Positional Information – a concept underpinning our understanding of developmental biology

Neil Vargesson* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

It is now 50 years since Lewis Wolpert published the paper in which he set out the concept of Positional Information to explain how spatial patterns of cellular differentiation are generated. This concept has provided a universal model for pattern formation in embryonic development and regeneration and become part of the fabric of the field of developmental biology. Here I outline how Wolpert devised the concept of Positional Information and describe landmark studies from his lab investigating how Positional Information is specified in the developing chick limb.
Original languageEnglish
Pages (from-to)298-312
Number of pages15
JournalDevelopmental Dynamics
Volume249
Issue number3
Early online date21 Oct 2019
DOIs
Publication statusPublished - 1 Mar 2020

Keywords

  • Lewis Wolpert
  • Hydra
  • Sea urchin
  • Chick limb development
  • French flag model
  • Progress Zone
  • Morphogen gradient
  • Positional value
  • Pattern formation
  • chick limb development
  • progress zone
  • sea urchin
  • morphogen gradient
  • pattern formation
  • positional value
  • DORSOVENTRAL PATTERN
  • BICOID PROTEIN
  • POLARIZING REGION
  • CHICK LIMB
  • GENE-EXPRESSION
  • DORSAL PROTEIN
  • VERTEBRATE LIMB
  • PATTERN-FORMATION
  • ANTEROPOSTERIOR AXIS
  • SONIC-HEDGEHOG

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