Posttranslational modifications of proteins in the pathobiology of medically relevant fungi

Michelle D Leach, Alistair J P Brown

Research output: Contribution to journalLiterature review

40 Citations (Scopus)
4 Downloads (Pure)

Abstract

Posttranslational modifications of proteins drive a wide variety of cellular processes in eukaryotes, regulating cell growth and division as well as adaptive and developmental processes. With regard to the fungal kingdom, most information about posttranslational modifications has been generated through studies of the model yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe, where, for example, the roles of protein phosphorylation, glycosylation, acetylation, ubiquitination, sumoylation, and neddylation have been dissected. More recently, information has begun to emerge for the medically important fungal pathogens Candida albicans, Aspergillus fumigatus, and Cryptococcus neoformans, highlighting the relevance of posttranslational modifications for virulence. We review the available literature on protein modifications in fungal pathogens, focusing in particular upon the reversible peptide modifications sumoylation, ubiquitination, and neddylation.
Original languageEnglish
Pages (from-to)98-108
Number of pages11
JournalEukaryotic Cell
Volume11
Issue number2
Early online date1 Dec 2011
DOIs
Publication statusPublished - Feb 2012

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Post Translational Protein Processing
Sumoylation
Fungi
Ubiquitination
Proteins
Cryptococcus neoformans
Aspergillus fumigatus
Schizosaccharomyces
Acetylation
Eukaryota
Candida albicans
Glycosylation
Cell Division
Virulence
Saccharomyces cerevisiae
Yeasts
Phosphorylation
Peptides
Growth

Cite this

Posttranslational modifications of proteins in the pathobiology of medically relevant fungi. / Leach, Michelle D; Brown, Alistair J P.

In: Eukaryotic Cell, Vol. 11, No. 2, 02.2012, p. 98-108.

Research output: Contribution to journalLiterature review

Leach, Michelle D ; Brown, Alistair J P. / Posttranslational modifications of proteins in the pathobiology of medically relevant fungi. In: Eukaryotic Cell. 2012 ; Vol. 11, No. 2. pp. 98-108.
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