Population-based study of autoimmune conditions and the risk of specific lymphoid malignancies

Lesley A. Anderson, Shahinaz Gadalla, Lindsay M. Morton, Ola Landgren, Ruth Pfeiffer, Joan L. Warren, Sonja I. Berndt, Winnie Ricker, Ruth Parsons, Eric A. Engels

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166 Citations (Scopus)

Abstract

Some autoimmune conditions are associated with increased risk of lymphoid malignancies, but information on specific malignancy subtypes is limited. From the U.S. Surveillance Epidemiology and End Results-Medicare database, we selected 44,350 lymphoid malignancy cases (≥67 years) and 122,531 population-based controls. Logistic regression was used to derive odds ratios (ORs) comparing the prevalence of autoimmune conditions in cases and controls, by lymphoid malignancy subtype, adjusted for gender, age at malignancy/ selection, year of malignancy/selection, race and number of physician claims. The strongest associations observed by non-Hodgkin lymphoma (NHL) subtypes were diffuse large B-cell lymphoma with rheumatoid arthritis (OR 1.4, 95%CI 1.2-1.5) and Sjögren syndrome (2.0, 1.5-2.8); T-cell lymphoma with hemolytic anemia (9.7, 4.3-22), psoriasis (3.1, 2.5-4.0), discoid lupus erythematosus (4.4, 2.3-8.4) and celiac disease (5.0, 2.4-14.); and marginal zone lymphoma with Sjögren syndrome (6.6, 4.6-9.5), systemic lupus erythematosus (2.8, 1.7-4.7) and hemolytic anemia (7.4, 3.1-18). Hodgkin lymphoma was associated with systemic lupus erythematosus (3.5, 1.9-6.7). Multiple myeloma was associated only with pernicious anemia (1.5, 1.3-1.7). Several autoimmune conditions were associated with increased risk of lymphoid neoplasms, especially NHLs of diffuse large B-cell, marginal zone and T-cell subtypes. These results support a mechanism whereby chronic antigenic stimulation leads to lymphoid malignancy.

Original languageEnglish
Pages (from-to)398-405
Number of pages8
JournalInternational Journal of Cancer
Volume125
Issue number2
DOIs
Publication statusPublished - 15 Jul 2009

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Keywords

  • Autoimmune
  • Chronic lymphocytic leukemia
  • Epidemiology
  • Lymphoma
  • Risk

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Anderson, L. A., Gadalla, S., Morton, L. M., Landgren, O., Pfeiffer, R., Warren, J. L., Berndt, S. I., Ricker, W., Parsons, R., & Engels, E. A. (2009). Population-based study of autoimmune conditions and the risk of specific lymphoid malignancies. International Journal of Cancer, 125(2), 398-405. https://doi.org/10.1002/ijc.24287