Prevalence of defined ultrasound findings of unknown significance at the second trimester fetal anomaly scan and their association with adverse pregnancy outcomes: the Welsh study of mothers and babies population-based cohort

Lisa Hurt, Melissa Wright, Frank Dunstan, Susan Thomas, Fiona Brook, Susan Morris, David Tucker, Marilyn Ann Wills, Colin Davies, Gareth John, David Fone, Shantini Paranjothy

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective The aim of this article was to estimate the population prevalence of seven defined ultrasound findings of uncertain significance (?markers?) in the second trimester and the associated risk of adverse pregnancy outcomes. Method A prospective record-linked cohort study of 30 078 pregnant women who had second trimester anomaly scans between July 2008 and March 2011 in Wales was conducted. Results The prevalence of markers ranged from 43.7 per 1000 singleton pregnancies for cardiac echogenic foci [95% confidence interval (CI): 38.8, 51.1] to 0.6 for mild-to-moderate ventriculomegaly (95% CI: 0.3, 1.0). Isolated echogenic bowel was associated with an increased risk of congenital anomalies [risk ratio (RR) 4.54, 95% CI: 2.12, 9.73] and preterm birth (RR 2.30, 95% CI: 1.08, 4.90). Isolated pelvicalyceal dilatation was associated with an increased risk of congenital anomalies (RR 3.82, 95% CI: 2.16, 6.77). Multiple markers were associated with an increased risk of congenital anomalies (RR 5.00, 95% CI: 1.35, 18.40) and preterm birth (RR 3.38, 95% CI 1.20, 9.53). Conclusions These data are useful for counselling families and developing clinical guidance and care pathways following the detection of markers in clinical practice, particularly the need for follow-up scans to monitor placental function and growth in pregnancies with isolated echogenic bowel, and further investigation for multiple markers
Original languageEnglish
Pages (from-to)40-48
Number of pages9
JournalPrenatal Diagnosis
Volume36
Issue number1
Early online date20 Nov 2015
DOIs
Publication statusPublished - Jan 2016

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