Predicting mortality and uptake of renal replacement therapy in patients with stage 4 chronic kidney disease

Bryan Conway (Corresponding Author), Angela Webster, George Ramsay, Neal Morgan, John Neary, Caroline Whitworth, John Harty

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Background. Novel strategies are required to efficiently manage the increasing number of patients diagnosed with chronic kidney disease (CKD). We sought to identify factors predicting outcome in patients with stage 4 CKD and to determine whether low-risk patients could be managed in primary care.Methods. We performed a two-centre, retrospective cohort study including 396 patients with stage 4 CKD referred to nephrology clinics from 1998 to 2002. We utilized electronic databases to determine the incidence of renal replacement therapy (RRT) and mortality and the rate of deterioration in estimated glomerular filtration rate (eGFR) to the year end 2005.Results. This was an elderly cohort, with 71.7 of patients aged ≥65 years. The risk of surviving to require dialysis fell with increasing age (HR 0.44; 95 CI: 0.23-0.84 for those >74 years verses those <65 years), in part due to the slower rate of decline in renal function in older patients (median fall in eGFR was -2.25, -1.38 and -0.86 ml min1.73 m2year in those aged <65 years, 65-74 years and >74 years, respectively, P<0.0001). Additional independent risk factors predicting RRT included: high baseline proteinuria (HR 6.26; 95 CI: 2.74-14.23 for >3 g24 h versus <0.3 g24 h), greater early decline in renal function (HR 3.86; 95 CI: 2.34-6.38 for ≥4 mlmin1.73 m2year versus <4 mlmin1.73 m2year), low baseline eGFR (HR 2.92; 95 CI: 1.61-5.30 for 15-19 versus 25-29 mlmin1.73 m2) and low haemoglobin (HR 3.16; 95 CI: 1.64-6.08 for <10 versus >12 gdl). The 98 (24.7) patients discharged to primary care had more stable renal function than those remaining under nephrology care (median change in eGFR of +0.20 versus -1.88 ml min1.73 m 2year, P = 0.0001).Conclusions. Most patients with stage 4 CKD, in particular the elderly, die without commencing RRT. Patients at low risk of progression can be identified and discharged safely to primary care with an active management plan.

Original languageEnglish
Pages (from-to)1930-1937
Number of pages8
JournalNephrology Dialysis Transplantation
Volume24
Issue number6
Early online date30 Jan 2009
DOIs
Publication statusPublished - 1 Jun 2009

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Renal Replacement Therapy
Chronic Renal Insufficiency
Mortality
Primary Health Care
Nephrology
Glomerular Filtration Rate
Dialysis
Cohort Studies
Retrospective Studies
Databases
Kidney
Incidence

Keywords

  • Chronic kidney disease
  • Elderly
  • Progression
  • Proteinuria
  • Renal replacement therapy

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

Cite this

Predicting mortality and uptake of renal replacement therapy in patients with stage 4 chronic kidney disease. / Conway, Bryan (Corresponding Author); Webster, Angela; Ramsay, George; Morgan, Neal; Neary, John; Whitworth, Caroline; Harty, John.

In: Nephrology Dialysis Transplantation, Vol. 24, No. 6, 01.06.2009, p. 1930-1937.

Research output: Contribution to journalArticle

Conway, Bryan ; Webster, Angela ; Ramsay, George ; Morgan, Neal ; Neary, John ; Whitworth, Caroline ; Harty, John. / Predicting mortality and uptake of renal replacement therapy in patients with stage 4 chronic kidney disease. In: Nephrology Dialysis Transplantation. 2009 ; Vol. 24, No. 6. pp. 1930-1937.
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abstract = "Background. Novel strategies are required to efficiently manage the increasing number of patients diagnosed with chronic kidney disease (CKD). We sought to identify factors predicting outcome in patients with stage 4 CKD and to determine whether low-risk patients could be managed in primary care.Methods. We performed a two-centre, retrospective cohort study including 396 patients with stage 4 CKD referred to nephrology clinics from 1998 to 2002. We utilized electronic databases to determine the incidence of renal replacement therapy (RRT) and mortality and the rate of deterioration in estimated glomerular filtration rate (eGFR) to the year end 2005.Results. This was an elderly cohort, with 71.7 of patients aged ≥65 years. The risk of surviving to require dialysis fell with increasing age (HR 0.44; 95 CI: 0.23-0.84 for those >74 years verses those <65 years), in part due to the slower rate of decline in renal function in older patients (median fall in eGFR was -2.25, -1.38 and -0.86 ml min1.73 m2year in those aged <65 years, 65-74 years and >74 years, respectively, P<0.0001). Additional independent risk factors predicting RRT included: high baseline proteinuria (HR 6.26; 95 CI: 2.74-14.23 for >3 g24 h versus <0.3 g24 h), greater early decline in renal function (HR 3.86; 95 CI: 2.34-6.38 for ≥4 mlmin1.73 m2year versus <4 mlmin1.73 m2year), low baseline eGFR (HR 2.92; 95 CI: 1.61-5.30 for 15-19 versus 25-29 mlmin1.73 m2) and low haemoglobin (HR 3.16; 95 CI: 1.64-6.08 for <10 versus >12 gdl). The 98 (24.7) patients discharged to primary care had more stable renal function than those remaining under nephrology care (median change in eGFR of +0.20 versus -1.88 ml min1.73 m 2year, P = 0.0001).Conclusions. Most patients with stage 4 CKD, in particular the elderly, die without commencing RRT. Patients at low risk of progression can be identified and discharged safely to primary care with an active management plan.",
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AU - Webster, Angela

AU - Ramsay, George

AU - Morgan, Neal

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AU - Whitworth, Caroline

AU - Harty, John

N1 - Acknowledgements. We are grateful to the administrative staff of the Renal Unit at Daisy Hill Hospital, Newry, who assisted in obtaining patient outcome data and to Klavs Zarins of the Renal Unit at the Royal Infirmary Edinburgh who assisted with the database searches.

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N2 - Background. Novel strategies are required to efficiently manage the increasing number of patients diagnosed with chronic kidney disease (CKD). We sought to identify factors predicting outcome in patients with stage 4 CKD and to determine whether low-risk patients could be managed in primary care.Methods. We performed a two-centre, retrospective cohort study including 396 patients with stage 4 CKD referred to nephrology clinics from 1998 to 2002. We utilized electronic databases to determine the incidence of renal replacement therapy (RRT) and mortality and the rate of deterioration in estimated glomerular filtration rate (eGFR) to the year end 2005.Results. This was an elderly cohort, with 71.7 of patients aged ≥65 years. The risk of surviving to require dialysis fell with increasing age (HR 0.44; 95 CI: 0.23-0.84 for those >74 years verses those <65 years), in part due to the slower rate of decline in renal function in older patients (median fall in eGFR was -2.25, -1.38 and -0.86 ml min1.73 m2year in those aged <65 years, 65-74 years and >74 years, respectively, P<0.0001). Additional independent risk factors predicting RRT included: high baseline proteinuria (HR 6.26; 95 CI: 2.74-14.23 for >3 g24 h versus <0.3 g24 h), greater early decline in renal function (HR 3.86; 95 CI: 2.34-6.38 for ≥4 mlmin1.73 m2year versus <4 mlmin1.73 m2year), low baseline eGFR (HR 2.92; 95 CI: 1.61-5.30 for 15-19 versus 25-29 mlmin1.73 m2) and low haemoglobin (HR 3.16; 95 CI: 1.64-6.08 for <10 versus >12 gdl). The 98 (24.7) patients discharged to primary care had more stable renal function than those remaining under nephrology care (median change in eGFR of +0.20 versus -1.88 ml min1.73 m 2year, P = 0.0001).Conclusions. Most patients with stage 4 CKD, in particular the elderly, die without commencing RRT. Patients at low risk of progression can be identified and discharged safely to primary care with an active management plan.

AB - Background. Novel strategies are required to efficiently manage the increasing number of patients diagnosed with chronic kidney disease (CKD). We sought to identify factors predicting outcome in patients with stage 4 CKD and to determine whether low-risk patients could be managed in primary care.Methods. We performed a two-centre, retrospective cohort study including 396 patients with stage 4 CKD referred to nephrology clinics from 1998 to 2002. We utilized electronic databases to determine the incidence of renal replacement therapy (RRT) and mortality and the rate of deterioration in estimated glomerular filtration rate (eGFR) to the year end 2005.Results. This was an elderly cohort, with 71.7 of patients aged ≥65 years. The risk of surviving to require dialysis fell with increasing age (HR 0.44; 95 CI: 0.23-0.84 for those >74 years verses those <65 years), in part due to the slower rate of decline in renal function in older patients (median fall in eGFR was -2.25, -1.38 and -0.86 ml min1.73 m2year in those aged <65 years, 65-74 years and >74 years, respectively, P<0.0001). Additional independent risk factors predicting RRT included: high baseline proteinuria (HR 6.26; 95 CI: 2.74-14.23 for >3 g24 h versus <0.3 g24 h), greater early decline in renal function (HR 3.86; 95 CI: 2.34-6.38 for ≥4 mlmin1.73 m2year versus <4 mlmin1.73 m2year), low baseline eGFR (HR 2.92; 95 CI: 1.61-5.30 for 15-19 versus 25-29 mlmin1.73 m2) and low haemoglobin (HR 3.16; 95 CI: 1.64-6.08 for <10 versus >12 gdl). The 98 (24.7) patients discharged to primary care had more stable renal function than those remaining under nephrology care (median change in eGFR of +0.20 versus -1.88 ml min1.73 m 2year, P = 0.0001).Conclusions. Most patients with stage 4 CKD, in particular the elderly, die without commencing RRT. Patients at low risk of progression can be identified and discharged safely to primary care with an active management plan.

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