Polyamine metabolism and cancer prevention

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13 Citations (Scopus)


Colorectal cancer is one of a number of cancers that may be amenable to prevention. The NSAIDs (nonsteroidal anti-inflammatory drugs) have been shown to be effective chemopreventative agents in humans, but their mechanism of action is not clear. The polyamines are cellular polycations that are essential for cell growth and are overproduced in cancer cells. It is our hypothesis that inhibition of polyamine metabolism is an integral part of the mechanism of cancer prevention mediated by NSAIDs.

Original languageEnglish
Pages (from-to)364-368
Number of pages5
JournalBiochemical Society Transactions
Issue numberPt 2
Publication statusPublished - Apr 2007


  • chemoprevention
  • colorectal cancer
  • cytotoxicity
  • non-steroidal anti-inflammatory drug (NSAID)
  • polyamine
  • risk
  • adenomas
  • colon-cancer
  • randomized-trial
  • aspirin
  • cohort
  • cells


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