Post-transcriptional control of animal histone gene expression: not so different after all...

Pamela Nicholson, Berndt Marino Muller

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Histone proteins are essential components of eukaryotic chromosomes. The expression of histone genes is cell cycle controlled and coupled to DNA replication, to ensure the packaging of replicated DNA into chromatin. The post-transcriptional control of histone gene expression is a key element in this coupling to DNA replication. It involves mRNA 30 end formation by histone-specific nuclear RNA processing, which produces mRNAs lacking a poly(A) tail, translation and mRNA stability control. This requires several histone-specific trans-acting factors and was thought to be a special case. Here we review recent observations that now reveal that many of the factors involved are shared with processing, translation and degradation of poly(A) mRNA.

Original languageEnglish
Pages (from-to)721-725
Number of pages5
JournalMolecular BioSystems
Volume4
Issue number7
Early online date17 Apr 2008
DOIs
Publication statusPublished - 2008

Keywords

  • Animals
  • Caenorhabditis elegans
  • Cell Nucleus
  • Drosophila melanogaster
  • Histones
  • Models, Biological
  • Poly A
  • RNA Processing, Post-Transcriptional
  • RNA Stability
  • RNA, Messenger

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