Preparation of osteocompatible Si(IV)-enriched chitosan-silicate hybrids

Yuki Shirosaki; Kanji Tsuru; Hirofumi Moribayashi; Satoshi Hayakawa; Yuri Nakamura; Iain R. Gibson; Akiyoshi Osaka

doi:10.2109/jcersj2.118.989

Preparation of osteocompatible Si(IV)-enriched chitosan-silicate hybrids

Yuki Shirosaki, Kanji Tsuru, Hirofumi Moribayashi, Satoshi Hayakawa, Yuri Nakamura, Iain R. Gibson, Akiyoshi Osaka

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Chitosan-gamma-glycidoxypropyltrimethoxysilane (GPTMS)-tetraethoxysilane (TEOS) hybrid membranes were prepared by the sol-gel method. The effects of Si(IV) released from them on cell proliferation and differentiation were examined in terms of cell metabolic activity and the alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. The released Si(IV) inhibited cell proliferation but promoted cell differentiation. Thus, the osteocompatibility of the chitosan hybrid membranes in the chitosan-GPTMS-TEOS system can be controlled by the amount of Si(IV) released from them when they are applied to cell culture. (C) 2010 The Ceramic Society of Japan. All rights reserved.

Original language	English
Pages (from-to)	989-992
Number of pages	4
Journal	Journal of the Ceramic Society of Japan
Volume	118
Issue number	1383
DOIs	https://doi.org/10.2109/jcersj2.118.989
Publication status	Published - Nov 2010

Keywords

Chitosan
Organic-inorganic hybrid
Si(IV) species
Cell proliferation
Osteodifferentiation
in-vitro
cells
cytocompatibility
dissolution
membrane
products
scaffold
glass

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10.2109/jcersj2.118.989

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@article{130c8854503c46cfa1a7f6f5445061ce,

title = "Preparation of osteocompatible Si(IV)-enriched chitosan-silicate hybrids",

abstract = "Chitosan-gamma-glycidoxypropyltrimethoxysilane (GPTMS)-tetraethoxysilane (TEOS) hybrid membranes were prepared by the sol-gel method. The effects of Si(IV) released from them on cell proliferation and differentiation were examined in terms of cell metabolic activity and the alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. The released Si(IV) inhibited cell proliferation but promoted cell differentiation. Thus, the osteocompatibility of the chitosan hybrid membranes in the chitosan-GPTMS-TEOS system can be controlled by the amount of Si(IV) released from them when they are applied to cell culture. (C) 2010 The Ceramic Society of Japan. All rights reserved.",

keywords = "Chitosan, Organic-inorganic hybrid, Si(IV) species, Cell proliferation, Osteodifferentiation, in-vitro, cells, cytocompatibility, dissolution, membrane, products, scaffold, glass",

author = "Yuki Shirosaki and Kanji Tsuru and Hirofumi Moribayashi and Satoshi Hayakawa and Yuri Nakamura and Gibson, {Iain R.} and Akiyoshi Osaka",

year = "2010",

month = nov,

doi = "10.2109/jcersj2.118.989",

language = "English",

volume = "118",

pages = "989--992",

journal = "Journal of the Ceramic Society of Japan",

issn = "1882-0743",

publisher = "Ceramic Society of Japan/Nippon Seramikkusu Kyokai",

number = "1383",

}

TY - JOUR

T1 - Preparation of osteocompatible Si(IV)-enriched chitosan-silicate hybrids

AU - Shirosaki, Yuki

AU - Tsuru, Kanji

AU - Moribayashi, Hirofumi

AU - Hayakawa, Satoshi

AU - Nakamura, Yuri

AU - Gibson, Iain R.

AU - Osaka, Akiyoshi

PY - 2010/11

Y1 - 2010/11

N2 - Chitosan-gamma-glycidoxypropyltrimethoxysilane (GPTMS)-tetraethoxysilane (TEOS) hybrid membranes were prepared by the sol-gel method. The effects of Si(IV) released from them on cell proliferation and differentiation were examined in terms of cell metabolic activity and the alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. The released Si(IV) inhibited cell proliferation but promoted cell differentiation. Thus, the osteocompatibility of the chitosan hybrid membranes in the chitosan-GPTMS-TEOS system can be controlled by the amount of Si(IV) released from them when they are applied to cell culture. (C) 2010 The Ceramic Society of Japan. All rights reserved.

AB - Chitosan-gamma-glycidoxypropyltrimethoxysilane (GPTMS)-tetraethoxysilane (TEOS) hybrid membranes were prepared by the sol-gel method. The effects of Si(IV) released from them on cell proliferation and differentiation were examined in terms of cell metabolic activity and the alkaline phosphatase (ALP) activity of MG63 osteoblastic cells. The amount of Si(IV) released from the hybrid membranes increased with the TEOS content. The released Si(IV) inhibited cell proliferation but promoted cell differentiation. Thus, the osteocompatibility of the chitosan hybrid membranes in the chitosan-GPTMS-TEOS system can be controlled by the amount of Si(IV) released from them when they are applied to cell culture. (C) 2010 The Ceramic Society of Japan. All rights reserved.

KW - Chitosan

KW - Organic-inorganic hybrid

KW - Si(IV) species

KW - Cell proliferation

KW - Osteodifferentiation

KW - in-vitro

KW - cells

KW - cytocompatibility

KW - dissolution

KW - membrane

KW - products

KW - scaffold

KW - glass

U2 - 10.2109/jcersj2.118.989

DO - 10.2109/jcersj2.118.989

M3 - Article

VL - 118

SP - 989

EP - 992

JO - Journal of the Ceramic Society of Japan

JF - Journal of the Ceramic Society of Japan

SN - 1882-0743

IS - 1383

ER -

Preparation of osteocompatible Si(IV)-enriched chitosan-silicate hybrids

Abstract

Keywords

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