Pleiotropic effects of risk factors in age-related macular degeneration and seemingly unrelated complex diseases

Christina Kiel, Bernhard H.F. Weber, Felix Grassmann*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Age-related macular degeneration (AMD) is a complex disease with both environmental and genetic factors influencing disease risk. Genome-wide case-control association studies, candidate gene analyses, and epidemiological studies reinforced the notion that AMD is predominantly a disease of an impaired complement system and an altered high-density lipoprotein (HDL) metabolism. Recent reports demonstrated the pleiotropic role of the complement system and HDL in complex diseases such as cardiovascular disease, autoimmune disorders, cancer, and Alzheimer’s disease. In light of these findings, we explore current evidence for a shared genetic and environmental risk of AMD and unrelated complex diseases based on epidemiological studies. Shared risk factors may indicate common pathways in disease pathology and thus may have implications for novel treatment options of AMD pathology.

Original languageEnglish
Title of host publicationRetinal Degenerative Diseases
EditorsJohn D Ash, Robert E Anderson, Matthew M LaVail, Catherine Bowes Rickman, Joe G Hollyfield
PublisherSpringer New York LLC
Pages247-255
Number of pages9
ISBN (Electronic)978-3-319-75402-4
ISBN (Print)978-3-319-75401-7
DOIs
Publication statusPublished - 3 May 2018

Publication series

NameAdvances in Experimental Medicine and Biology
Volume1074
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Keywords

  • Age-related macular degeneration
  • Autoimmune disease
  • Cancer
  • Cardiovascular disease
  • Cholesterol metabolism
  • Pleiotropy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Kiel, C., Weber, B. H. F., & Grassmann, F. (2018). Pleiotropic effects of risk factors in age-related macular degeneration and seemingly unrelated complex diseases. In J. D. Ash, R. E. Anderson, M. M. LaVail, C. B. Rickman, & J. G. Hollyfield (Eds.), Retinal Degenerative Diseases (pp. 247-255). (Advances in Experimental Medicine and Biology; Vol. 1074). Springer New York LLC. https://doi.org/10.1007/978-3-319-75402-4_30