Predicting breast cancer risk: implications of a "weak" family history

Elaine Anderson, Jonathan Berg, Roger Black, Nicola Bradshaw, Joyce Campbell, Roseanne Cetnarskyj, Sarah Drummond, Rosemarie Davidson, Jacqueline Dunlop, Alison Fordyce, Barbara Gibbons, David Goudie, Helen Gregory, Kirstie Hanning, Susan Holloway, Mark Longmuir, Lorna McLeish, Vicky Murday, Zosia Miedzybrodska, Donna NicholsonPauline Pearson, Mary Porteous, Marta Reis, Sheila Slater, Karen Smith, Elizabeth Smyth, Lesley Snadden, Michael Steel, Diane Stirling, Cathy Watt, Catriona Whyte, Dorothy Young, Zosia Miedzybrodzka

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Published guidelines adopted in many countries recommend that women whose family history of breast cancer places them at a risk>or=1.7 times that of the age-matched general population, should be considered for inclusion in special surveillance programmes. However validation of risk assessment models has been called for as a matter of urgency. The databases of the four Scottish Familial Breast Cancer clinics and the Scottish Cancer Registry have been searched to identify breast cancers occurring among 1,125 women aged 40-56, with family histories placing them below the "moderate" level of genetic risk. The observed incidence over 6 years was compared with age-specific data for the Scottish population. Our findings confirm that when there are two affected relatives (one first degree) the relative risk (RR) exceeds 1.7 regardless of their ages at diagnosis. When only one (first degree) relative was affected at any age from 40 to 55, the RR does not reach 1.7 if that relative was a mother but exceeds it if the relative was a sister. The probable explanation is that sisters are more likely than mother/daughter pairs to share homozygosity for a risk allele. Surveillance programmes might therefore accommodate sisters of women affected before age 55. Evidence that "low penetrance" alleles contributing to breast cancer risk may be recessive should be taken into account in strategies for identifying them.
Original languageEnglish
Pages (from-to)361-366
Number of pages6
JournalFamilial Cancer
Volume7
Issue number4
Early online date17 Jun 2008
DOIs
Publication statusPublished - Dec 2008

Fingerprint

Breast Neoplasms
Siblings
Alleles
Mothers
Penetrance
Nuclear Family
Population
Registries
Databases
Guidelines
Incidence
Neoplasms

Keywords

  • breast cancer
  • familial
  • recessive genes
  • risk

Cite this

Anderson, E., Berg, J., Black, R., Bradshaw, N., Campbell, J., Cetnarskyj, R., ... Miedzybrodzka, Z. (2008). Predicting breast cancer risk: implications of a "weak" family history. Familial Cancer, 7(4), 361-366. https://doi.org/10.1007/s10689-008-9197-5

Predicting breast cancer risk : implications of a "weak" family history. / Anderson, Elaine; Berg, Jonathan; Black, Roger; Bradshaw, Nicola; Campbell, Joyce; Cetnarskyj, Roseanne; Drummond, Sarah; Davidson, Rosemarie; Dunlop, Jacqueline; Fordyce, Alison; Gibbons, Barbara; Goudie, David; Gregory, Helen; Hanning, Kirstie; Holloway, Susan; Longmuir, Mark; McLeish, Lorna; Murday, Vicky; Miedzybrodska, Zosia; Nicholson, Donna; Pearson, Pauline; Porteous, Mary; Reis, Marta; Slater, Sheila; Smith, Karen; Smyth, Elizabeth; Snadden, Lesley; Steel, Michael; Stirling, Diane; Watt, Cathy; Whyte, Catriona; Young, Dorothy; Miedzybrodzka, Zosia.

In: Familial Cancer, Vol. 7, No. 4, 12.2008, p. 361-366.

Research output: Contribution to journalArticle

Anderson, E, Berg, J, Black, R, Bradshaw, N, Campbell, J, Cetnarskyj, R, Drummond, S, Davidson, R, Dunlop, J, Fordyce, A, Gibbons, B, Goudie, D, Gregory, H, Hanning, K, Holloway, S, Longmuir, M, McLeish, L, Murday, V, Miedzybrodska, Z, Nicholson, D, Pearson, P, Porteous, M, Reis, M, Slater, S, Smith, K, Smyth, E, Snadden, L, Steel, M, Stirling, D, Watt, C, Whyte, C, Young, D & Miedzybrodzka, Z 2008, 'Predicting breast cancer risk: implications of a "weak" family history', Familial Cancer, vol. 7, no. 4, pp. 361-366. https://doi.org/10.1007/s10689-008-9197-5
Anderson E, Berg J, Black R, Bradshaw N, Campbell J, Cetnarskyj R et al. Predicting breast cancer risk: implications of a "weak" family history. Familial Cancer. 2008 Dec;7(4):361-366. https://doi.org/10.1007/s10689-008-9197-5
Anderson, Elaine ; Berg, Jonathan ; Black, Roger ; Bradshaw, Nicola ; Campbell, Joyce ; Cetnarskyj, Roseanne ; Drummond, Sarah ; Davidson, Rosemarie ; Dunlop, Jacqueline ; Fordyce, Alison ; Gibbons, Barbara ; Goudie, David ; Gregory, Helen ; Hanning, Kirstie ; Holloway, Susan ; Longmuir, Mark ; McLeish, Lorna ; Murday, Vicky ; Miedzybrodska, Zosia ; Nicholson, Donna ; Pearson, Pauline ; Porteous, Mary ; Reis, Marta ; Slater, Sheila ; Smith, Karen ; Smyth, Elizabeth ; Snadden, Lesley ; Steel, Michael ; Stirling, Diane ; Watt, Cathy ; Whyte, Catriona ; Young, Dorothy ; Miedzybrodzka, Zosia. / Predicting breast cancer risk : implications of a "weak" family history. In: Familial Cancer. 2008 ; Vol. 7, No. 4. pp. 361-366.
@article{8988f66894e846b7be9cafeb759a6bc1,
title = "Predicting breast cancer risk: implications of a {"}weak{"} family history",
abstract = "Published guidelines adopted in many countries recommend that women whose family history of breast cancer places them at a risk>or=1.7 times that of the age-matched general population, should be considered for inclusion in special surveillance programmes. However validation of risk assessment models has been called for as a matter of urgency. The databases of the four Scottish Familial Breast Cancer clinics and the Scottish Cancer Registry have been searched to identify breast cancers occurring among 1,125 women aged 40-56, with family histories placing them below the {"}moderate{"} level of genetic risk. The observed incidence over 6 years was compared with age-specific data for the Scottish population. Our findings confirm that when there are two affected relatives (one first degree) the relative risk (RR) exceeds 1.7 regardless of their ages at diagnosis. When only one (first degree) relative was affected at any age from 40 to 55, the RR does not reach 1.7 if that relative was a mother but exceeds it if the relative was a sister. The probable explanation is that sisters are more likely than mother/daughter pairs to share homozygosity for a risk allele. Surveillance programmes might therefore accommodate sisters of women affected before age 55. Evidence that {"}low penetrance{"} alleles contributing to breast cancer risk may be recessive should be taken into account in strategies for identifying them.",
keywords = "breast cancer, familial, recessive genes, risk",
author = "Elaine Anderson and Jonathan Berg and Roger Black and Nicola Bradshaw and Joyce Campbell and Roseanne Cetnarskyj and Sarah Drummond and Rosemarie Davidson and Jacqueline Dunlop and Alison Fordyce and Barbara Gibbons and David Goudie and Helen Gregory and Kirstie Hanning and Susan Holloway and Mark Longmuir and Lorna McLeish and Vicky Murday and Zosia Miedzybrodska and Donna Nicholson and Pauline Pearson and Mary Porteous and Marta Reis and Sheila Slater and Karen Smith and Elizabeth Smyth and Lesley Snadden and Michael Steel and Diane Stirling and Cathy Watt and Catriona Whyte and Dorothy Young and Zosia Miedzybrodzka",
year = "2008",
month = "12",
doi = "10.1007/s10689-008-9197-5",
language = "English",
volume = "7",
pages = "361--366",
journal = "Familial Cancer",
issn = "1389-9600",
publisher = "Springer Netherlands",
number = "4",

}

TY - JOUR

T1 - Predicting breast cancer risk

T2 - implications of a "weak" family history

AU - Anderson, Elaine

AU - Berg, Jonathan

AU - Black, Roger

AU - Bradshaw, Nicola

AU - Campbell, Joyce

AU - Cetnarskyj, Roseanne

AU - Drummond, Sarah

AU - Davidson, Rosemarie

AU - Dunlop, Jacqueline

AU - Fordyce, Alison

AU - Gibbons, Barbara

AU - Goudie, David

AU - Gregory, Helen

AU - Hanning, Kirstie

AU - Holloway, Susan

AU - Longmuir, Mark

AU - McLeish, Lorna

AU - Murday, Vicky

AU - Miedzybrodska, Zosia

AU - Nicholson, Donna

AU - Pearson, Pauline

AU - Porteous, Mary

AU - Reis, Marta

AU - Slater, Sheila

AU - Smith, Karen

AU - Smyth, Elizabeth

AU - Snadden, Lesley

AU - Steel, Michael

AU - Stirling, Diane

AU - Watt, Cathy

AU - Whyte, Catriona

AU - Young, Dorothy

AU - Miedzybrodzka, Zosia

PY - 2008/12

Y1 - 2008/12

N2 - Published guidelines adopted in many countries recommend that women whose family history of breast cancer places them at a risk>or=1.7 times that of the age-matched general population, should be considered for inclusion in special surveillance programmes. However validation of risk assessment models has been called for as a matter of urgency. The databases of the four Scottish Familial Breast Cancer clinics and the Scottish Cancer Registry have been searched to identify breast cancers occurring among 1,125 women aged 40-56, with family histories placing them below the "moderate" level of genetic risk. The observed incidence over 6 years was compared with age-specific data for the Scottish population. Our findings confirm that when there are two affected relatives (one first degree) the relative risk (RR) exceeds 1.7 regardless of their ages at diagnosis. When only one (first degree) relative was affected at any age from 40 to 55, the RR does not reach 1.7 if that relative was a mother but exceeds it if the relative was a sister. The probable explanation is that sisters are more likely than mother/daughter pairs to share homozygosity for a risk allele. Surveillance programmes might therefore accommodate sisters of women affected before age 55. Evidence that "low penetrance" alleles contributing to breast cancer risk may be recessive should be taken into account in strategies for identifying them.

AB - Published guidelines adopted in many countries recommend that women whose family history of breast cancer places them at a risk>or=1.7 times that of the age-matched general population, should be considered for inclusion in special surveillance programmes. However validation of risk assessment models has been called for as a matter of urgency. The databases of the four Scottish Familial Breast Cancer clinics and the Scottish Cancer Registry have been searched to identify breast cancers occurring among 1,125 women aged 40-56, with family histories placing them below the "moderate" level of genetic risk. The observed incidence over 6 years was compared with age-specific data for the Scottish population. Our findings confirm that when there are two affected relatives (one first degree) the relative risk (RR) exceeds 1.7 regardless of their ages at diagnosis. When only one (first degree) relative was affected at any age from 40 to 55, the RR does not reach 1.7 if that relative was a mother but exceeds it if the relative was a sister. The probable explanation is that sisters are more likely than mother/daughter pairs to share homozygosity for a risk allele. Surveillance programmes might therefore accommodate sisters of women affected before age 55. Evidence that "low penetrance" alleles contributing to breast cancer risk may be recessive should be taken into account in strategies for identifying them.

KW - breast cancer

KW - familial

KW - recessive genes

KW - risk

U2 - 10.1007/s10689-008-9197-5

DO - 10.1007/s10689-008-9197-5

M3 - Article

C2 - 18560993

VL - 7

SP - 361

EP - 366

JO - Familial Cancer

JF - Familial Cancer

SN - 1389-9600

IS - 4

ER -