TY - JOUR
T1 - Prevalence of non-fracture short vertebral height is similar in premenopausal and postmenopausal women
T2 - The osteoporosis and ultrasound study
AU - Ferrar, L.
AU - Roux, C.
AU - Reid, D. M.
AU - Felsenberg, D.
AU - Glüer, C. C.
AU - Eastell, R.
N1 - Acknowledgements
The OPUS study was sponsored by Eli Lilly, Sanofi–Aventis, Procter & Gamble Pharmaceuticals, Hoffman-La Roche, Pfizer and Novartis, and we acknowledge the support of the National
Institute for Health Research, UK, via its Biomedical Research Units funding scheme. We thank the following members of the OPUS teams at the five participating centres for their contributions: Alison Stewart, Rosie Reid and Lana Gibson (Aberdeen); the members of the Zentrum fur Muskel und Knochenforschung (Berlin), Gabriele Armbrecht, Friederike Tomasius, Frank Touby, Martina Kratzsch and Tilo Blenk; Reinhard Barkmann, Wolframm Timm, Antonia Gerwin, Maren Glüer, Roswitha John, Roswitha Marunde-Ott, Marika Mohr, Regina Schlenger, Pia
Zschoche, Carsten Liess and Carsten Rose (Kiel); Therese Kolta and Nathalie Delfau (Paris) and Jackie Clowes, Margaret Paggiosi, Nicky Peel, Judy Finigan and Debbie Swindell (Sheffield).
PY - 2012/3
Y1 - 2012/3
N2 - We observed similar prevalence of short vertebral height without endplate depression (SVH) in young women aged 20-39 years and older women aged 55-79 years. There was no association between SVH and low bone density. In older women, therefore, SVH may be largely long standing and not indicative of osteoporotic fracture. Introduction: Algorithm-based qualitative (ABQ) definition of osteoporotic vertebral fracture (VF) requires evidence of endplate fracture, and there is no minimum threshold for apparent 'reduction' in vertebral height. In older women, SVH without endplate fracture identified on baseline assessment may be long standing and unrelated to VF. If this is so, we would expect to see a similar prevalence of SVH in younger women. We aimed to compare the prevalence of pre- and postmenopausal women with SVH and the characteristics of women with and without SVH. Methods: We used the ABQ method to classify baseline vertebral images (DXA-based imaging) from 257 premenopausal and 1,361 postmenopausal women participating in the population-based Osteoporosis and Ultrasound Study. Images were classified as follows: normal (no VF, no SVH), SVH (no VF) or VF (with/without SVH in unfractured vertebrae). We compared proportions of women with SVH (chi-squared test) and compared age, height, weight and bone mineral density (BMD) by ABQ classification (two-sample t test/analysis of variance). Results: The prevalence of pre- and postmenopausal women with SVH was 37% and 33%, respectively (P>0.05). Compared to women without SVH, premenopausal women with SVH were older (P<0.001) and heavier (P=0.05), and postmenopausal women with SVH were taller (P<0.05), with higher spine BMD (P<0.01). Postmenopausal women with VF were older (P<0.001) and shorter (P<0.01) with lower BMD (P<0.001) than women without VF. Conclusions: Short vertebral height without endplate fracture is equally prevalent in pre- and postmenopausal women and not associated with low bone density.
AB - We observed similar prevalence of short vertebral height without endplate depression (SVH) in young women aged 20-39 years and older women aged 55-79 years. There was no association between SVH and low bone density. In older women, therefore, SVH may be largely long standing and not indicative of osteoporotic fracture. Introduction: Algorithm-based qualitative (ABQ) definition of osteoporotic vertebral fracture (VF) requires evidence of endplate fracture, and there is no minimum threshold for apparent 'reduction' in vertebral height. In older women, SVH without endplate fracture identified on baseline assessment may be long standing and unrelated to VF. If this is so, we would expect to see a similar prevalence of SVH in younger women. We aimed to compare the prevalence of pre- and postmenopausal women with SVH and the characteristics of women with and without SVH. Methods: We used the ABQ method to classify baseline vertebral images (DXA-based imaging) from 257 premenopausal and 1,361 postmenopausal women participating in the population-based Osteoporosis and Ultrasound Study. Images were classified as follows: normal (no VF, no SVH), SVH (no VF) or VF (with/without SVH in unfractured vertebrae). We compared proportions of women with SVH (chi-squared test) and compared age, height, weight and bone mineral density (BMD) by ABQ classification (two-sample t test/analysis of variance). Results: The prevalence of pre- and postmenopausal women with SVH was 37% and 33%, respectively (P>0.05). Compared to women without SVH, premenopausal women with SVH were older (P<0.001) and heavier (P=0.05), and postmenopausal women with SVH were taller (P<0.05), with higher spine BMD (P<0.01). Postmenopausal women with VF were older (P<0.001) and shorter (P<0.01) with lower BMD (P<0.001) than women without VF. Conclusions: Short vertebral height without endplate fracture is equally prevalent in pre- and postmenopausal women and not associated with low bone density.
KW - Bone mineral density
KW - Dual-energy x-ray absorptiometry
KW - Osteoporosis
KW - Vertebral fracture
UR - http://www.scopus.com/inward/record.url?scp=84857441711&partnerID=8YFLogxK
U2 - 10.1007/s00198-011-1657-3
DO - 10.1007/s00198-011-1657-3
M3 - Article
C2 - 21611843
AN - SCOPUS:84857441711
VL - 23
SP - 1035
EP - 1040
JO - Osteoporosis International
JF - Osteoporosis International
SN - 0937-941X
IS - 3
ER -
