Preconception Lifestyle and Cardiovascular Health in the Offspring of Overweight and Obese Women

Tessa M. van Elten; Cornelieke van de Beek; Anouk Geelen; Reinoud J.B.J. Gemke; Henk Groen; Annemieke Hoek; Ben Willem Mol; Mireille N.M. van Poppel; Tessa J. Roseboom

doi:10.3390/nu11102446

Preconception Lifestyle and Cardiovascular Health in the Offspring of Overweight and Obese Women

Tessa M. van Elten^*, Cornelieke van de Beek, Anouk Geelen, Reinoud J.B.J. Gemke, Henk Groen, Annemieke Hoek, Ben Willem Mol, Mireille N.M. van Poppel, Tessa J. Roseboom

^*Corresponding author for this work

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Abstract

Women’s lifestyle has important implications for the development and health of their offspring. Yet little is known about the association between women’s preconception dietary intake and physical activity with cardiovascular health of the offspring. We therefore examined this association in a group of Dutch women with overweight or obesity (BMI ≥ 29 kg/m²) and infertility, who participated in a 6-month randomized preconception lifestyle intervention trial, and their offspring (n = 46). Preconception dietary intake and physical activity were assessed during the 6-month intervention using a food frequency questionnaire and the Short QUestionnaire to ASsess Health-enhancing physical activity (SQUASH), respectively. Offspring cardiovascular health (i.e., BMI, waist:height ratio, systolic and diastolic blood pressure, fat and fat free mass, and pulse wave velocity) was measured at age 3–6 years. Multivariable linear regression analyses were used to examine the associations between preconception lifestyle and offspring cardiovascular health. Higher preconception vegetable intake (per 10 g/day) was associated with lower offspring diastolic blood pressure (Z-score: −0.05 (−0.08; −0.01); p = 0.007) and higher preconception fruit intake (per 10 g/day) was associated with lower offspring pulse wave velocity (−0.05 m/s (−0.10; −0.01); p = 0.03). Against our expectations, higher preconception intake of sugary drinks was associated with a higher offspring fat free mass (0.54 kg (0.01; 1.07); p = 0.045). To conclude, preconception dietary intake is associated with offspring health.

Original language	English
Article number	2446
Number of pages	12
Journal	Nutrients
Volume	11
Issue number	10
DOIs	https://doi.org/10.3390/nu11102446
Publication status	Published - 14 Oct 2019

Bibliographical note

Funding:

The LIFEstyle study was funded by ZonMw, the Dutch Organization for Health Research and Development, grant number: 50-50110-96-518. The follow-up of the LIFEstyle trial was funded by grants from the Dutch Heart Foundation (2013T085) and the European Commission (Horizon2020 project 633595 DynaHealth). None of these organizations had a role in data collection, analysis, interpretation of data, or writing the report.

Acknowledgments:

We thank all participants of the WOMB project, all participating hospitals and their staff and the members of the Dutch Consortium (www.studies-obsgyn.nl) for their hard work and dedication. Furthermore,we thank all members of the WOMB project who contributed to the follow-up study.

Data Availability Statement

Supplementary Materials:

The following are available online at http://www.mdpi.com/2072-6643/11/10/2446/s1, Table S1: Women and offspring characteristics of the participants (n = 46) vs. the non-participants (n = 259), Table S2: Linear regression analysis of the preconception food score (0–5 points; the higher the more healthy) and offspring cardiovascular health at age 3–6 years.

Keywords

Offspring anthropometry
Offspring blood pressure
Offspring pulse wave velocity
Preconception dietary intake
Preconception physical activity

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Preconception Lifestyle and Cardiovascular Health in the Offspring of Overweight and Obese Women",

abstract = "Women{\textquoteright}s lifestyle has important implications for the development and health of their offspring. Yet little is known about the association between women{\textquoteright}s preconception dietary intake and physical activity with cardiovascular health of the offspring. We therefore examined this association in a group of Dutch women with overweight or obesity (BMI ≥ 29 kg/m2) and infertility, who participated in a 6-month randomized preconception lifestyle intervention trial, and their offspring (n = 46). Preconception dietary intake and physical activity were assessed during the 6-month intervention using a food frequency questionnaire and the Short QUestionnaire to ASsess Health-enhancing physical activity (SQUASH), respectively. Offspring cardiovascular health (i.e., BMI, waist:height ratio, systolic and diastolic blood pressure, fat and fat free mass, and pulse wave velocity) was measured at age 3–6 years. Multivariable linear regression analyses were used to examine the associations between preconception lifestyle and offspring cardiovascular health. Higher preconception vegetable intake (per 10 g/day) was associated with lower offspring diastolic blood pressure (Z-score: −0.05 (−0.08; −0.01); p = 0.007) and higher preconception fruit intake (per 10 g/day) was associated with lower offspring pulse wave velocity (−0.05 m/s (−0.10; −0.01); p = 0.03). Against our expectations, higher preconception intake of sugary drinks was associated with a higher offspring fat free mass (0.54 kg (0.01; 1.07); p = 0.045). To conclude, preconception dietary intake is associated with offspring health.",

keywords = "Offspring anthropometry, Offspring blood pressure, Offspring pulse wave velocity, Preconception dietary intake, Preconception physical activity",

author = "{van Elten}, {Tessa M.} and {van de Beek}, Cornelieke and Anouk Geelen and Gemke, {Reinoud J.B.J.} and Henk Groen and Annemieke Hoek and Mol, {Ben Willem} and {van Poppel}, {Mireille N.M.} and Roseboom, {Tessa J.}",

note = "Funding: The LIFEstyle study was funded by ZonMw, the Dutch Organization for Health Research and Development, grant number: 50-50110-96-518. The follow-up of the LIFEstyle trial was funded by grants from the Dutch Heart Foundation (2013T085) and the European Commission (Horizon2020 project 633595 DynaHealth). None of these organizations had a role in data collection, analysis, interpretation of data, or writing the report. Acknowledgments: We thank all participants of the WOMB project, all participating hospitals and their staff and the members of the Dutch Consortium (www.studies-obsgyn.nl) for their hard work and dedication. Furthermore,we thank all members of the WOMB project who contributed to the follow-up study.",

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AU - van Elten, Tessa M.

AU - van de Beek, Cornelieke

AU - Geelen, Anouk

AU - Gemke, Reinoud J.B.J.

AU - Groen, Henk

AU - Hoek, Annemieke

AU - Mol, Ben Willem

AU - van Poppel, Mireille N.M.

AU - Roseboom, Tessa J.

N1 - Funding: The LIFEstyle study was funded by ZonMw, the Dutch Organization for Health Research and Development, grant number: 50-50110-96-518. The follow-up of the LIFEstyle trial was funded by grants from the Dutch Heart Foundation (2013T085) and the European Commission (Horizon2020 project 633595 DynaHealth). None of these organizations had a role in data collection, analysis, interpretation of data, or writing the report. Acknowledgments: We thank all participants of the WOMB project, all participating hospitals and their staff and the members of the Dutch Consortium (www.studies-obsgyn.nl) for their hard work and dedication. Furthermore,we thank all members of the WOMB project who contributed to the follow-up study.

PY - 2019/10/14

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N2 - Women’s lifestyle has important implications for the development and health of their offspring. Yet little is known about the association between women’s preconception dietary intake and physical activity with cardiovascular health of the offspring. We therefore examined this association in a group of Dutch women with overweight or obesity (BMI ≥ 29 kg/m2) and infertility, who participated in a 6-month randomized preconception lifestyle intervention trial, and their offspring (n = 46). Preconception dietary intake and physical activity were assessed during the 6-month intervention using a food frequency questionnaire and the Short QUestionnaire to ASsess Health-enhancing physical activity (SQUASH), respectively. Offspring cardiovascular health (i.e., BMI, waist:height ratio, systolic and diastolic blood pressure, fat and fat free mass, and pulse wave velocity) was measured at age 3–6 years. Multivariable linear regression analyses were used to examine the associations between preconception lifestyle and offspring cardiovascular health. Higher preconception vegetable intake (per 10 g/day) was associated with lower offspring diastolic blood pressure (Z-score: −0.05 (−0.08; −0.01); p = 0.007) and higher preconception fruit intake (per 10 g/day) was associated with lower offspring pulse wave velocity (−0.05 m/s (−0.10; −0.01); p = 0.03). Against our expectations, higher preconception intake of sugary drinks was associated with a higher offspring fat free mass (0.54 kg (0.01; 1.07); p = 0.045). To conclude, preconception dietary intake is associated with offspring health.

AB - Women’s lifestyle has important implications for the development and health of their offspring. Yet little is known about the association between women’s preconception dietary intake and physical activity with cardiovascular health of the offspring. We therefore examined this association in a group of Dutch women with overweight or obesity (BMI ≥ 29 kg/m2) and infertility, who participated in a 6-month randomized preconception lifestyle intervention trial, and their offspring (n = 46). Preconception dietary intake and physical activity were assessed during the 6-month intervention using a food frequency questionnaire and the Short QUestionnaire to ASsess Health-enhancing physical activity (SQUASH), respectively. Offspring cardiovascular health (i.e., BMI, waist:height ratio, systolic and diastolic blood pressure, fat and fat free mass, and pulse wave velocity) was measured at age 3–6 years. Multivariable linear regression analyses were used to examine the associations between preconception lifestyle and offspring cardiovascular health. Higher preconception vegetable intake (per 10 g/day) was associated with lower offspring diastolic blood pressure (Z-score: −0.05 (−0.08; −0.01); p = 0.007) and higher preconception fruit intake (per 10 g/day) was associated with lower offspring pulse wave velocity (−0.05 m/s (−0.10; −0.01); p = 0.03). Against our expectations, higher preconception intake of sugary drinks was associated with a higher offspring fat free mass (0.54 kg (0.01; 1.07); p = 0.045). To conclude, preconception dietary intake is associated with offspring health.

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KW - Preconception dietary intake

KW - Preconception physical activity

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Preconception Lifestyle and Cardiovascular Health in the Offspring of Overweight and Obese Women

Abstract

Bibliographical note

Data Availability Statement

Keywords

UN SDGs

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