Pre-clinical modeling of breast cancer: Which model to choose?

Claire Nash, Valerie Speirs*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Breast cancer is a highly heterogeneous disease with several morphological and genetic sub-types identified in recent decades. The recognition that the breast microenvironment plays an active role in dictating mammary epithelial cell behavior calls for a need for models which better define the in vivo environment to use in breast research. However, given that breast cancer is so diverse one model is unlikely to recapitulate all aspects of breast cancer progression. Here we discuss the advantages and disadvantages of a variety of models available to researchers and outline their suitability to specific applications of breast cancer research.

Original languageEnglish
Title of host publicationBreast Cancer Metastasis and Drug Resistance
Subtitle of host publicationProgress and Prospects
PublisherSpringer New York
Chapter9
Pages161-175
Number of pages15
ISBN (Electronic)9781461456476
ISBN (Print)1461456460, 9781461456469
DOIs
Publication statusPublished - 1 Aug 2012

Keywords

  • Breast cancer
  • Cell lines
  • Extracellular matrix (ECM)
  • Genetically Engineered Mice (GEM)
  • Matrigel™
  • Mouse
  • Syngeneic mouse model
  • Three-dimensional (3D) in vitro models
  • Tissue slice
  • Tumorigenesis
  • Two-dimensional (2D) in vitro models
  • Xenografts

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