Predicted impact of extending the screening interval for diabetic retinopathy

the Scottish Diabetic Retinopathy Screening programme

H C Looker, S O Nyangoma, D T Cromie, J A Olson, G P Leese, S Philip, M W Black, J Doig, N Lee, A Briggs, E J Hothersall, A D Morris, R S Lindsay, J A McKnight, D W M Pearson, N A Sattar, S H Wild, P McKeigue, H M Colhoun, Scottish Diabetes Research Network (SDRN) Epidemiology group & 1 others Scottish Diabetic Retinopathy Collaborative

Research output: Contribution to journalArticle

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Abstract

Aims/hypothesis
The aim of our study was to identify subgroups of patients attending the Scottish Diabetic Retinopathy Screening (DRS) programme who might safely move from annual to two yearly retinopathy screening.
Methods
This was a retrospective cohort study of screening data from the DRS programme collected between 2005 and 2011 for people aged ≥12 years with type 1 or type 2 diabetes in Scotland. We used hidden Markov models to calculate the probabilities of transitions to referable diabetic retinopathy (referable background or proliferative retinopathy) or referable maculopathy.
Results
The study included 155,114 individuals with no referable diabetic retinopathy or maculopathy at their first DRS examination and with one or more further DRS examinations. There were 11,275 incident cases of referable diabetic eye disease (9,204 referable maculopathy, 2,071 referable background or proliferative retinopathy). The observed transitions to referable background or proliferative retinopathy were lower for people with no visible retinopathy vs mild background retinopathy at their prior examination (respectively, 1.2% vs 8.1% for type 1 diabetes and 0.6% vs 5.1% for type 2 diabetes). The lowest probability for transitioning to referable background or proliferative retinopathy was among people with two consecutive screens showing no visible retinopathy, where the probability was <0.3% for type 1 and <0.2% for type 2 diabetes at 2 years.
Conclusions/interpretation
Transition rates to referable diabetic eye disease were lowest among people with type 2 diabetes and two consecutive screens showing no visible retinopathy. If such people had been offered two yearly screening the DRS service would have needed to screen 40% fewer people in 2009.
Original languageEnglish
Pages (from-to)1716-1725
Number of pages10
JournalDiabetologia
Volume56
Issue number8
Early online date21 May 2013
DOIs
Publication statusPublished - Aug 2013

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Diabetic Retinopathy
Type 2 Diabetes Mellitus
Eye Diseases
Scotland
Type 1 Diabetes Mellitus
Cohort Studies
Retrospective Studies

Keywords

  • diabetes
  • diabetic retinopathy
  • maculopathy
  • retinal screening
  • screening intervals

Cite this

Predicted impact of extending the screening interval for diabetic retinopathy : the Scottish Diabetic Retinopathy Screening programme. / Looker, H C; Nyangoma, S O; Cromie, D T; Olson, J A; Leese, G P; Philip, S; Black, M W; Doig, J; Lee, N; Briggs, A; Hothersall, E J; Morris, A D; Lindsay, R S; McKnight, J A; Pearson, D W M; Sattar, N A; Wild, S H; McKeigue, P; Colhoun, H M; Scottish Diabetes Research Network (SDRN) Epidemiology group; Scottish Diabetic Retinopathy Collaborative.

In: Diabetologia, Vol. 56, No. 8, 08.2013, p. 1716-1725.

Research output: Contribution to journalArticle

Looker, HC, Nyangoma, SO, Cromie, DT, Olson, JA, Leese, GP, Philip, S, Black, MW, Doig, J, Lee, N, Briggs, A, Hothersall, EJ, Morris, AD, Lindsay, RS, McKnight, JA, Pearson, DWM, Sattar, NA, Wild, SH, McKeigue, P, Colhoun, HM, Scottish Diabetes Research Network (SDRN) Epidemiology group & Scottish Diabetic Retinopathy Collaborative 2013, 'Predicted impact of extending the screening interval for diabetic retinopathy: the Scottish Diabetic Retinopathy Screening programme', Diabetologia, vol. 56, no. 8, pp. 1716-1725. https://doi.org/10.1007/s00125-013-2928-7
Looker, H C ; Nyangoma, S O ; Cromie, D T ; Olson, J A ; Leese, G P ; Philip, S ; Black, M W ; Doig, J ; Lee, N ; Briggs, A ; Hothersall, E J ; Morris, A D ; Lindsay, R S ; McKnight, J A ; Pearson, D W M ; Sattar, N A ; Wild, S H ; McKeigue, P ; Colhoun, H M ; Scottish Diabetes Research Network (SDRN) Epidemiology group ; Scottish Diabetic Retinopathy Collaborative. / Predicted impact of extending the screening interval for diabetic retinopathy : the Scottish Diabetic Retinopathy Screening programme. In: Diabetologia. 2013 ; Vol. 56, No. 8. pp. 1716-1725.
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abstract = "Aims/hypothesisThe aim of our study was to identify subgroups of patients attending the Scottish Diabetic Retinopathy Screening (DRS) programme who might safely move from annual to two yearly retinopathy screening.MethodsThis was a retrospective cohort study of screening data from the DRS programme collected between 2005 and 2011 for people aged ≥12 years with type 1 or type 2 diabetes in Scotland. We used hidden Markov models to calculate the probabilities of transitions to referable diabetic retinopathy (referable background or proliferative retinopathy) or referable maculopathy.ResultsThe study included 155,114 individuals with no referable diabetic retinopathy or maculopathy at their first DRS examination and with one or more further DRS examinations. There were 11,275 incident cases of referable diabetic eye disease (9,204 referable maculopathy, 2,071 referable background or proliferative retinopathy). The observed transitions to referable background or proliferative retinopathy were lower for people with no visible retinopathy vs mild background retinopathy at their prior examination (respectively, 1.2{\%} vs 8.1{\%} for type 1 diabetes and 0.6{\%} vs 5.1{\%} for type 2 diabetes). The lowest probability for transitioning to referable background or proliferative retinopathy was among people with two consecutive screens showing no visible retinopathy, where the probability was <0.3{\%} for type 1 and <0.2{\%} for type 2 diabetes at 2 years.Conclusions/interpretationTransition rates to referable diabetic eye disease were lowest among people with type 2 diabetes and two consecutive screens showing no visible retinopathy. If such people had been offered two yearly screening the DRS service would have needed to screen 40{\%} fewer people in 2009.",
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T1 - Predicted impact of extending the screening interval for diabetic retinopathy

T2 - the Scottish Diabetic Retinopathy Screening programme

AU - Looker, H C

AU - Nyangoma, S O

AU - Cromie, D T

AU - Olson, J A

AU - Leese, G P

AU - Philip, S

AU - Black, M W

AU - Doig, J

AU - Lee, N

AU - Briggs, A

AU - Hothersall, E J

AU - Morris, A D

AU - Lindsay, R S

AU - McKnight, J A

AU - Pearson, D W M

AU - Sattar, N A

AU - Wild, S H

AU - McKeigue, P

AU - Colhoun, H M

AU - Scottish Diabetes Research Network (SDRN) Epidemiology group

AU - Scottish Diabetic Retinopathy Collaborative

PY - 2013/8

Y1 - 2013/8

N2 - Aims/hypothesisThe aim of our study was to identify subgroups of patients attending the Scottish Diabetic Retinopathy Screening (DRS) programme who might safely move from annual to two yearly retinopathy screening.MethodsThis was a retrospective cohort study of screening data from the DRS programme collected between 2005 and 2011 for people aged ≥12 years with type 1 or type 2 diabetes in Scotland. We used hidden Markov models to calculate the probabilities of transitions to referable diabetic retinopathy (referable background or proliferative retinopathy) or referable maculopathy.ResultsThe study included 155,114 individuals with no referable diabetic retinopathy or maculopathy at their first DRS examination and with one or more further DRS examinations. There were 11,275 incident cases of referable diabetic eye disease (9,204 referable maculopathy, 2,071 referable background or proliferative retinopathy). The observed transitions to referable background or proliferative retinopathy were lower for people with no visible retinopathy vs mild background retinopathy at their prior examination (respectively, 1.2% vs 8.1% for type 1 diabetes and 0.6% vs 5.1% for type 2 diabetes). The lowest probability for transitioning to referable background or proliferative retinopathy was among people with two consecutive screens showing no visible retinopathy, where the probability was <0.3% for type 1 and <0.2% for type 2 diabetes at 2 years.Conclusions/interpretationTransition rates to referable diabetic eye disease were lowest among people with type 2 diabetes and two consecutive screens showing no visible retinopathy. If such people had been offered two yearly screening the DRS service would have needed to screen 40% fewer people in 2009.

AB - Aims/hypothesisThe aim of our study was to identify subgroups of patients attending the Scottish Diabetic Retinopathy Screening (DRS) programme who might safely move from annual to two yearly retinopathy screening.MethodsThis was a retrospective cohort study of screening data from the DRS programme collected between 2005 and 2011 for people aged ≥12 years with type 1 or type 2 diabetes in Scotland. We used hidden Markov models to calculate the probabilities of transitions to referable diabetic retinopathy (referable background or proliferative retinopathy) or referable maculopathy.ResultsThe study included 155,114 individuals with no referable diabetic retinopathy or maculopathy at their first DRS examination and with one or more further DRS examinations. There were 11,275 incident cases of referable diabetic eye disease (9,204 referable maculopathy, 2,071 referable background or proliferative retinopathy). The observed transitions to referable background or proliferative retinopathy were lower for people with no visible retinopathy vs mild background retinopathy at their prior examination (respectively, 1.2% vs 8.1% for type 1 diabetes and 0.6% vs 5.1% for type 2 diabetes). The lowest probability for transitioning to referable background or proliferative retinopathy was among people with two consecutive screens showing no visible retinopathy, where the probability was <0.3% for type 1 and <0.2% for type 2 diabetes at 2 years.Conclusions/interpretationTransition rates to referable diabetic eye disease were lowest among people with type 2 diabetes and two consecutive screens showing no visible retinopathy. If such people had been offered two yearly screening the DRS service would have needed to screen 40% fewer people in 2009.

KW - diabetes

KW - diabetic retinopathy

KW - maculopathy

KW - retinal screening

KW - screening intervals

U2 - 10.1007/s00125-013-2928-7

DO - 10.1007/s00125-013-2928-7

M3 - Article

VL - 56

SP - 1716

EP - 1725

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 8

ER -