Population-Genetics of Mycobacterium Tuberculosis Complex in Scotland Analyzed by Pulsed Field Gel Electrophoresis

Shona Olson, Ken J. Forbes, B WATT, Thomas Hugh Pennington

Research output: Contribution to journalArticle

Abstract

The results of typing of 121 strains in the Mycobacterium tuberculosis complex by PFGE are presented. Every isolate from patients in Scotland over a S-month period for M. tuberculosis and for 1 year for M. bovis were included along with several laboratory strains including those of BCG. The PFGE results suggest that the population structure of all the strains in this complex is distinctly simple with limited genetic diversity and also suggest that M. bovis is not a distinct species.

Original languageEnglish
Pages (from-to)153-160
Number of pages8
JournalEpidemiology and Infection
Volume114
Issue number1
Publication statusPublished - Feb 1995

Keywords

  • restriction fragment patterns
  • deoxyribonucleic-acid relatedness
  • BOVIS BCG
  • endonuclease analysis
  • DNA
  • strains
  • identification
  • seals
  • heterogeneity
  • polymorphism

Cite this

Population-Genetics of Mycobacterium Tuberculosis Complex in Scotland Analyzed by Pulsed Field Gel Electrophoresis. / Olson, Shona; Forbes, Ken J.; WATT, B ; Pennington, Thomas Hugh.

In: Epidemiology and Infection, Vol. 114, No. 1, 02.1995, p. 153-160.

Research output: Contribution to journalArticle

@article{ecacf251e63344e49d2a5d8ee07d22b6,
title = "Population-Genetics of Mycobacterium Tuberculosis Complex in Scotland Analyzed by Pulsed Field Gel Electrophoresis",
abstract = "The results of typing of 121 strains in the Mycobacterium tuberculosis complex by PFGE are presented. Every isolate from patients in Scotland over a S-month period for M. tuberculosis and for 1 year for M. bovis were included along with several laboratory strains including those of BCG. The PFGE results suggest that the population structure of all the strains in this complex is distinctly simple with limited genetic diversity and also suggest that M. bovis is not a distinct species.",
keywords = "restriction fragment patterns, deoxyribonucleic-acid relatedness, BOVIS BCG, endonuclease analysis, DNA, strains, identification, seals, heterogeneity, polymorphism",
author = "Shona Olson and Forbes, {Ken J.} and B WATT and Pennington, {Thomas Hugh}",
year = "1995",
month = "2",
language = "English",
volume = "114",
pages = "153--160",
journal = "Epidemiology and Infection",
issn = "0950-2688",
publisher = "Cambridge University Press",
number = "1",

}

TY - JOUR

T1 - Population-Genetics of Mycobacterium Tuberculosis Complex in Scotland Analyzed by Pulsed Field Gel Electrophoresis

AU - Olson, Shona

AU - Forbes, Ken J.

AU - WATT, B

AU - Pennington, Thomas Hugh

PY - 1995/2

Y1 - 1995/2

N2 - The results of typing of 121 strains in the Mycobacterium tuberculosis complex by PFGE are presented. Every isolate from patients in Scotland over a S-month period for M. tuberculosis and for 1 year for M. bovis were included along with several laboratory strains including those of BCG. The PFGE results suggest that the population structure of all the strains in this complex is distinctly simple with limited genetic diversity and also suggest that M. bovis is not a distinct species.

AB - The results of typing of 121 strains in the Mycobacterium tuberculosis complex by PFGE are presented. Every isolate from patients in Scotland over a S-month period for M. tuberculosis and for 1 year for M. bovis were included along with several laboratory strains including those of BCG. The PFGE results suggest that the population structure of all the strains in this complex is distinctly simple with limited genetic diversity and also suggest that M. bovis is not a distinct species.

KW - restriction fragment patterns

KW - deoxyribonucleic-acid relatedness

KW - BOVIS BCG

KW - endonuclease analysis

KW - DNA

KW - strains

KW - identification

KW - seals

KW - heterogeneity

KW - polymorphism

M3 - Article

VL - 114

SP - 153

EP - 160

JO - Epidemiology and Infection

JF - Epidemiology and Infection

SN - 0950-2688

IS - 1

ER -