Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

Samira Anwar (Corresponding Author), Mintu Nath, Aarti Patel, Helena Lee, Samantha Brown, Irene Gottlob, Frank A. Proudlock

Research output: Contribution to journalArticle

Abstract

Purpose: To investigate dynamic foveal morphology with postmenstrual age (PMA), in preterm infants with and without retinopathy of prematurity (ROP) using hand-held optical coherence tomography (HH-OCT), adjusting for gestational age (GA) and birthweight (BW).


Methods: Prospective mixed cross-sectional / longitudinal observational study of 87 participants (23 to 36 weeks GA; n=30 with, n=57 without ROP) using HH-OCT images (n=278) acquired between 31 to 44 weeks PMA excluding treated ROP. Measurements included foveal width, area, depth, central foveal thickness (CFT), maximum slope and parafoveal retinal thickness (pRT) at 1000 µm nasal and temporal to the central fovea.


Results: ROP was significantly correlated with only foveal width in either GA or BW adjusted statistical models. In contrast, severity of prematurity (GA, BW) correlated with foveal area (p<0.005), depth (p≤0.001) and slope (p<0.01) although CFT (p=0.007) and pRT (p<0.001) correlated with GA but not BW.


Conclusions: Foveal width is independent of GA and BW with potential in ROP
screening assessment using HH-OCT. Foveal morphology could be graded in
prematurity during development, with possible implications for future management of preterm infants.
Original languageEnglish
JournalRetina
Early online date24 Jul 2019
DOIs
Publication statusE-pub ahead of print - 24 Jul 2019

Fingerprint

Retinopathy of Prematurity
Optical Coherence Tomography
Premature Infants
Gestational Age
Hand
Statistical Models
Nose
Observational Studies
Longitudinal Studies

Keywords

  • Foveal Morphology
  • hand-held Optical Coherence Tomography
  • prematurity
  • preterm infant
  • retinopathy of prematurity

Cite this

Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening. / Anwar, Samira (Corresponding Author); Nath, Mintu; Patel, Aarti; Lee, Helena; Brown, Samantha; Gottlob, Irene; Proudlock, Frank A.

In: Retina, 24.07.2019.

Research output: Contribution to journalArticle

Anwar, Samira ; Nath, Mintu ; Patel, Aarti ; Lee, Helena ; Brown, Samantha ; Gottlob, Irene ; Proudlock, Frank A. / Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening. In: Retina. 2019.
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title = "Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening",
abstract = "Purpose: To investigate dynamic foveal morphology with postmenstrual age (PMA), in preterm infants with and without retinopathy of prematurity (ROP) using hand-held optical coherence tomography (HH-OCT), adjusting for gestational age (GA) and birthweight (BW).Methods: Prospective mixed cross-sectional / longitudinal observational study of 87 participants (23 to 36 weeks GA; n=30 with, n=57 without ROP) using HH-OCT images (n=278) acquired between 31 to 44 weeks PMA excluding treated ROP. Measurements included foveal width, area, depth, central foveal thickness (CFT), maximum slope and parafoveal retinal thickness (pRT) at 1000 µm nasal and temporal to the central fovea.Results: ROP was significantly correlated with only foveal width in either GA or BW adjusted statistical models. In contrast, severity of prematurity (GA, BW) correlated with foveal area (p<0.005), depth (p≤0.001) and slope (p<0.01) although CFT (p=0.007) and pRT (p<0.001) correlated with GA but not BW.Conclusions: Foveal width is independent of GA and BW with potential in ROPscreening assessment using HH-OCT. Foveal morphology could be graded inprematurity during development, with possible implications for future management of preterm infants.",
keywords = "Foveal Morphology, hand-held Optical Coherence Tomography, prematurity, preterm infant, retinopathy of prematurity",
author = "Samira Anwar and Mintu Nath and Aarti Patel and Helena Lee and Samantha Brown and Irene Gottlob and Proudlock, {Frank A.}",
note = "Financial Support: Medical Research Council, London, UK (grant number: MR/N004566/1 and MR/J004189/1), Ulverscroft Foundation, Leicester, UK, Nystagmus Network UK. Acknowledgements: The authors acknowledge the assistance of Deputy Sister Hima Thanki in assisting with the acquisition of HH-OCT images and the Staff of the University Hospitals of Leicester Neonatal Service in supporting the infants during the imaging sessions.",
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T1 - Potential Utility of Foveal Morphology in Preterm Infants Measured using Hand-Held Optical Coherence Tomography in Retinopathy of Prematurity Screening

AU - Anwar, Samira

AU - Nath, Mintu

AU - Patel, Aarti

AU - Lee, Helena

AU - Brown, Samantha

AU - Gottlob, Irene

AU - Proudlock, Frank A.

N1 - Financial Support: Medical Research Council, London, UK (grant number: MR/N004566/1 and MR/J004189/1), Ulverscroft Foundation, Leicester, UK, Nystagmus Network UK. Acknowledgements: The authors acknowledge the assistance of Deputy Sister Hima Thanki in assisting with the acquisition of HH-OCT images and the Staff of the University Hospitals of Leicester Neonatal Service in supporting the infants during the imaging sessions.

PY - 2019/7/24

Y1 - 2019/7/24

N2 - Purpose: To investigate dynamic foveal morphology with postmenstrual age (PMA), in preterm infants with and without retinopathy of prematurity (ROP) using hand-held optical coherence tomography (HH-OCT), adjusting for gestational age (GA) and birthweight (BW).Methods: Prospective mixed cross-sectional / longitudinal observational study of 87 participants (23 to 36 weeks GA; n=30 with, n=57 without ROP) using HH-OCT images (n=278) acquired between 31 to 44 weeks PMA excluding treated ROP. Measurements included foveal width, area, depth, central foveal thickness (CFT), maximum slope and parafoveal retinal thickness (pRT) at 1000 µm nasal and temporal to the central fovea.Results: ROP was significantly correlated with only foveal width in either GA or BW adjusted statistical models. In contrast, severity of prematurity (GA, BW) correlated with foveal area (p<0.005), depth (p≤0.001) and slope (p<0.01) although CFT (p=0.007) and pRT (p<0.001) correlated with GA but not BW.Conclusions: Foveal width is independent of GA and BW with potential in ROPscreening assessment using HH-OCT. Foveal morphology could be graded inprematurity during development, with possible implications for future management of preterm infants.

AB - Purpose: To investigate dynamic foveal morphology with postmenstrual age (PMA), in preterm infants with and without retinopathy of prematurity (ROP) using hand-held optical coherence tomography (HH-OCT), adjusting for gestational age (GA) and birthweight (BW).Methods: Prospective mixed cross-sectional / longitudinal observational study of 87 participants (23 to 36 weeks GA; n=30 with, n=57 without ROP) using HH-OCT images (n=278) acquired between 31 to 44 weeks PMA excluding treated ROP. Measurements included foveal width, area, depth, central foveal thickness (CFT), maximum slope and parafoveal retinal thickness (pRT) at 1000 µm nasal and temporal to the central fovea.Results: ROP was significantly correlated with only foveal width in either GA or BW adjusted statistical models. In contrast, severity of prematurity (GA, BW) correlated with foveal area (p<0.005), depth (p≤0.001) and slope (p<0.01) although CFT (p=0.007) and pRT (p<0.001) correlated with GA but not BW.Conclusions: Foveal width is independent of GA and BW with potential in ROPscreening assessment using HH-OCT. Foveal morphology could be graded inprematurity during development, with possible implications for future management of preterm infants.

KW - Foveal Morphology

KW - hand-held Optical Coherence Tomography

KW - prematurity

KW - preterm infant

KW - retinopathy of prematurity

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DO - 10.1097/IAE.0000000000002622

M3 - Article

JO - Retina

JF - Retina

SN - 0275-004X

ER -