Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis

Gabriele Simonini, Claudia Bracaglia, Marco Cattalini, Andrea Taddio, Alice Brambilla, Cinzia De Libero, Denise Pires Marafon, Roberto Caputo, Rolando Cimaz

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

OBJECTIVE: To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment.

METHODS: A retrospective, multicenter, cohort study.

RESULTS: Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel-Cox chi-square = 24.17) and by antitumor necrosis factor-α treatment (Mantel-Cox chi-square = 6.43).

CONCLUSION: Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.

Original languageEnglish
Pages (from-to)822-826
Number of pages5
JournalJournal of Rheumatology
Volume44
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

Keywords

  • Journal Article

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    Simonini, G., Bracaglia, C., Cattalini, M., Taddio, A., Brambilla, A., De Libero, C., Pires Marafon, D., Caputo, R., & Cimaz, R. (2017). Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis. Journal of Rheumatology, 44(6), 822-826. https://doi.org/10.3899/jrheum.161336