Possible link between Hg and Cd accumulation in the brain of long-finned pilot whales (Globicephala melas)

Zuzana Gajdosechova, Andrew Brownlow, Nicolas T. Cottin, Mariana Fernandes, Fiona L. Read, Dagmar S. Urgast, Andrea Raab, Jörg Feldmann, Eva M. Krupp

Research output: Contribution to journalArticle

10 Citations (Scopus)
7 Downloads (Pure)

Abstract

The bioaccumulation of metals was investigated by analysis of liver, kidney, muscle and brain tissue of a pod of 21 long-finned pilot whales (Globicephala melas) of all ages stranded in Scotland, UK. The results are the first to report cadmium (Cd) passage through the blood-brain barrier of pilot whales and provide a comprehensive study of the long-term (up to 35years) mammalian exposure to the environmental pollutants. Additionally, linear accumulation of mercury (Hg) was observed in all studied tissues, whereas for Cd this was only observed in the liver. Total Hg concentration above the upper neurochemical threshold was found in the sub-adult and adult brains and methylmercury (MeHg) of 2.2mg/kg was found in the brain of one individual. Inter-elemental analysis showed significant positive correlations of Hg with selenium (Se) and Cd with Se in all studied tissues. Furthermore, differences in the elemental concentrations in the liver and brain tissues were found between juvenile, sub-adult and adult groups. The highest concentrations of manganese, iron, zinc, Se, Hg and MeHg were noted in the livers, whereas Cd predominantly accumulated in the kidneys. High concentrations of Hg and Cd in the tissues of pilot whales presented in this study reflect ever increasing toxic stress on marine mammals.

Original languageEnglish
Pages (from-to)407-413
Number of pages7
JournalScience of the Total Environment
Volume545-546
Early online date31 Dec 2015
DOIs
Publication statusPublished - 1 Mar 2016

Fingerprint

Cadmium
whale
brain
Brain
cadmium
Liver
Tissue
Selenium
selenium
Environmental Pollutants
Bioaccumulation
Mammals
Poisons
marine mammal
methylmercury
Manganese
Mercury
bioaccumulation
Muscle
Zinc

Keywords

  • marine mammals
  • trace elements
  • bioaccumulation
  • blood–brain barrier
  • Scotland

Cite this

Possible link between Hg and Cd accumulation in the brain of long-finned pilot whales (Globicephala melas). / Gajdosechova, Zuzana; Brownlow, Andrew; Cottin, Nicolas T.; Fernandes, Mariana; Read, Fiona L.; Urgast, Dagmar S.; Raab, Andrea; Feldmann, Jörg; Krupp, Eva M.

In: Science of the Total Environment, Vol. 545-546, 01.03.2016, p. 407-413.

Research output: Contribution to journalArticle

Gajdosechova, Zuzana ; Brownlow, Andrew ; Cottin, Nicolas T. ; Fernandes, Mariana ; Read, Fiona L. ; Urgast, Dagmar S. ; Raab, Andrea ; Feldmann, Jörg ; Krupp, Eva M. / Possible link between Hg and Cd accumulation in the brain of long-finned pilot whales (Globicephala melas). In: Science of the Total Environment. 2016 ; Vol. 545-546. pp. 407-413.
@article{08bcf88952dc438088e955b070f24317,
title = "Possible link between Hg and Cd accumulation in the brain of long-finned pilot whales (Globicephala melas)",
abstract = "The bioaccumulation of metals was investigated by analysis of liver, kidney, muscle and brain tissue of a pod of 21 long-finned pilot whales (Globicephala melas) of all ages stranded in Scotland, UK. The results are the first to report cadmium (Cd) passage through the blood-brain barrier of pilot whales and provide a comprehensive study of the long-term (up to 35years) mammalian exposure to the environmental pollutants. Additionally, linear accumulation of mercury (Hg) was observed in all studied tissues, whereas for Cd this was only observed in the liver. Total Hg concentration above the upper neurochemical threshold was found in the sub-adult and adult brains and methylmercury (MeHg) of 2.2mg/kg was found in the brain of one individual. Inter-elemental analysis showed significant positive correlations of Hg with selenium (Se) and Cd with Se in all studied tissues. Furthermore, differences in the elemental concentrations in the liver and brain tissues were found between juvenile, sub-adult and adult groups. The highest concentrations of manganese, iron, zinc, Se, Hg and MeHg were noted in the livers, whereas Cd predominantly accumulated in the kidneys. High concentrations of Hg and Cd in the tissues of pilot whales presented in this study reflect ever increasing toxic stress on marine mammals.",
keywords = "marine mammals, trace elements, bioaccumulation, blood–brain barrier, Scotland",
author = "Zuzana Gajdosechova and Andrew Brownlow and Cottin, {Nicolas T.} and Mariana Fernandes and Read, {Fiona L.} and Urgast, {Dagmar S.} and Andrea Raab and J{\"o}rg Feldmann and Krupp, {Eva M.}",
note = "Acknowledgements M. M. Lawan for his helpful discussions about Se and advice on ICP-MS. C. C. Brombach for his introduction to CV-AFS and to D. Bellis for valuable comments and reviewing the English language in the manuscript. ZG would also like to thank the College of Physical Sciences at the University of Aberdeen and Chevron USA for the provided studentship. FLR and AB acknowledge Scottish Marine Animal Stranding Scheme and Marine Scotland for the funding.",
year = "2016",
month = "3",
day = "1",
doi = "10.1016/j.scitotenv.2015.12.082",
language = "English",
volume = "545-546",
pages = "407--413",
journal = "Science of the Total Environment",
issn = "0048-9697",
publisher = "Elsevier",

}

TY - JOUR

T1 - Possible link between Hg and Cd accumulation in the brain of long-finned pilot whales (Globicephala melas)

AU - Gajdosechova, Zuzana

AU - Brownlow, Andrew

AU - Cottin, Nicolas T.

AU - Fernandes, Mariana

AU - Read, Fiona L.

AU - Urgast, Dagmar S.

AU - Raab, Andrea

AU - Feldmann, Jörg

AU - Krupp, Eva M.

N1 - Acknowledgements M. M. Lawan for his helpful discussions about Se and advice on ICP-MS. C. C. Brombach for his introduction to CV-AFS and to D. Bellis for valuable comments and reviewing the English language in the manuscript. ZG would also like to thank the College of Physical Sciences at the University of Aberdeen and Chevron USA for the provided studentship. FLR and AB acknowledge Scottish Marine Animal Stranding Scheme and Marine Scotland for the funding.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - The bioaccumulation of metals was investigated by analysis of liver, kidney, muscle and brain tissue of a pod of 21 long-finned pilot whales (Globicephala melas) of all ages stranded in Scotland, UK. The results are the first to report cadmium (Cd) passage through the blood-brain barrier of pilot whales and provide a comprehensive study of the long-term (up to 35years) mammalian exposure to the environmental pollutants. Additionally, linear accumulation of mercury (Hg) was observed in all studied tissues, whereas for Cd this was only observed in the liver. Total Hg concentration above the upper neurochemical threshold was found in the sub-adult and adult brains and methylmercury (MeHg) of 2.2mg/kg was found in the brain of one individual. Inter-elemental analysis showed significant positive correlations of Hg with selenium (Se) and Cd with Se in all studied tissues. Furthermore, differences in the elemental concentrations in the liver and brain tissues were found between juvenile, sub-adult and adult groups. The highest concentrations of manganese, iron, zinc, Se, Hg and MeHg were noted in the livers, whereas Cd predominantly accumulated in the kidneys. High concentrations of Hg and Cd in the tissues of pilot whales presented in this study reflect ever increasing toxic stress on marine mammals.

AB - The bioaccumulation of metals was investigated by analysis of liver, kidney, muscle and brain tissue of a pod of 21 long-finned pilot whales (Globicephala melas) of all ages stranded in Scotland, UK. The results are the first to report cadmium (Cd) passage through the blood-brain barrier of pilot whales and provide a comprehensive study of the long-term (up to 35years) mammalian exposure to the environmental pollutants. Additionally, linear accumulation of mercury (Hg) was observed in all studied tissues, whereas for Cd this was only observed in the liver. Total Hg concentration above the upper neurochemical threshold was found in the sub-adult and adult brains and methylmercury (MeHg) of 2.2mg/kg was found in the brain of one individual. Inter-elemental analysis showed significant positive correlations of Hg with selenium (Se) and Cd with Se in all studied tissues. Furthermore, differences in the elemental concentrations in the liver and brain tissues were found between juvenile, sub-adult and adult groups. The highest concentrations of manganese, iron, zinc, Se, Hg and MeHg were noted in the livers, whereas Cd predominantly accumulated in the kidneys. High concentrations of Hg and Cd in the tissues of pilot whales presented in this study reflect ever increasing toxic stress on marine mammals.

KW - marine mammals

KW - trace elements

KW - bioaccumulation

KW - blood–brain barrier

KW - Scotland

U2 - 10.1016/j.scitotenv.2015.12.082

DO - 10.1016/j.scitotenv.2015.12.082

M3 - Article

VL - 545-546

SP - 407

EP - 413

JO - Science of the Total Environment

JF - Science of the Total Environment

SN - 0048-9697

ER -