Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis

Gabriele Simonini, Claudia Bracaglia, Marco Cattalini, Andrea Taddio, Alice Brambilla, Cinzia De Libero, Denise Pires Marafon, Roberto Caputo, Rolando Cimaz

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Abstract

OBJECTIVE: To identify clinical predictors of relapse in childhood autoimmune chronic uveitis after stopping systemic treatment.

METHODS: A retrospective, multicenter, cohort study.

RESULTS: Ninety-four children in remission, receiving no treatments and with at least a 6-month followup, were enrolled. A higher probability of maintaining remission after discontinuing treatment was shown in idiopathic compared with juvenile idiopathic arthritis uveitis (Mantel-Cox chi-square = 23.21) if inactivity had been obtained within 6 months from starting systemic treatment (Mantel-Cox chi-square = 24.17) and by antitumor necrosis factor-α treatment (Mantel-Cox chi-square = 6.43).

CONCLUSION: Type of disease, time, and type of systemic therapy to achieve inactivity predict different duration of uveitis remission after treatment withdrawal.

Original languageEnglish
Pages (from-to)822-826
Number of pages5
JournalJournal of Rheumatology
Volume44
Issue number6
DOIs
Publication statusPublished - 1 Jun 2017

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Uveitis
Recurrence
Therapeutics
Juvenile Arthritis
Multicenter Studies
Cohort Studies
Necrosis

Keywords

  • Journal Article

Cite this

Simonini, G., Bracaglia, C., Cattalini, M., Taddio, A., Brambilla, A., De Libero, C., ... Cimaz, R. (2017). Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis. Journal of Rheumatology, 44(6), 822-826. https://doi.org/10.3899/jrheum.161336

Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis. / Simonini, Gabriele; Bracaglia, Claudia; Cattalini, Marco; Taddio, Andrea; Brambilla, Alice; De Libero, Cinzia; Pires Marafon, Denise; Caputo, Roberto; Cimaz, Rolando.

In: Journal of Rheumatology, Vol. 44, No. 6, 01.06.2017, p. 822-826.

Research output: Contribution to journalArticle

Simonini, G, Bracaglia, C, Cattalini, M, Taddio, A, Brambilla, A, De Libero, C, Pires Marafon, D, Caputo, R & Cimaz, R 2017, 'Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis', Journal of Rheumatology, vol. 44, no. 6, pp. 822-826. https://doi.org/10.3899/jrheum.161336
Simonini, Gabriele ; Bracaglia, Claudia ; Cattalini, Marco ; Taddio, Andrea ; Brambilla, Alice ; De Libero, Cinzia ; Pires Marafon, Denise ; Caputo, Roberto ; Cimaz, Rolando. / Predictors of Relapse after Discontinuing Systemic Treatment in Childhood Autoimmune Chronic Uveitis. In: Journal of Rheumatology. 2017 ; Vol. 44, No. 6. pp. 822-826.
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