Colorectal cancer is one of a number of cancers that may be amenable to prevention. The NSAIDs (nonsteroidal anti-inflammatory drugs) have been shown to be effective chemopreventative agents in humans, but their mechanism of action is not clear. The polyamines are cellular polycations that are essential for cell growth and are overproduced in cancer cells. It is our hypothesis that inhibition of polyamine metabolism is an integral part of the mechanism of cancer prevention mediated by NSAIDs.
|Number of pages||5|
|Journal||Biochemical Society Transactions|
|Issue number||Pt 2|
|Publication status||Published - Apr 2007|
- colorectal cancer
- non-steroidal anti-inflammatory drug (NSAID)