Population balance model based multi-objective optimization and robustness analysis of a continuous plug flow antisolvent crystallizer

Bradley J. Ridder, Aniruddha Majumder, Zoltan K. Nagy

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Crystallization is a major separation process in the pharmaceutical industry. Most crystallizations are performed batchwise, but there is great incentive for switching to continuous operation. We have investigated the modeling, simulation, optimization, and robustness of a multi-segmented, multi-addition plug-flow crystallizer (MSMA-PFC). The design accepts multiple antisolvent flows along its length, permitting localized control of supersaturation. A mass balance equation was used to track the depletion of dissolved solute (flufenamic acid), and a population balance equation for tracking the crystal size distribution. Multiobjective optimization was done using the antisolvent flowrates into each segment as decision variables. The genetic algorithm was used to calculate the Pareto frontiers for the two competing objectives of maximizing average crystal size (L43), and minimizing coefficient of variation (CV). The sensitivity of the Pareto frontier to variation in the growth and nucleation kinetic parameters was investigated. The robustness of a single solution was examined as well with respect to error in the kinetic parameters, as well as to errors in antisolvent flowrate.
Original languageEnglish
Title of host publicationAmerican Control Conference (ACC), 2014
PublisherIEEE Press
Pages3530 - 3535
Number of pages6
ISBN (Print)978-1-4799-3272-6
DOIs
Publication statusPublished - 6 Jun 2014
EventAmerican Control Conference (ACC), 2014 - Oragon, United States
Duration: 4 Jun 20146 Jun 2014

Conference

ConferenceAmerican Control Conference (ACC), 2014
CountryUnited States
CityOragon
Period4/06/146/06/14

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crystallization
crystal
kinetics
pharmaceutical industry
supersaturation
genetic algorithm
nucleation
solute
mass balance
incentive
acid
modeling
simulation
analysis
parameter
decision

Cite this

Population balance model based multi-objective optimization and robustness analysis of a continuous plug flow antisolvent crystallizer. / Ridder, Bradley J.; Majumder, Aniruddha; Nagy, Zoltan K.

American Control Conference (ACC), 2014 . IEEE Press, 2014. p. 3530 - 3535.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ridder, BJ, Majumder, A & Nagy, ZK 2014, Population balance model based multi-objective optimization and robustness analysis of a continuous plug flow antisolvent crystallizer. in American Control Conference (ACC), 2014 . IEEE Press, pp. 3530 - 3535, American Control Conference (ACC), 2014, Oragon, United States, 4/06/14. https://doi.org/10.1109/ACC.2014.6859425
Ridder, Bradley J. ; Majumder, Aniruddha ; Nagy, Zoltan K. / Population balance model based multi-objective optimization and robustness analysis of a continuous plug flow antisolvent crystallizer. American Control Conference (ACC), 2014 . IEEE Press, 2014. pp. 3530 - 3535
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