Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort

Louisa Owens, Ingrid A. Laing, Guicheng Zhang, Stephen Turner, Peter N. le Souëf

Research output: Contribution to journalArticle

2 Citations (Scopus)
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Abstract

Purpose: The aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood in a single cohort.
Participants and methods: This prospective study is based on a longitudinal birth cohort of 253 participants, with respiratory and immunological assessments at 1, 6, 11, 18 and 24 years of age. Subjects were recruited from an urban maternity hospital. Retention rates varied from 45% to 72% at follow-up assessments. Asthma diagnosis was based on physician diagnosis of asthma and symptoms/medications in the previous 12 months. Allergic sensitization was defined by the positive skin prick test. Hay fever and eczema were based on a questionnaire.
Results: The prevalence of allergic sensitization rose from 19% (n=33) at 1 year of age to 71% (n=77) at 24 years of age. The rate of asthma halved from 25% at 6 years of age to 12%–15% between 11 and 24 years of age, but the prevalence of allergic sensitization among those with asthma doubled from 50% at 6 years of age to 100% at 24 years of age. Hay fever rates rose throughout childhood from 7% at 6 years of age to 44% at 24 years of age, while the prevalence of eczema reduced from 25% at 6 years of age to 16% at 24 years of age. Parental atopy doubled the odds of asthma in their offspring by 24 years of age (odds ratio [OR]= 2.63, 95% CI 1.1–6.2, p=0.029). In all, 74% of those with asthma at 24 years of age also reported hay fever. The relationship between eczema and asthma was only significant up to 11 years of age, and the relationship between hay fever and asthma was stronger in adolescence and early adulthood than in early childhood.
Conclusion: Patterns of atopic disorders vary throughout childhood. Although the prevalence of allergic sensitization and hay fever rose throughout childhood and the prevalence of asthma reduced, the strength of their relationship with asthma increased with age.
Original languageEnglish
Pages (from-to)173-180
Number of pages8
JournalJournal of Asthma and Allergy
Volume11
DOIs
Publication statusPublished - 13 Aug 2018

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Seasonal Allergic Rhinitis
Eczema
Asthma
Parturition
Maternity Hospitals
Urban Hospitals
Skin Tests
Odds Ratio
Prospective Studies
Physicians

Keywords

  • allergy
  • rhinitis
  • childhood
  • adolescence

Cite this

Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort. / Owens, Louisa; Laing, Ingrid A.; Zhang, Guicheng; Turner, Stephen; le Souëf, Peter N.

In: Journal of Asthma and Allergy, Vol. 11, 13.08.2018, p. 173-180.

Research output: Contribution to journalArticle

Owens, Louisa ; Laing, Ingrid A. ; Zhang, Guicheng ; Turner, Stephen ; le Souëf, Peter N. / Prevalence of allergic sensitization, hay fever, eczema, and asthma in a longitudinal birth cohort. In: Journal of Asthma and Allergy. 2018 ; Vol. 11. pp. 173-180.
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abstract = "Purpose: The aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood in a single cohort.Participants and methods: This prospective study is based on a longitudinal birth cohort of 253 participants, with respiratory and immunological assessments at 1, 6, 11, 18 and 24 years of age. Subjects were recruited from an urban maternity hospital. Retention rates varied from 45{\%} to 72{\%} at follow-up assessments. Asthma diagnosis was based on physician diagnosis of asthma and symptoms/medications in the previous 12 months. Allergic sensitization was defined by the positive skin prick test. Hay fever and eczema were based on a questionnaire.Results: The prevalence of allergic sensitization rose from 19{\%} (n=33) at 1 year of age to 71{\%} (n=77) at 24 years of age. The rate of asthma halved from 25{\%} at 6 years of age to 12{\%}–15{\%} between 11 and 24 years of age, but the prevalence of allergic sensitization among those with asthma doubled from 50{\%} at 6 years of age to 100{\%} at 24 years of age. Hay fever rates rose throughout childhood from 7{\%} at 6 years of age to 44{\%} at 24 years of age, while the prevalence of eczema reduced from 25{\%} at 6 years of age to 16{\%} at 24 years of age. Parental atopy doubled the odds of asthma in their offspring by 24 years of age (odds ratio [OR]= 2.63, 95{\%} CI 1.1–6.2, p=0.029). In all, 74{\%} of those with asthma at 24 years of age also reported hay fever. The relationship between eczema and asthma was only significant up to 11 years of age, and the relationship between hay fever and asthma was stronger in adolescence and early adulthood than in early childhood.Conclusion: Patterns of atopic disorders vary throughout childhood. Although the prevalence of allergic sensitization and hay fever rose throughout childhood and the prevalence of asthma reduced, the strength of their relationship with asthma increased with age.",
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note = "We would like to thank all the previous contributors to the PIAF study including David Mullane, Desmond Cox, Kimberley Franks, Lou Landau, Jack Goldblatt, Sally Young, Siew-Kim Khoo, Neil Gibson, Veena Judge, Lyle Palmer, Paul O’Keefe, Jackie Arnott, Steve Stick and Peter Rye. This study was funded by NHMRC research grant APP1031635, Princess Margaret Hospital Foundation Seeding grant 9383; University of Western Australia PhD scholarship and Asthma Foundation of Western Australia PhD top-up scholarship. The sponsors had no role in the design of this study or writing of this manuscript.",
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AU - Laing, Ingrid A.

AU - Zhang, Guicheng

AU - Turner, Stephen

AU - le Souëf, Peter N.

N1 - We would like to thank all the previous contributors to the PIAF study including David Mullane, Desmond Cox, Kimberley Franks, Lou Landau, Jack Goldblatt, Sally Young, Siew-Kim Khoo, Neil Gibson, Veena Judge, Lyle Palmer, Paul O’Keefe, Jackie Arnott, Steve Stick and Peter Rye. This study was funded by NHMRC research grant APP1031635, Princess Margaret Hospital Foundation Seeding grant 9383; University of Western Australia PhD scholarship and Asthma Foundation of Western Australia PhD top-up scholarship. The sponsors had no role in the design of this study or writing of this manuscript.

PY - 2018/8/13

Y1 - 2018/8/13

N2 - Purpose: The aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood in a single cohort.Participants and methods: This prospective study is based on a longitudinal birth cohort of 253 participants, with respiratory and immunological assessments at 1, 6, 11, 18 and 24 years of age. Subjects were recruited from an urban maternity hospital. Retention rates varied from 45% to 72% at follow-up assessments. Asthma diagnosis was based on physician diagnosis of asthma and symptoms/medications in the previous 12 months. Allergic sensitization was defined by the positive skin prick test. Hay fever and eczema were based on a questionnaire.Results: The prevalence of allergic sensitization rose from 19% (n=33) at 1 year of age to 71% (n=77) at 24 years of age. The rate of asthma halved from 25% at 6 years of age to 12%–15% between 11 and 24 years of age, but the prevalence of allergic sensitization among those with asthma doubled from 50% at 6 years of age to 100% at 24 years of age. Hay fever rates rose throughout childhood from 7% at 6 years of age to 44% at 24 years of age, while the prevalence of eczema reduced from 25% at 6 years of age to 16% at 24 years of age. Parental atopy doubled the odds of asthma in their offspring by 24 years of age (odds ratio [OR]= 2.63, 95% CI 1.1–6.2, p=0.029). In all, 74% of those with asthma at 24 years of age also reported hay fever. The relationship between eczema and asthma was only significant up to 11 years of age, and the relationship between hay fever and asthma was stronger in adolescence and early adulthood than in early childhood.Conclusion: Patterns of atopic disorders vary throughout childhood. Although the prevalence of allergic sensitization and hay fever rose throughout childhood and the prevalence of asthma reduced, the strength of their relationship with asthma increased with age.

AB - Purpose: The aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood in a single cohort.Participants and methods: This prospective study is based on a longitudinal birth cohort of 253 participants, with respiratory and immunological assessments at 1, 6, 11, 18 and 24 years of age. Subjects were recruited from an urban maternity hospital. Retention rates varied from 45% to 72% at follow-up assessments. Asthma diagnosis was based on physician diagnosis of asthma and symptoms/medications in the previous 12 months. Allergic sensitization was defined by the positive skin prick test. Hay fever and eczema were based on a questionnaire.Results: The prevalence of allergic sensitization rose from 19% (n=33) at 1 year of age to 71% (n=77) at 24 years of age. The rate of asthma halved from 25% at 6 years of age to 12%–15% between 11 and 24 years of age, but the prevalence of allergic sensitization among those with asthma doubled from 50% at 6 years of age to 100% at 24 years of age. Hay fever rates rose throughout childhood from 7% at 6 years of age to 44% at 24 years of age, while the prevalence of eczema reduced from 25% at 6 years of age to 16% at 24 years of age. Parental atopy doubled the odds of asthma in their offspring by 24 years of age (odds ratio [OR]= 2.63, 95% CI 1.1–6.2, p=0.029). In all, 74% of those with asthma at 24 years of age also reported hay fever. The relationship between eczema and asthma was only significant up to 11 years of age, and the relationship between hay fever and asthma was stronger in adolescence and early adulthood than in early childhood.Conclusion: Patterns of atopic disorders vary throughout childhood. Although the prevalence of allergic sensitization and hay fever rose throughout childhood and the prevalence of asthma reduced, the strength of their relationship with asthma increased with age.

KW - allergy

KW - rhinitis

KW - childhood

KW - adolescence

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JO - Journal of Asthma and Allergy

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