Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

Samira Anwar (Corresponding Author), Mintu Nath, Aarti Patel, Helena Lee, Samantha Brown, Irene Gottlob, Frank A. Proudlock

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate dynamic foveal morphology with postmenstrual age (PMA), in preterm infants with and without retinopathy of prematurity (ROP) using hand-held optical coherence tomography (HH-OCT), adjusting for gestational age (GA) and birthweight (BW).


Methods: Prospective mixed cross-sectional / longitudinal observational study of 87 participants (23 to 36 weeks GA; n=30 with, n=57 without ROP) using HH-OCT images (n=278) acquired between 31 to 44 weeks PMA excluding treated ROP. Measurements included foveal width, area, depth, central foveal thickness (CFT), maximum slope and parafoveal retinal thickness (pRT) at 1000 µm nasal and temporal to the central fovea.


Results: ROP was significantly correlated with only foveal width in either GA or BW adjusted statistical models. In contrast, severity of prematurity (GA, BW) correlated with foveal area (p<0.005), depth (p≤0.001) and slope (p<0.01) although CFT (p=0.007) and pRT (p<0.001) correlated with GA but not BW.


Conclusions: Foveal width is independent of GA and BW with potential in ROP
screening assessment using HH-OCT. Foveal morphology could be graded in
prematurity during development, with possible implications for future management of preterm infants.
Original languageEnglish
Number of pages11
JournalRetina
Early online date24 Jul 2019
DOIs
Publication statusE-pub ahead of print - 24 Jul 2019

Keywords

  • Foveal Morphology
  • hand-held Optical Coherence Tomography
  • prematurity
  • preterm infant
  • retinopathy of prematurity

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