Prevalence of osteoporotic bone mineral density at the hip in Britain differs substantially from the US over 50 years of age: implications for clinical densitometry

G Holt, K T Khaw, D M Reid, J E Compston, A Bhalla, A D Woolf, N J Crabtree, N Dalzell, B Wardley-Smith, M Lunt, J Reeve

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The purpose of this study was to compare hip bone mineral density (BMD) recorded in seven population based cohorts in Britain with the third National Health and Nutrition Examination Survey (NHANES III) US population-based reference data, in order to assess geographic variation in the prevalence of osteoporosis. Men and women aged 50-80+ years were randomly recruited from population and health registers. Dual X-ray absorptiometry (DXA) equipment was used to measure BMD at the hip, with the femoral neck and the trochanter regions studied. Prevalences of osteopenia and osteoporosis were estimated in accordance with World Health Organisation diagnostic criteria for women. Young normal data, used to establish cut-off criteria, was from NHANES III. Both male and female British subjects over 50-years-old were found to have significantly higher mean BMD at the femoral neck and trochanter than their US counterparts. Decline in BMD with age in British men appeared slower than in US men. Between British centres there were also statistically significant differences in BMD values in both sexes. British age-adjusted prevalences of osteopenia in women averaged 20% less than those of NHANES III, whereas the prevalence of osteoporosis was substantially lower in British subjects of both sexes (55% in women, 68% in men). Thus, applying the US NHANES III data as the referent, osteoporosis of the proximal femur in Britain appears to be less common than in the US, due primarily to differences in the lower tails of the BMD distributions. Providing that the relationship between fracture rates and BMD is the same in Britain and the US, it would still be appropriate to apply the reference data in fracture risk assessment in the UK.

Original languageEnglish
Pages (from-to)736-742
Number of pages7
JournalBritish Journal of Radiology
Volume75
Publication statusPublished - 2002

Keywords

  • X-RAY ABSORPTIOMETRY
  • VERTEBRAL OSTEOPOROSIS
  • PROXIMAL FEMUR
  • SPINE PHANTOM
  • NHANES-III
  • WOMEN
  • MEN
  • DIAGNOSIS
  • DEFORMITY
  • ADULTS

Cite this

Prevalence of osteoporotic bone mineral density at the hip in Britain differs substantially from the US over 50 years of age: implications for clinical densitometry. / Holt, G ; Khaw, K T ; Reid, D M ; Compston, J E ; Bhalla, A ; Woolf, A D ; Crabtree, N J ; Dalzell, N ; Wardley-Smith, B ; Lunt, M ; Reeve, J .

In: British Journal of Radiology, Vol. 75, 2002, p. 736-742.

Research output: Contribution to journalArticle

Holt, G, Khaw, KT, Reid, DM, Compston, JE, Bhalla, A, Woolf, AD, Crabtree, NJ, Dalzell, N, Wardley-Smith, B, Lunt, M & Reeve, J 2002, 'Prevalence of osteoporotic bone mineral density at the hip in Britain differs substantially from the US over 50 years of age: implications for clinical densitometry', British Journal of Radiology, vol. 75, pp. 736-742.
Holt, G ; Khaw, K T ; Reid, D M ; Compston, J E ; Bhalla, A ; Woolf, A D ; Crabtree, N J ; Dalzell, N ; Wardley-Smith, B ; Lunt, M ; Reeve, J . / Prevalence of osteoporotic bone mineral density at the hip in Britain differs substantially from the US over 50 years of age: implications for clinical densitometry. In: British Journal of Radiology. 2002 ; Vol. 75. pp. 736-742.
@article{ad2736b134254e099879c424ec31f68f,
title = "Prevalence of osteoporotic bone mineral density at the hip in Britain differs substantially from the US over 50 years of age: implications for clinical densitometry",
abstract = "The purpose of this study was to compare hip bone mineral density (BMD) recorded in seven population based cohorts in Britain with the third National Health and Nutrition Examination Survey (NHANES III) US population-based reference data, in order to assess geographic variation in the prevalence of osteoporosis. Men and women aged 50-80+ years were randomly recruited from population and health registers. Dual X-ray absorptiometry (DXA) equipment was used to measure BMD at the hip, with the femoral neck and the trochanter regions studied. Prevalences of osteopenia and osteoporosis were estimated in accordance with World Health Organisation diagnostic criteria for women. Young normal data, used to establish cut-off criteria, was from NHANES III. Both male and female British subjects over 50-years-old were found to have significantly higher mean BMD at the femoral neck and trochanter than their US counterparts. Decline in BMD with age in British men appeared slower than in US men. Between British centres there were also statistically significant differences in BMD values in both sexes. British age-adjusted prevalences of osteopenia in women averaged 20{\%} less than those of NHANES III, whereas the prevalence of osteoporosis was substantially lower in British subjects of both sexes (55{\%} in women, 68{\%} in men). Thus, applying the US NHANES III data as the referent, osteoporosis of the proximal femur in Britain appears to be less common than in the US, due primarily to differences in the lower tails of the BMD distributions. Providing that the relationship between fracture rates and BMD is the same in Britain and the US, it would still be appropriate to apply the reference data in fracture risk assessment in the UK.",
keywords = "X-RAY ABSORPTIOMETRY, VERTEBRAL OSTEOPOROSIS, PROXIMAL FEMUR, SPINE PHANTOM, NHANES-III, WOMEN, MEN, DIAGNOSIS, DEFORMITY, ADULTS",
author = "G Holt and Khaw, {K T} and Reid, {D M} and Compston, {J E} and A Bhalla and Woolf, {A D} and Crabtree, {N J} and N Dalzell and B Wardley-Smith and M Lunt and J Reeve",
year = "2002",
language = "English",
volume = "75",
pages = "736--742",
journal = "British Journal of Radiology",
issn = "0007-1285",
publisher = "British Institute of Radiology",

}

TY - JOUR

T1 - Prevalence of osteoporotic bone mineral density at the hip in Britain differs substantially from the US over 50 years of age: implications for clinical densitometry

AU - Holt, G

AU - Khaw, K T

AU - Reid, D M

AU - Compston, J E

AU - Bhalla, A

AU - Woolf, A D

AU - Crabtree, N J

AU - Dalzell, N

AU - Wardley-Smith, B

AU - Lunt, M

AU - Reeve, J

PY - 2002

Y1 - 2002

N2 - The purpose of this study was to compare hip bone mineral density (BMD) recorded in seven population based cohorts in Britain with the third National Health and Nutrition Examination Survey (NHANES III) US population-based reference data, in order to assess geographic variation in the prevalence of osteoporosis. Men and women aged 50-80+ years were randomly recruited from population and health registers. Dual X-ray absorptiometry (DXA) equipment was used to measure BMD at the hip, with the femoral neck and the trochanter regions studied. Prevalences of osteopenia and osteoporosis were estimated in accordance with World Health Organisation diagnostic criteria for women. Young normal data, used to establish cut-off criteria, was from NHANES III. Both male and female British subjects over 50-years-old were found to have significantly higher mean BMD at the femoral neck and trochanter than their US counterparts. Decline in BMD with age in British men appeared slower than in US men. Between British centres there were also statistically significant differences in BMD values in both sexes. British age-adjusted prevalences of osteopenia in women averaged 20% less than those of NHANES III, whereas the prevalence of osteoporosis was substantially lower in British subjects of both sexes (55% in women, 68% in men). Thus, applying the US NHANES III data as the referent, osteoporosis of the proximal femur in Britain appears to be less common than in the US, due primarily to differences in the lower tails of the BMD distributions. Providing that the relationship between fracture rates and BMD is the same in Britain and the US, it would still be appropriate to apply the reference data in fracture risk assessment in the UK.

AB - The purpose of this study was to compare hip bone mineral density (BMD) recorded in seven population based cohorts in Britain with the third National Health and Nutrition Examination Survey (NHANES III) US population-based reference data, in order to assess geographic variation in the prevalence of osteoporosis. Men and women aged 50-80+ years were randomly recruited from population and health registers. Dual X-ray absorptiometry (DXA) equipment was used to measure BMD at the hip, with the femoral neck and the trochanter regions studied. Prevalences of osteopenia and osteoporosis were estimated in accordance with World Health Organisation diagnostic criteria for women. Young normal data, used to establish cut-off criteria, was from NHANES III. Both male and female British subjects over 50-years-old were found to have significantly higher mean BMD at the femoral neck and trochanter than their US counterparts. Decline in BMD with age in British men appeared slower than in US men. Between British centres there were also statistically significant differences in BMD values in both sexes. British age-adjusted prevalences of osteopenia in women averaged 20% less than those of NHANES III, whereas the prevalence of osteoporosis was substantially lower in British subjects of both sexes (55% in women, 68% in men). Thus, applying the US NHANES III data as the referent, osteoporosis of the proximal femur in Britain appears to be less common than in the US, due primarily to differences in the lower tails of the BMD distributions. Providing that the relationship between fracture rates and BMD is the same in Britain and the US, it would still be appropriate to apply the reference data in fracture risk assessment in the UK.

KW - X-RAY ABSORPTIOMETRY

KW - VERTEBRAL OSTEOPOROSIS

KW - PROXIMAL FEMUR

KW - SPINE PHANTOM

KW - NHANES-III

KW - WOMEN

KW - MEN

KW - DIAGNOSIS

KW - DEFORMITY

KW - ADULTS

M3 - Article

VL - 75

SP - 736

EP - 742

JO - British Journal of Radiology

JF - British Journal of Radiology

SN - 0007-1285

ER -