Polygenic dissection of the bipolar phenotype

M. L. Hamshere, M. C. O'Donovan, I. R. Jones, L. Jones, G. Kirov, E. K. Green, V. Moskvina, D. Grozeva, N. Bass, A. McQuillin, H. Gurling, D. St Clair, A. H. Young, I. N. Ferrier, A. Farmer, P. McGuffin, P. Sklar, S. Purcell, P. A. Holmans, M. J. Owen & 1 others Nick Craddock*

*Corresponding author for this work

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: Recent data provide strong support for a substantial common polygenic contribution (i.e. many alleles each of small effect) to genetic susceptibility for schizophrenia and overlapping susceptibility for bipolar disorder. Aims: To test hypotheses about the relationship between schizophrenia and psychotic types of bipolar disorder. Method: Using a polygenic score analysis to test whether schizophrenia polygenic risk alleles, en masse, significantly discriminate between individuals with bipolar disorder with and without psychotic features. The primary sample included 1829 participants with bipolar disorder and the replication sample comprised 506 people with bipolar disorder. Results: The subset of participants with Research Diagnostic Criteria schizoaffective bipolar disorder (n = 277) were significantly discriminated from the remaining participants with bipolar disorder (n = 1552) in both the primary (P = 0.00059) and the replication data-sets (P = 0.0070). In contrast, those with psychotic bipolar disorder as a whole were not significantly different from those with non-psychotic bipolar disorder in either data-set. Conclusions: Genetic susceptibility influences at least two major domains of psychopathological variation in the schizophrenia-bipolar disorder clinical spectrum: one that relates to expression of a 'bipolar disorder-like' phenotype and one that is associated with expression of 'schizophrenia-like' psychotic symptoms.

Original languageEnglish
Pages (from-to)284-288
Number of pages5
JournalBritish Journal of Psychiatry
Volume198
Issue number4
DOIs
Publication statusPublished - 1 Apr 2011

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Bipolar Disorder
Dissection
Phenotype
Schizophrenia
Psychotic Disorders
Genetic Predisposition to Disease
Alleles

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Hamshere, M. L., O'Donovan, M. C., Jones, I. R., Jones, L., Kirov, G., Green, E. K., ... Craddock, N. (2011). Polygenic dissection of the bipolar phenotype. British Journal of Psychiatry, 198(4), 284-288. https://doi.org/10.1192/bjp.bp.110.087866

Polygenic dissection of the bipolar phenotype. / Hamshere, M. L.; O'Donovan, M. C.; Jones, I. R.; Jones, L.; Kirov, G.; Green, E. K.; Moskvina, V.; Grozeva, D.; Bass, N.; McQuillin, A.; Gurling, H.; St Clair, D.; Young, A. H.; Ferrier, I. N.; Farmer, A.; McGuffin, P.; Sklar, P.; Purcell, S.; Holmans, P. A.; Owen, M. J.; Craddock, Nick.

In: British Journal of Psychiatry, Vol. 198, No. 4, 01.04.2011, p. 284-288.

Research output: Contribution to journalArticle

Hamshere, ML, O'Donovan, MC, Jones, IR, Jones, L, Kirov, G, Green, EK, Moskvina, V, Grozeva, D, Bass, N, McQuillin, A, Gurling, H, St Clair, D, Young, AH, Ferrier, IN, Farmer, A, McGuffin, P, Sklar, P, Purcell, S, Holmans, PA, Owen, MJ & Craddock, N 2011, 'Polygenic dissection of the bipolar phenotype', British Journal of Psychiatry, vol. 198, no. 4, pp. 284-288. https://doi.org/10.1192/bjp.bp.110.087866
Hamshere ML, O'Donovan MC, Jones IR, Jones L, Kirov G, Green EK et al. Polygenic dissection of the bipolar phenotype. British Journal of Psychiatry. 2011 Apr 1;198(4):284-288. https://doi.org/10.1192/bjp.bp.110.087866
Hamshere, M. L. ; O'Donovan, M. C. ; Jones, I. R. ; Jones, L. ; Kirov, G. ; Green, E. K. ; Moskvina, V. ; Grozeva, D. ; Bass, N. ; McQuillin, A. ; Gurling, H. ; St Clair, D. ; Young, A. H. ; Ferrier, I. N. ; Farmer, A. ; McGuffin, P. ; Sklar, P. ; Purcell, S. ; Holmans, P. A. ; Owen, M. J. ; Craddock, Nick. / Polygenic dissection of the bipolar phenotype. In: British Journal of Psychiatry. 2011 ; Vol. 198, No. 4. pp. 284-288.
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