Predation risk modulates diet-induced obesity in male C57BL/6 mice

Rita I Monarca, Maria da Luz Mathias, DeHua Wang, John R Speakman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

OBJECTIVE: In this study, the behavioral and physiological changes induced by experimentally varying the risk of predation in male mice fed a high-fat diet were examined. In particular, the study aimed to assess whether the risk of being predated modulates the body weight gain, providing an ecological context for the obesity resistance observed in many species of small mammals.

METHODS: Body weight, food intake, physical activity, and core body temperature of 35 male C57BL/6 mice were monitored for 20 days, while feeding a high-fat diet. A third of the animals were exposed to elevated risk of predation through exposure to the sounds of nocturnal predatory birds, and these were compared to animals exposed to a neutral noise or silence.

RESULTS: Male mice exposed to predation risk had significantly lower weight gain than the neutral or silent groups. Reduced food intake and increased physical activity were the main proximal factors explaining this effect. The risk of predation also induced changes in boldness.

CONCLUSIONS: This study provides evidence supporting the role of predation risk on body weight gain of small mammals.

Original languageEnglish
Pages (from-to)2059-2065
Number of pages7
JournalObesity
Volume23
Issue number10
Early online date31 Aug 2015
DOIs
Publication statusPublished - Oct 2015

Fingerprint

Inbred C57BL Mouse
Obesity
Diet
Weight Gain
Body Weight
High Fat Diet
Mammals
Eating
Body Temperature
Birds
Noise

Keywords

  • Animals
  • Diet, High-Fat
  • Eating
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Obesity
  • Predatory Behavior
  • Weight Gain

Cite this

Predation risk modulates diet-induced obesity in male C57BL/6 mice. / Monarca, Rita I; da Luz Mathias, Maria; Wang, DeHua; Speakman, John R.

In: Obesity, Vol. 23, No. 10, 10.2015, p. 2059-2065.

Research output: Contribution to journalArticle

Monarca, RI, da Luz Mathias, M, Wang, D & Speakman, JR 2015, 'Predation risk modulates diet-induced obesity in male C57BL/6 mice' Obesity, vol. 23, no. 10, pp. 2059-2065. https://doi.org/10.1002/oby.21193
Monarca, Rita I ; da Luz Mathias, Maria ; Wang, DeHua ; Speakman, John R. / Predation risk modulates diet-induced obesity in male C57BL/6 mice. In: Obesity. 2015 ; Vol. 23, No. 10. pp. 2059-2065.
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abstract = "OBJECTIVE: In this study, the behavioral and physiological changes induced by experimentally varying the risk of predation in male mice fed a high-fat diet were examined. In particular, the study aimed to assess whether the risk of being predated modulates the body weight gain, providing an ecological context for the obesity resistance observed in many species of small mammals.METHODS: Body weight, food intake, physical activity, and core body temperature of 35 male C57BL/6 mice were monitored for 20 days, while feeding a high-fat diet. A third of the animals were exposed to elevated risk of predation through exposure to the sounds of nocturnal predatory birds, and these were compared to animals exposed to a neutral noise or silence.RESULTS: Male mice exposed to predation risk had significantly lower weight gain than the neutral or silent groups. Reduced food intake and increased physical activity were the main proximal factors explaining this effect. The risk of predation also induced changes in boldness.CONCLUSIONS: This study provides evidence supporting the role of predation risk on body weight gain of small mammals.",
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note = "Funding agencies: This study was funded by the strategic priority research program of the Chinese Academy of Sciences (XDB13030000), National Funds through the Portuguese Science Foundation (FCT) within project PEst-C/MAR/LA0017/2013, and PhD fellowship (SFRH/BD/47333/2008), by European Funds through COMPETE. JRS was supported by the 1000 talents program of the Chinese government.",
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AU - Speakman, John R

N1 - Funding agencies: This study was funded by the strategic priority research program of the Chinese Academy of Sciences (XDB13030000), National Funds through the Portuguese Science Foundation (FCT) within project PEst-C/MAR/LA0017/2013, and PhD fellowship (SFRH/BD/47333/2008), by European Funds through COMPETE. JRS was supported by the 1000 talents program of the Chinese government.

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