Preparation and characterisation of hydroxyapatite and carbonate substituted hydroxyapatite granules

N Patel, S M Best, I R Gibson, S Ke, K A Hing, W Bonfield

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Phase pure hydroxyapatite and a high purity mixed AB-type carbonate substituted hydroxyapatite (CHA) were synthesised by precipitation reactions. The CHA was produced in the absence of sodium and ammonium ions which are normally introduced into the precipitation reaction to maintain charge balance [1,2]. Both the HA and CHA filter cakes were processed into granules of three different size ranges (212-500 mum, 500 mum-1mm, 1-2mm). The granules were sintered and underwent full structural characterisation. Both sets of granules exhibited similar morphologies and were acicular in shape. The apparent density (97-98%) and the packing densities of the two sets of granules were similar (50-55%). Comparable packing densities are important for in-vivo studies since this allows direct comparison of chemical effects when the same mass of granules can be implanted into a standard volume implant site. In this study we have seen granules of HA and CHA produced which have similar physical properties with the only difference being the effect of carbonate substitution in CHA. This paper reports the production and the physical and chemical characterisation of high purity HA and CHA granules as a precursor step in the development of a suitable in-vivo model.

Original languageEnglish
Title of host publicationBIOCERAMICS
EditorsS Giannini, A Moroni
Place of PublicationZURICH-UETIKON
PublisherTrans Tech Publications Ltd
Pages710
Number of pages4
ISBN (Print)0-87849-866-4
Publication statusPublished - 2000
Event13th International Symposium on Ceramic in Medicine /Symposium on Ceramic Materials in Orthopaedic Surgery: Clinical Results in the Year 2000 - BOLOGNA
Duration: 22 Nov 200026 Nov 2000

Conference

Conference13th International Symposium on Ceramic in Medicine /Symposium on Ceramic Materials in Orthopaedic Surgery: Clinical Results in the Year 2000
CityBOLOGNA
Period22/11/0026/11/00

Keywords

  • carbonate substituted hydroxylapatite
  • granules
  • hydroxyapatite HA
  • packing density

Cite this

Patel, N., Best, S. M., Gibson, I. R., Ke, S., Hing, K. A., & Bonfield, W. (2000). Preparation and characterisation of hydroxyapatite and carbonate substituted hydroxyapatite granules. In S. Giannini, & A. Moroni (Eds.), BIOCERAMICS (pp. 710). ZURICH-UETIKON: Trans Tech Publications Ltd.

Preparation and characterisation of hydroxyapatite and carbonate substituted hydroxyapatite granules. / Patel, N ; Best, S M ; Gibson, I R ; Ke, S ; Hing, K A ; Bonfield, W .

BIOCERAMICS. ed. / S Giannini; A Moroni. ZURICH-UETIKON : Trans Tech Publications Ltd, 2000. p. 710.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Patel, N, Best, SM, Gibson, IR, Ke, S, Hing, KA & Bonfield, W 2000, Preparation and characterisation of hydroxyapatite and carbonate substituted hydroxyapatite granules. in S Giannini & A Moroni (eds), BIOCERAMICS. Trans Tech Publications Ltd, ZURICH-UETIKON, pp. 710, 13th International Symposium on Ceramic in Medicine /Symposium on Ceramic Materials in Orthopaedic Surgery: Clinical Results in the Year 2000, BOLOGNA, 22/11/00.
Patel N, Best SM, Gibson IR, Ke S, Hing KA, Bonfield W. Preparation and characterisation of hydroxyapatite and carbonate substituted hydroxyapatite granules. In Giannini S, Moroni A, editors, BIOCERAMICS. ZURICH-UETIKON: Trans Tech Publications Ltd. 2000. p. 710
Patel, N ; Best, S M ; Gibson, I R ; Ke, S ; Hing, K A ; Bonfield, W . / Preparation and characterisation of hydroxyapatite and carbonate substituted hydroxyapatite granules. BIOCERAMICS. editor / S Giannini ; A Moroni. ZURICH-UETIKON : Trans Tech Publications Ltd, 2000. pp. 710
@inproceedings{4db0ad605de14e4095267fbdb2bde5a9,
title = "Preparation and characterisation of hydroxyapatite and carbonate substituted hydroxyapatite granules",
abstract = "Phase pure hydroxyapatite and a high purity mixed AB-type carbonate substituted hydroxyapatite (CHA) were synthesised by precipitation reactions. The CHA was produced in the absence of sodium and ammonium ions which are normally introduced into the precipitation reaction to maintain charge balance [1,2]. Both the HA and CHA filter cakes were processed into granules of three different size ranges (212-500 mum, 500 mum-1mm, 1-2mm). The granules were sintered and underwent full structural characterisation. Both sets of granules exhibited similar morphologies and were acicular in shape. The apparent density (97-98{\%}) and the packing densities of the two sets of granules were similar (50-55{\%}). Comparable packing densities are important for in-vivo studies since this allows direct comparison of chemical effects when the same mass of granules can be implanted into a standard volume implant site. In this study we have seen granules of HA and CHA produced which have similar physical properties with the only difference being the effect of carbonate substitution in CHA. This paper reports the production and the physical and chemical characterisation of high purity HA and CHA granules as a precursor step in the development of a suitable in-vivo model.",
keywords = "carbonate substituted hydroxylapatite, granules, hydroxyapatite HA, packing density",
author = "N Patel and Best, {S M} and Gibson, {I R} and S Ke and Hing, {K A} and W Bonfield",
year = "2000",
language = "English",
isbn = "0-87849-866-4",
pages = "710",
editor = "S Giannini and A Moroni",
booktitle = "BIOCERAMICS",
publisher = "Trans Tech Publications Ltd",

}

TY - GEN

T1 - Preparation and characterisation of hydroxyapatite and carbonate substituted hydroxyapatite granules

AU - Patel, N

AU - Best, S M

AU - Gibson, I R

AU - Ke, S

AU - Hing, K A

AU - Bonfield, W

PY - 2000

Y1 - 2000

N2 - Phase pure hydroxyapatite and a high purity mixed AB-type carbonate substituted hydroxyapatite (CHA) were synthesised by precipitation reactions. The CHA was produced in the absence of sodium and ammonium ions which are normally introduced into the precipitation reaction to maintain charge balance [1,2]. Both the HA and CHA filter cakes were processed into granules of three different size ranges (212-500 mum, 500 mum-1mm, 1-2mm). The granules were sintered and underwent full structural characterisation. Both sets of granules exhibited similar morphologies and were acicular in shape. The apparent density (97-98%) and the packing densities of the two sets of granules were similar (50-55%). Comparable packing densities are important for in-vivo studies since this allows direct comparison of chemical effects when the same mass of granules can be implanted into a standard volume implant site. In this study we have seen granules of HA and CHA produced which have similar physical properties with the only difference being the effect of carbonate substitution in CHA. This paper reports the production and the physical and chemical characterisation of high purity HA and CHA granules as a precursor step in the development of a suitable in-vivo model.

AB - Phase pure hydroxyapatite and a high purity mixed AB-type carbonate substituted hydroxyapatite (CHA) were synthesised by precipitation reactions. The CHA was produced in the absence of sodium and ammonium ions which are normally introduced into the precipitation reaction to maintain charge balance [1,2]. Both the HA and CHA filter cakes were processed into granules of three different size ranges (212-500 mum, 500 mum-1mm, 1-2mm). The granules were sintered and underwent full structural characterisation. Both sets of granules exhibited similar morphologies and were acicular in shape. The apparent density (97-98%) and the packing densities of the two sets of granules were similar (50-55%). Comparable packing densities are important for in-vivo studies since this allows direct comparison of chemical effects when the same mass of granules can be implanted into a standard volume implant site. In this study we have seen granules of HA and CHA produced which have similar physical properties with the only difference being the effect of carbonate substitution in CHA. This paper reports the production and the physical and chemical characterisation of high purity HA and CHA granules as a precursor step in the development of a suitable in-vivo model.

KW - carbonate substituted hydroxylapatite

KW - granules

KW - hydroxyapatite HA

KW - packing density

M3 - Conference contribution

SN - 0-87849-866-4

SP - 710

BT - BIOCERAMICS

A2 - Giannini, S

A2 - Moroni, A

PB - Trans Tech Publications Ltd

CY - ZURICH-UETIKON

ER -