Positional Information – a concept underpinning our understanding of developmental biology

Neil Vargesson (Corresponding Author)

Research output: Contribution to journalArticle

Abstract

It is now 50 years since Lewis Wolpert published the paper in which he set out the concept of Positional Information to explain how spatial patterns of cellular differentiation are generated. This concept has provided a universal model for pattern formation in embryonic development and regeneration and become part of the fabric of the field of developmental biology. Here I outline how Wolpert devised the concept of Positional Information and describe landmark studies from his lab investigating how Positional Information is specified in the developing chick limb.
Original languageEnglish
JournalDevelopmental Dynamics
Early online date21 Oct 2019
DOIs
Publication statusE-pub ahead of print - 21 Oct 2019

Fingerprint

Developmental Biology
Embryonic Development
Regeneration
Extremities

Keywords

  • Lewis Wolpert
  • Hydra
  • Sea urchin
  • Chick limb development
  • French flag model
  • Progress Zone
  • Morphogen gradient
  • Positional value
  • Pattern formation
  • chick limb development
  • progress zone
  • sea urchin
  • morphogen gradient
  • pattern formation
  • positional value

ASJC Scopus subject areas

  • Developmental Biology

Cite this

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