regulating these processes.

Original languageEnglish
Pages (from-to)115-128
Number of pages14
JournalSeminars in Thrombosis and Hemostasis
Volume43
Issue number2
Early online date19 Feb 2017
DOIs
Publication statusPublished - Mar 2017

Fingerprint

Fibrinolysis
Blood Platelets
Thrombosis
Hemostatics
Fibrin
Clot Retraction
Plasminogen Activator Inhibitor 1
Hemostasis
Membranes

Keywords

  • platelets
  • fibrinolysis
  • factor XIII
  • plasminogen
  • fibrinogen

Cite this

Platelet-Mediated Modulation of Fibrinolysis. / Whyte, Claire S; Mitchell, Joanne L; Mutch, Nicola J.

In: Seminars in Thrombosis and Hemostasis, Vol. 43, No. 2, 03.2017, p. 115-128.

Research output: Contribution to journalReview article

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AB - Platelets are crucial to the hemostatic response. Their role in coagulation is well documented and they have been considered for some time to promote resistance of thrombi to fibrinolysis. Platelets confer resistance to lysis by promoting clot retraction of the immediate fibrin network and through release of plasminogen activator inhibitor-1 from their α-granules. However, recent developments in the field indicate that the role of platelets in fibrinolysis is much more diverse. Indeed, novel studies suggest that platelets form different subpopulations upon activation that play varied roles in regulating hemostasis. Likewise the developments in our understanding of thrombus formation, architecture, and changes in fibrin deposition and composition suggest that these different subpopulations of platelets may populate distinct areas within thrombi and potentially dictate the local hemostatic balance in these areas. This review will discuss the diverse roles of platelets in fibrinolysis and highlight the recent developments in the field and the contribution of both the intracellular pool of modulators as well as the membrane surface in regulating these processes.

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