TY - JOUR
T1 - Prevalence of human papillomavirus in women attending cervical screening in the UK and Ireland
T2 - New data from northern Ireland and a systematic review and meta-analysis
AU - Anderson, Lesley
AU - O'Rorke, Michael
AU - Jamison, Jackie
AU - Wilson, Robbie
AU - Gavin, Anna
AU - the HPV Working Group members
N1 - The Northern Ireland cancer registry is funded by the Public Health Agency for Northern Ireland. We thank the Northern Ireland HPV working group members for their contribution: Boyle, M. (Department of Health, Social Services and Public Safety); Owen, T. (Public Health Agency); Irvine, N. (Public Health Agency); Clarke, R. (Southern Health & Social Care [HSC] Trust); McCluggage, G. (Belfast HSC Trust); Coyle, P. (Belfast HSC Trust); McCance, D. (Queen's University Belfast); Carson, J. (Northern HSC Trust); Cameron, I. (Western HSC Trust) and McGibben, D. (Belfast HSC Trust).
PY - 2013/2/1
Y1 - 2013/2/1
N2 - There is substantial international variation in human papillomavirus (HPV) prevalence; this study details the first report from Northern Ireland and additionally provides a systematic review and meta-analysis pooling the prevalence of high-risk (HR-HPV) subtypes among women with normal cytology in the UK and Ireland. Between February and December 2009, routine liquid based cytology (LBC) samples were collected for HPV detection (Roche Cobas® 4800 [PCR]) among unselected women attending for cervical cytology testing. Four electronic databases, including MEDLINE, were then searched from their inception till April 2011. A random effects meta-analysis was used to calculate a pooled HR-HPV prevalence and associated 95% confidence intervals (CI). 5,712 women, mean age 39 years (±SD 11.9 years; range 20-64 years), were included in the analysis, of which 5,068 (88.7%), 417 (7.3%) and 72 (1.3%) had normal, low, and high-grade cytological findings, respectively. Crude HR-HPV prevalence was 13.2% (95% CI, 12.7-13.7) among women with normal cytology and increased with cytological grade. In meta-analysis the pooled HR-HPV prevalence among those with normal cytology was 0.12 (95% CIs, 0.10-0.14; 21 studies) with the highest prevalence in younger women. HPV 16 and HPV 18 specific estimates were 0.03 (95% CI, 0.02-0.05) and 0.01 (95% CI, 0.01-0.02), respectively. The findings of this Northern Ireland study and meta-analysis verify the prevalent nature of HPV infection among younger women. Reporting of the type-specific prevalence of HPV infection is relevant for evaluating the impact of future HPV immunization initiatives, particularly against HR-HPV types other than HPV 16 and 18. J. Med. Virol. 85:295-308, 2013. © 2012 Wiley Periodicals, Inc.
AB - There is substantial international variation in human papillomavirus (HPV) prevalence; this study details the first report from Northern Ireland and additionally provides a systematic review and meta-analysis pooling the prevalence of high-risk (HR-HPV) subtypes among women with normal cytology in the UK and Ireland. Between February and December 2009, routine liquid based cytology (LBC) samples were collected for HPV detection (Roche Cobas® 4800 [PCR]) among unselected women attending for cervical cytology testing. Four electronic databases, including MEDLINE, were then searched from their inception till April 2011. A random effects meta-analysis was used to calculate a pooled HR-HPV prevalence and associated 95% confidence intervals (CI). 5,712 women, mean age 39 years (±SD 11.9 years; range 20-64 years), were included in the analysis, of which 5,068 (88.7%), 417 (7.3%) and 72 (1.3%) had normal, low, and high-grade cytological findings, respectively. Crude HR-HPV prevalence was 13.2% (95% CI, 12.7-13.7) among women with normal cytology and increased with cytological grade. In meta-analysis the pooled HR-HPV prevalence among those with normal cytology was 0.12 (95% CIs, 0.10-0.14; 21 studies) with the highest prevalence in younger women. HPV 16 and HPV 18 specific estimates were 0.03 (95% CI, 0.02-0.05) and 0.01 (95% CI, 0.01-0.02), respectively. The findings of this Northern Ireland study and meta-analysis verify the prevalent nature of HPV infection among younger women. Reporting of the type-specific prevalence of HPV infection is relevant for evaluating the impact of future HPV immunization initiatives, particularly against HR-HPV types other than HPV 16 and 18. J. Med. Virol. 85:295-308, 2013. © 2012 Wiley Periodicals, Inc.
KW - Human papillomavirus (HPV)
KW - Meta-analysis
KW - Normal cytology
KW - Systematic review
UR - http://www.scopus.com/inward/record.url?scp=84871167955&partnerID=8YFLogxK
U2 - 10.1002/jmv.23459
DO - 10.1002/jmv.23459
M3 - Article
C2 - 23161367
AN - SCOPUS:84871167955
VL - 85
SP - 295
EP - 308
JO - Journal of Medical Virology
JF - Journal of Medical Virology
SN - 1096-9071
IS - 2
ER -