Potentiation of the response to chemotherapy in patients with breast cancer by dietary supplementation with L-arginine: Results of a randomised controlled trial

Steven D. Heys*, Keith Ogston, Ian Miller, Andrew W. Hutcheon, Leslie G. Walker, Tarun K. Sarker, John Dewar, Antoine K. Ah-See, Oleg Eremin

*Corresponding author for this work

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Patients with large primary breast cancers are being treated with neo- adjuvant chemotherapy. Studies in animals have shown that responses to chemotherapy can be increased by dietary manipulation of tumour cell metabolism. Also dietary supplementation with the amino acid L-arginine, resulted in an increase in turnout metabolic activity expression of the nuclear activation antigen, Ki67, in patients with breast cancer. Therefore, we have carried out a randomised, double blind, placebo controlled trial to determine if L-arginine supplementation is beneficial in patients with breast cancer, undergoing neo-adjuvant chemotherapy. 96 patients were randomised to receive L-arginine (30 g/day) for three days (n=48) or placebo (n=48) prior to undergoing chemotherapy (doxorubicin, cyclophosphamide, vincristine, prednisolone), 6 pulses at 21-day intervals. Clinical and pathological responses were assessed in both groups of patients following completion of chemotherapy. The clinical response rate was 77% (23% complete and 54% partial responses) in the L-arginine treated group, compared with 71% (15% complete and 56% partial) in the placebo group of patients (p=ns). However, in patients with tumours less than 6 cm in initial diameter, there was a significant increase in the better histopathological responses in the L- arginine group, when compared with the placebo group of patients (88% vs 52%, p=0.04). This may have important implications for clinical practice.

Original languageEnglish
Pages (from-to)221-225
Number of pages5
JournalInternational Journal of Oncology
Volume12
Issue number1
Publication statusPublished - 1 Jan 1998

Keywords

  • Breast cancer
  • Chemotherapy
  • L-arginine
  • Randomised controlled trial

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    Heys, S. D., Ogston, K., Miller, I., Hutcheon, A. W., Walker, L. G., Sarker, T. K., Dewar, J., Ah-See, A. K., & Eremin, O. (1998). Potentiation of the response to chemotherapy in patients with breast cancer by dietary supplementation with L-arginine: Results of a randomised controlled trial. International Journal of Oncology, 12(1), 221-225.