Potential Benefit of Lymph Node Dissection During Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the European Association of Urology Guidelines Panel on Non-muscle-invasive Bladder Cancer

Jose Luis Dominguez-Escrig (Corresponding Author), Benoit Peyronnet, Thomas Seisen, Harman M Bruins, Cathy Yuhong Yuan, Marko Babjuk, Andreas Böhle, Maximilian Burger, Eva M Compérat, Paolo Gontero, Thomas Lam, Steven MacLennan, Hugh Mostafid, Joan Palou, Bas W G van Rhijn, Richard J Sylvester, Richard Zigeuner, Shahrokh F Shariat, Morgan Rouprêt

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

CONTEXT: The oncological efficacy of routine lymphadenectomy (lymph node dissection [LND]) at the time of radical nephroureterectomy (RNU) remains controversial.

OBJECTIVE: To systematically review the available literature assessing the impact of LND in upper tract urothelial carcinoma (UTUC) patients.

EVIDENCE ACQUISITION: Embase, Medline, and Cochrane databases were searched for all studies comparing outcomes of patients undergoing RNU without LND versus any form of LND. We identified nine retrospective studies eligible for inclusion in this systematic review. We took cancer-specific survival (CSS) as the primary end point, and performed a narrative review and risk of bias assessment.

EVIDENCE SYNTHESIS: Six studies compared outcomes of no LND versus LND. Three studies compared complete LND versus incomplete LND versus no LND. The incidence of pN+ in patients with high-stage (≥pT2) tumours ranged from 14.3% to 40%. Pre- and postoperative characteristics differed among the study groups, potentially biasing the results, as demonstrated by the risk of bias assessment, potentially favouring the LND group. Oncological outcomes such as cancer-specific, overall, recurrence-free, and metastasis-free survival were reviewed, demonstrating a survival benefit with LND in high-stage disease of the renal pelvis.

CONCLUSIONS: Template-based and complete LND improves CSS in patients with high-stage (≥pT2) UTUC and reduces the risk of local recurrence. The impact of LND in ureteral tumours remains uncertain.

PATIENT SUMMARY: Studies comparing radical nephroureterectomy with or without the removal of nodes (lymph node dissection [LND]) were analysed. LND improves survival in patients with high-stage disease of the renal pelvis, if it is performed according to an anatomical template-based approach.

Original languageEnglish
Pages (from-to)224-241
Number of pages18
JournalEuropean Urology Focus
Volume5
Issue number2
Early online date20 Nov 2017
DOIs
Publication statusPublished - Mar 2019

    Fingerprint

Keywords

  • Journal Article
  • Recurrence
  • Urothelial carcinoma
  • Renal pelvis
  • Ureter
  • Survival Nodes
  • Metastasis
  • Survival
  • Nodes
  • SURVIVAL
  • METAANALYSIS
  • UPPER URINARY-TRACT
  • CLINICAL-TRIAL
  • IMPACT
  • NEOADJUVANT CHEMOTHERAPY
  • TRANSITIONAL-CELL CARCINOMA
  • TEMPLATE-BASED LYMPHADENECTOMY
  • CYSTECTOMY
  • ONCOLOGICAL OUTCOMES

ASJC Scopus subject areas

  • Urology

Cite this

Dominguez-Escrig, J. L., Peyronnet, B., Seisen, T., Bruins, H. M., Yuan, C. Y., Babjuk, M., Böhle, A., Burger, M., Compérat, E. M., Gontero, P., Lam, T., MacLennan, S., Mostafid, H., Palou, J., van Rhijn, B. W. G., Sylvester, R. J., Zigeuner, R., Shariat, S. F., & Rouprêt, M. (2019). Potential Benefit of Lymph Node Dissection During Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: A Systematic Review by the European Association of Urology Guidelines Panel on Non-muscle-invasive Bladder Cancer. European Urology Focus, 5(2), 224-241. https://doi.org/10.1016/j.euf.2017.09.015