Pre-clinical modeling of breast cancer: Which model to choose?

Claire Nash; Valerie Speirs

doi:10.1007/978-1-4614-5647-6_9

Pre-clinical modeling of breast cancer: Which model to choose?

Claire Nash, Valerie Speirs^*

^*Corresponding author for this work

University of Leeds

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Citation (Scopus)

Abstract

Breast cancer is a highly heterogeneous disease with several morphological and genetic sub-types identified in recent decades. The recognition that the breast microenvironment plays an active role in dictating mammary epithelial cell behavior calls for a need for models which better define the in vivo environment to use in breast research. However, given that breast cancer is so diverse one model is unlikely to recapitulate all aspects of breast cancer progression. Here we discuss the advantages and disadvantages of a variety of models available to researchers and outline their suitability to specific applications of breast cancer research.

Original language	English
Title of host publication	Breast Cancer Metastasis and Drug Resistance
Subtitle of host publication	Progress and Prospects
Publisher	Springer New York
Chapter	9
Pages	161-175
Number of pages	15
ISBN (Electronic)	9781461456476
ISBN (Print)	1461456460, 9781461456469
DOIs	https://doi.org/10.1007/978-1-4614-5647-6_9
Publication status	Published - 1 Aug 2012
Externally published	Yes

Keywords

Breast cancer
Cell lines
Extracellular matrix (ECM)
Genetically Engineered Mice (GEM)
Matrigel™
Mouse
Syngeneic mouse model
Three-dimensional (3D) in vitro models
Tissue slice
Tumorigenesis
Two-dimensional (2D) in vitro models
Xenografts

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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title = "Pre-clinical modeling of breast cancer: Which model to choose?",

abstract = "Breast cancer is a highly heterogeneous disease with several morphological and genetic sub-types identified in recent decades. The recognition that the breast microenvironment plays an active role in dictating mammary epithelial cell behavior calls for a need for models which better define the in vivo environment to use in breast research. However, given that breast cancer is so diverse one model is unlikely to recapitulate all aspects of breast cancer progression. Here we discuss the advantages and disadvantages of a variety of models available to researchers and outline their suitability to specific applications of breast cancer research.",

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author = "Claire Nash and Valerie Speirs",

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doi = "10.1007/978-1-4614-5647-6_9",

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AU - Speirs, Valerie

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N2 - Breast cancer is a highly heterogeneous disease with several morphological and genetic sub-types identified in recent decades. The recognition that the breast microenvironment plays an active role in dictating mammary epithelial cell behavior calls for a need for models which better define the in vivo environment to use in breast research. However, given that breast cancer is so diverse one model is unlikely to recapitulate all aspects of breast cancer progression. Here we discuss the advantages and disadvantages of a variety of models available to researchers and outline their suitability to specific applications of breast cancer research.

AB - Breast cancer is a highly heterogeneous disease with several morphological and genetic sub-types identified in recent decades. The recognition that the breast microenvironment plays an active role in dictating mammary epithelial cell behavior calls for a need for models which better define the in vivo environment to use in breast research. However, given that breast cancer is so diverse one model is unlikely to recapitulate all aspects of breast cancer progression. Here we discuss the advantages and disadvantages of a variety of models available to researchers and outline their suitability to specific applications of breast cancer research.

KW - Breast cancer

KW - Cell lines

KW - Extracellular matrix (ECM)

KW - Genetically Engineered Mice (GEM)

KW - Matrigel™

KW - Mouse

KW - Syngeneic mouse model

KW - Three-dimensional (3D) in vitro models

KW - Tissue slice

KW - Tumorigenesis

KW - Two-dimensional (2D) in vitro models

KW - Xenografts

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DO - 10.1007/978-1-4614-5647-6_9

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SN - 1461456460

SN - 9781461456469

SP - 161

EP - 175

BT - Breast Cancer Metastasis and Drug Resistance

PB - Springer New York

ER -

Pre-clinical modeling of breast cancer: Which model to choose?

Abstract

Keywords

UN SDGs

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