Positional Information – a concept underpinning our understanding of developmental biology

Neil Vargesson

doi:10.1002/dvdy.116

Positional Information – a concept underpinning our understanding of developmental biology

Neil Vargesson^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

1 Downloads (Pure)

Abstract

It is now 50 years since Lewis Wolpert published the paper in which he set out the concept of Positional Information to explain how spatial patterns of cellular differentiation are generated. This concept has provided a universal model for pattern formation in embryonic development and regeneration and become part of the fabric of the field of developmental biology. Here I outline how Wolpert devised the concept of Positional Information and describe landmark studies from his lab investigating how Positional Information is specified in the developing chick limb.

Original language	English
Pages (from-to)	298-312
Number of pages	15
Journal	Developmental Dynamics
Volume	249
Issue number	3
Early online date	21 Oct 2019
DOIs	https://doi.org/10.1002/dvdy.116
Publication status	Published - 1 Mar 2020

Keywords

Lewis Wolpert
Hydra
Sea urchin
Chick limb development
French flag model
Progress Zone
Morphogen gradient
Positional value
Pattern formation
chick limb development
progress zone
sea urchin
morphogen gradient
pattern formation
positional value
DORSOVENTRAL PATTERN
BICOID PROTEIN
POLARIZING REGION
CHICK LIMB
GENE-EXPRESSION
DORSAL PROTEIN
VERTEBRATE LIMB
PATTERN-FORMATION
ANTEROPOSTERIOR AXIS
SONIC-HEDGEHOG

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Vargeson_DevDyn_AAM
This is the peer reviewed version of the following article: Vargesson, N. Positional Information—A concept underpinning our understanding of developmental biology. Developmental Dynamics. 2020; 249: 298– 312., which has been published in final form at https://doi.org/10.1002/dvdy.116. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.
Accepted author manuscript, 3.78 MBLicence: Unspecified

Cite this

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title = "Positional Information – a concept underpinning our understanding of developmental biology",

abstract = "It is now 50 years since Lewis Wolpert published the paper in which he set out the concept of Positional Information to explain how spatial patterns of cellular differentiation are generated. This concept has provided a universal model for pattern formation in embryonic development and regeneration and become part of the fabric of the field of developmental biology. Here I outline how Wolpert devised the concept of Positional Information and describe landmark studies from his lab investigating how Positional Information is specified in the developing chick limb.",

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KW - Sea urchin

KW - Chick limb development

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KW - GENE-EXPRESSION

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Positional Information – a concept underpinning our understanding of developmental biology

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Keywords

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