Preterm birth, infant weight gain, and childhood asthma risk

A meta-analysis of 147,000 European children

Agnes M M Sonnenschein-van der Voort, Lidia R Arends, Johan C de Jongste, Isabella Annesi-Maesano, S Hasan Arshad, Henrique Barros, Mikel Basterrechea, Hans Bisgaard, Leda Chatzi, Eva Corpeleijn, Sofia Correia, Leone C Craig, Graham Devereux, Cristian Dogaru, Miroslav Dostal, Karel Duchen, Merete Eggesbø, C Kors van der Ent, Maria P Fantini, Francesco Forastiere & 38 others Urs Frey, Ulrike Gehring, Davide Gori, Anne C van der Gugten, Wojciech Hanke, A John Henderson, Barbara Heude, Carmen Iñiguez, Hazel M Inskip, Thomas Keil, Cecily C Kelleher, Manolis Kogevinas, Eskil Kreiner-Møller, Claudia E Kuehni, Leanne K Küpers, Kinga Lancz, Pernille S Larsen, Susanne Lau, Johnny Ludvigsson, Monique Mommers, Anne-Marie Nybo Andersen, Lubica Palkovicova, Katharine C Pike, Costanza Pizzi, Kinga Polanska, Daniela Porta, Lorenzo Richiardi, Graham Roberts, Anne Schmidt, Radim J Sram, Jordi Sunyer, Carel Thijs, Maties Torrent, Karien Viljoen, Alet H Wijga, Martine Vrijheid, Vincent W V Jaddoe, Liesbeth Duijts

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Abstract

Background
Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results.

Objectives
We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years).

Methods
First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes.

Results
Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27).

Conclusion
Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.

Original languageEnglish
Pages (from-to)1317-1329
Number of pages13
JournalJournal of Allergy and Clinical Immunology
Volume133
Issue number5
Early online date11 Feb 2014
DOIs
Publication statusPublished - May 2014

Fingerprint

Premature Birth
Birth Weight
Premature Infants
Weight Gain
Asthma
Gestational Age
Parturition
Respiratory Sounds
Odds Ratio
Low Birth Weight Infant
Meta-Analysis
Growth
Cohort Studies

Keywords

  • gestational age
  • low birth weight
  • infant growth
  • wheezing
  • asthma
  • children
  • cohort Studies
  • epidemiology

Cite this

Sonnenschein-van der Voort, A. M. M., Arends, L. R., de Jongste, J. C., Annesi-Maesano, I., Arshad, S. H., Barros, H., ... Duijts, L. (2014). Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children. Journal of Allergy and Clinical Immunology, 133(5), 1317-1329. https://doi.org/10.1016/j.jaci.2013.12.1082

Preterm birth, infant weight gain, and childhood asthma risk : A meta-analysis of 147,000 European children. / Sonnenschein-van der Voort, Agnes M M; Arends, Lidia R; de Jongste, Johan C; Annesi-Maesano, Isabella; Arshad, S Hasan; Barros, Henrique; Basterrechea, Mikel; Bisgaard, Hans; Chatzi, Leda; Corpeleijn, Eva; Correia, Sofia; Craig, Leone C; Devereux, Graham; Dogaru, Cristian; Dostal, Miroslav; Duchen, Karel; Eggesbø, Merete; van der Ent, C Kors; Fantini, Maria P; Forastiere, Francesco; Frey, Urs; Gehring, Ulrike; Gori, Davide; van der Gugten, Anne C; Hanke, Wojciech; Henderson, A John; Heude, Barbara; Iñiguez, Carmen; Inskip, Hazel M; Keil, Thomas; Kelleher, Cecily C; Kogevinas, Manolis; Kreiner-Møller, Eskil; Kuehni, Claudia E; Küpers, Leanne K; Lancz, Kinga; Larsen, Pernille S; Lau, Susanne; Ludvigsson, Johnny; Mommers, Monique; Nybo Andersen, Anne-Marie; Palkovicova, Lubica; Pike, Katharine C; Pizzi, Costanza; Polanska, Kinga; Porta, Daniela; Richiardi, Lorenzo; Roberts, Graham; Schmidt, Anne; Sram, Radim J; Sunyer, Jordi; Thijs, Carel; Torrent, Maties; Viljoen, Karien; Wijga, Alet H; Vrijheid, Martine; Jaddoe, Vincent W V; Duijts, Liesbeth.

In: Journal of Allergy and Clinical Immunology, Vol. 133, No. 5, 05.2014, p. 1317-1329.

Research output: Contribution to journalArticle

Sonnenschein-van der Voort, AMM, Arends, LR, de Jongste, JC, Annesi-Maesano, I, Arshad, SH, Barros, H, Basterrechea, M, Bisgaard, H, Chatzi, L, Corpeleijn, E, Correia, S, Craig, LC, Devereux, G, Dogaru, C, Dostal, M, Duchen, K, Eggesbø, M, van der Ent, CK, Fantini, MP, Forastiere, F, Frey, U, Gehring, U, Gori, D, van der Gugten, AC, Hanke, W, Henderson, AJ, Heude, B, Iñiguez, C, Inskip, HM, Keil, T, Kelleher, CC, Kogevinas, M, Kreiner-Møller, E, Kuehni, CE, Küpers, LK, Lancz, K, Larsen, PS, Lau, S, Ludvigsson, J, Mommers, M, Nybo Andersen, A-M, Palkovicova, L, Pike, KC, Pizzi, C, Polanska, K, Porta, D, Richiardi, L, Roberts, G, Schmidt, A, Sram, RJ, Sunyer, J, Thijs, C, Torrent, M, Viljoen, K, Wijga, AH, Vrijheid, M, Jaddoe, VWV & Duijts, L 2014, 'Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children', Journal of Allergy and Clinical Immunology, vol. 133, no. 5, pp. 1317-1329. https://doi.org/10.1016/j.jaci.2013.12.1082
Sonnenschein-van der Voort AMM, Arends LR, de Jongste JC, Annesi-Maesano I, Arshad SH, Barros H et al. Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children. Journal of Allergy and Clinical Immunology. 2014 May;133(5):1317-1329. https://doi.org/10.1016/j.jaci.2013.12.1082
Sonnenschein-van der Voort, Agnes M M ; Arends, Lidia R ; de Jongste, Johan C ; Annesi-Maesano, Isabella ; Arshad, S Hasan ; Barros, Henrique ; Basterrechea, Mikel ; Bisgaard, Hans ; Chatzi, Leda ; Corpeleijn, Eva ; Correia, Sofia ; Craig, Leone C ; Devereux, Graham ; Dogaru, Cristian ; Dostal, Miroslav ; Duchen, Karel ; Eggesbø, Merete ; van der Ent, C Kors ; Fantini, Maria P ; Forastiere, Francesco ; Frey, Urs ; Gehring, Ulrike ; Gori, Davide ; van der Gugten, Anne C ; Hanke, Wojciech ; Henderson, A John ; Heude, Barbara ; Iñiguez, Carmen ; Inskip, Hazel M ; Keil, Thomas ; Kelleher, Cecily C ; Kogevinas, Manolis ; Kreiner-Møller, Eskil ; Kuehni, Claudia E ; Küpers, Leanne K ; Lancz, Kinga ; Larsen, Pernille S ; Lau, Susanne ; Ludvigsson, Johnny ; Mommers, Monique ; Nybo Andersen, Anne-Marie ; Palkovicova, Lubica ; Pike, Katharine C ; Pizzi, Costanza ; Polanska, Kinga ; Porta, Daniela ; Richiardi, Lorenzo ; Roberts, Graham ; Schmidt, Anne ; Sram, Radim J ; Sunyer, Jordi ; Thijs, Carel ; Torrent, Maties ; Viljoen, Karien ; Wijga, Alet H ; Vrijheid, Martine ; Jaddoe, Vincent W V ; Duijts, Liesbeth. / Preterm birth, infant weight gain, and childhood asthma risk : A meta-analysis of 147,000 European children. In: Journal of Allergy and Clinical Immunology. 2014 ; Vol. 133, No. 5. pp. 1317-1329.
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title = "Preterm birth, infant weight gain, and childhood asthma risk: A meta-analysis of 147,000 European children",
abstract = "Background Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes. Results Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95{\%} CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95{\%} CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95{\%} CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95{\%} CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95{\%} CI, 1.01-1.27). Conclusion Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.",
keywords = "gestational age, low birth weight, infant growth, wheezing , asthma, children, cohort Studies, epidemiology",
author = "{Sonnenschein-van der Voort}, {Agnes M M} and Arends, {Lidia R} and {de Jongste}, {Johan C} and Isabella Annesi-Maesano and Arshad, {S Hasan} and Henrique Barros and Mikel Basterrechea and Hans Bisgaard and Leda Chatzi and Eva Corpeleijn and Sofia Correia and Craig, {Leone C} and Graham Devereux and Cristian Dogaru and Miroslav Dostal and Karel Duchen and Merete Eggesb{\o} and {van der Ent}, {C Kors} and Fantini, {Maria P} and Francesco Forastiere and Urs Frey and Ulrike Gehring and Davide Gori and {van der Gugten}, {Anne C} and Wojciech Hanke and Henderson, {A John} and Barbara Heude and Carmen I{\~n}iguez and Inskip, {Hazel M} and Thomas Keil and Kelleher, {Cecily C} and Manolis Kogevinas and Eskil Kreiner-M{\o}ller and Kuehni, {Claudia E} and K{\"u}pers, {Leanne K} and Kinga Lancz and Larsen, {Pernille S} and Susanne Lau and Johnny Ludvigsson and Monique Mommers and {Nybo Andersen}, Anne-Marie and Lubica Palkovicova and Pike, {Katharine C} and Costanza Pizzi and Kinga Polanska and Daniela Porta and Lorenzo Richiardi and Graham Roberts and Anne Schmidt and Sram, {Radim J} and Jordi Sunyer and Carel Thijs and Maties Torrent and Karien Viljoen and Wijga, {Alet H} and Martine Vrijheid and Jaddoe, {Vincent W V} and Liesbeth Duijts",
note = "Copyright {\circledC} 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.",
year = "2014",
month = "5",
doi = "10.1016/j.jaci.2013.12.1082",
language = "English",
volume = "133",
pages = "1317--1329",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby/Elsevier,",
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}

TY - JOUR

T1 - Preterm birth, infant weight gain, and childhood asthma risk

T2 - A meta-analysis of 147,000 European children

AU - Sonnenschein-van der Voort, Agnes M M

AU - Arends, Lidia R

AU - de Jongste, Johan C

AU - Annesi-Maesano, Isabella

AU - Arshad, S Hasan

AU - Barros, Henrique

AU - Basterrechea, Mikel

AU - Bisgaard, Hans

AU - Chatzi, Leda

AU - Corpeleijn, Eva

AU - Correia, Sofia

AU - Craig, Leone C

AU - Devereux, Graham

AU - Dogaru, Cristian

AU - Dostal, Miroslav

AU - Duchen, Karel

AU - Eggesbø, Merete

AU - van der Ent, C Kors

AU - Fantini, Maria P

AU - Forastiere, Francesco

AU - Frey, Urs

AU - Gehring, Ulrike

AU - Gori, Davide

AU - van der Gugten, Anne C

AU - Hanke, Wojciech

AU - Henderson, A John

AU - Heude, Barbara

AU - Iñiguez, Carmen

AU - Inskip, Hazel M

AU - Keil, Thomas

AU - Kelleher, Cecily C

AU - Kogevinas, Manolis

AU - Kreiner-Møller, Eskil

AU - Kuehni, Claudia E

AU - Küpers, Leanne K

AU - Lancz, Kinga

AU - Larsen, Pernille S

AU - Lau, Susanne

AU - Ludvigsson, Johnny

AU - Mommers, Monique

AU - Nybo Andersen, Anne-Marie

AU - Palkovicova, Lubica

AU - Pike, Katharine C

AU - Pizzi, Costanza

AU - Polanska, Kinga

AU - Porta, Daniela

AU - Richiardi, Lorenzo

AU - Roberts, Graham

AU - Schmidt, Anne

AU - Sram, Radim J

AU - Sunyer, Jordi

AU - Thijs, Carel

AU - Torrent, Maties

AU - Viljoen, Karien

AU - Wijga, Alet H

AU - Vrijheid, Martine

AU - Jaddoe, Vincent W V

AU - Duijts, Liesbeth

N1 - Copyright © 2014 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

PY - 2014/5

Y1 - 2014/5

N2 - Background Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes. Results Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.

AB - Background Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. Objectives We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). Methods First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes. Results Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). Conclusion Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.

KW - gestational age

KW - low birth weight

KW - infant growth

KW - wheezing

KW - asthma

KW - children

KW - cohort Studies

KW - epidemiology

U2 - 10.1016/j.jaci.2013.12.1082

DO - 10.1016/j.jaci.2013.12.1082

M3 - Article

VL - 133

SP - 1317

EP - 1329

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 5

ER -