Pneumonia and Risk of Serious Adverse Outcomes in Hospitalized Strokes in Thailand

Raphae S. Barlas, Allan B. Clark, Joao H. Bettencourt-Silva, Kittisak Sawanyawisuth, Kannikar Kongbunkiat, Narongrit Kasemsap, Somsak Tiamkao, Phyo Kyaw Myint (Corresponding Author)

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The impact of stroke associated pneumonia (SAP) on stroke complications is not well understood; we aimed to study the association between SAP and adverse outcomes including in-hospital mortality, prolonged length of stay and the risk of developing common serious complications (sepsis, respiratory failure, and convulsions). Methods: We retrospectively analyzed data from a cohort of 610,668 stroke patients drawn from the Universal Coverage Health Security Scheme (a national insurance database) in Thailand which covers ∼80% of the Thai population. Patients were hospitalized between October 2004 and January 2013. Results: Pneumonia was present in 9.6 % (n = 58,586) of patients. Aspiration pneumonia was present in 6.2% (n = 38,060) and nonaspiration pneumonia in 3.4% (n = 20,526). After adjusting for age, sex, stroke type, and comorbidities, patients with SAP had significantly higher odds of in-hospital mortality (odds ratio [OR] 2.90: 2.83-2.96), long length of stay (OR 13.11: 12.83-13.40), sepsis (OR 8.49: 8.22-8.76), respiratory failure (OR 4.37: 4.27-4.48), and convulsions (OR 2.09: 2.00-2.17). On subanalysis, patients with nonaspiration pneumonia were found to have higher odds of adverse outcomes compared to aspiration pneumonia; the corresponding ORs (95% confidence interval) for above outcomes were 1.25 (1.21-1.30), 2.40 (2.32-2.49), 1.34 (1.28-1.40), 1.80 (1.73-1.88), and 1.19 (1.11-1.28), respectively. Conclusions: SAP is associated with higher odds of inpatient mortality, long length of stay, and risk of developing serious stroke complications. Nonaspiration pneumonia is associated with significantly higher likelihood of adverse outcomes compared to aspiration pneumonia in this patient population. Early identification and treatment of SAP is vital in reducing adverse outcomes in acute stroke.
Original languageEnglish
Pages (from-to)1448-1454
Number of pages7
JournalJournal of Stroke and Cerebrovascular Diseases
Volume28
Issue number6
Early online date4 Apr 2019
DOIs
Publication statusPublished - Jun 2019

Keywords

  • Stroke
  • Stroke associated pneumonia
  • mortality
  • length of stay
  • complications
  • Mortality

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