Polyamine metabolism and cancer prevention

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Colorectal cancer is one of a number of cancers that may be amenable to prevention. The NSAIDs (nonsteroidal anti-inflammatory drugs) have been shown to be effective chemopreventative agents in humans, but their mechanism of action is not clear. The polyamines are cellular polycations that are essential for cell growth and are overproduced in cancer cells. It is our hypothesis that inhibition of polyamine metabolism is an integral part of the mechanism of cancer prevention mediated by NSAIDs.

Original languageEnglish
Pages (from-to)364-368
Number of pages5
JournalBiochemical Society Transactions
Volume35
Issue numberPt 2
Publication statusPublished - Apr 2007

Keywords

  • chemoprevention
  • colorectal cancer
  • cytotoxicity
  • non-steroidal anti-inflammatory drug (NSAID)
  • polyamine
  • risk
  • adenomas
  • colon-cancer
  • randomized-trial
  • aspirin
  • cohort
  • cells

Cite this