Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: Results from the European Prospective Osteoporosis Study

A A Ismail, W Cockerill, C Cooper, J D Finn, K Abendroth, G Parisi, D Banzer, L I Benevolenskaya, A K Bhalla, J B Armas, J B Cannata, P D Delmas, J Dequeker, G Dilsen, R Eastell, O Ershova, J A Falch, B Felsch, S Havelka, K Hoszowski & 30 others I Jajic, U Kragl, O Johnell, A L Vaz, R Lorenc, G Lyritis, F Marchand, P Masaryk, C Matthis, T Miazgowski, H A P Pols, G Poor, A Rapado, H H Raspe, D M Reid, W Reisinger, J Janott, C Scheidt-Nave, J Stepan, C Todd, K Weber, A D Woolf, G Ambrecht, W Gowin, D Felsenberg, M Lunt, J A Kanis, J Reeve, A J Silman, T W O'Neill

Research output: Contribution to journalArticle

140 Citations (Scopus)

Abstract

The presence of a vertebral deformity increases the risk of subsequent spinal deformities. The aim of this analysis was to determine whether the presence of vertebral deformity predicts incident hip and other limb fractures. Six thousand three hundred and forty-four men and 6788 women aged 50 years and over were recruited from population registers in 31 European centers and followed prospectively for a median of 3 years. All subjects had radiographs performed at baseline and the presence of vertebral deformity was assessed using established morphometric methods. Incident limb fractures which occurred during the follow- up period were ascertained by annual postal questionnaire and confirmed by radiographs, review of medical records and personal interview. During a total of 40348 person-years of follow-up, 138 men and 391 women sustained a limb fracture, Amongst the women, after adjustment for age, prevalent vertebral deformity was a strong predictor of incident hip fracture, (rate ratio (RR) = 4.5; 95% CI 2.1-9.4) and a weak predictor of 'other' limb fractures (RR = 1.6; 95% CI 1.1-2.4), though not distal forearm fracture (RR = 1.0; 95% CI 0.6-1.6). The predictive risk increased with increasing number of prevalent deformities, particularly for subsequent hip fracture: for two or more deformities, RIE = 7.2 (95% CI 3.0-17.3). Amongst men, vertebral deformity was not associated with an increased risk of incident limb fracture though there was a nonsignificant trend toward an increased risk of hip fracture with increasing number of deformities. In summary, prevalent radiographic vertebral deformities in women are a strong predictor of hip fracture, and to a lesser extent humerus and 'other' limb fractures; however, they do not predict distal forearm fractures.

Original languageEnglish
Pages (from-to)85-90
Number of pages6
JournalOsteoporosis International
Volume12
Publication statusPublished - 2001

Keywords

  • incidence
  • limb fracture
  • osteoporosis
  • vertebral deformity
  • vertebral osteoporosis
  • RISK-FACTORS
  • WRIST FRACTURES
  • BONE MASS
  • WOMEN
  • MEN
  • POPULATION
  • WELL

Cite this

Ismail, A. A., Cockerill, W., Cooper, C., Finn, J. D., Abendroth, K., Parisi, G., ... O'Neill, T. W. (2001). Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: Results from the European Prospective Osteoporosis Study. Osteoporosis International, 12, 85-90.

Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: Results from the European Prospective Osteoporosis Study. / Ismail, A A ; Cockerill, W ; Cooper, C ; Finn, J D ; Abendroth, K ; Parisi, G ; Banzer, D ; Benevolenskaya, L I ; Bhalla, A K ; Armas, J B ; Cannata, J B ; Delmas, P D ; Dequeker, J ; Dilsen, G ; Eastell, R ; Ershova, O ; Falch, J A ; Felsch, B ; Havelka, S ; Hoszowski, K ; Jajic, I ; Kragl, U ; Johnell, O ; Vaz, A L ; Lorenc, R ; Lyritis, G ; Marchand, F ; Masaryk, P ; Matthis, C ; Miazgowski, T ; Pols, H A P ; Poor, G ; Rapado, A ; Raspe, H H ; Reid, D M ; Reisinger, W ; Janott, J ; Scheidt-Nave, C ; Stepan, J ; Todd, C ; Weber, K ; Woolf, A D ; Ambrecht, G ; Gowin, W ; Felsenberg, D ; Lunt, M ; Kanis, J A ; Reeve, J ; Silman, A J ; O'Neill, T W .

In: Osteoporosis International, Vol. 12, 2001, p. 85-90.

Research output: Contribution to journalArticle

Ismail, AA, Cockerill, W, Cooper, C, Finn, JD, Abendroth, K, Parisi, G, Banzer, D, Benevolenskaya, LI, Bhalla, AK, Armas, JB, Cannata, JB, Delmas, PD, Dequeker, J, Dilsen, G, Eastell, R, Ershova, O, Falch, JA, Felsch, B, Havelka, S, Hoszowski, K, Jajic, I, Kragl, U, Johnell, O, Vaz, AL, Lorenc, R, Lyritis, G, Marchand, F, Masaryk, P, Matthis, C, Miazgowski, T, Pols, HAP, Poor, G, Rapado, A, Raspe, HH, Reid, DM, Reisinger, W, Janott, J, Scheidt-Nave, C, Stepan, J, Todd, C, Weber, K, Woolf, AD, Ambrecht, G, Gowin, W, Felsenberg, D, Lunt, M, Kanis, JA, Reeve, J, Silman, AJ & O'Neill, TW 2001, 'Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: Results from the European Prospective Osteoporosis Study', Osteoporosis International, vol. 12, pp. 85-90.
Ismail, A A ; Cockerill, W ; Cooper, C ; Finn, J D ; Abendroth, K ; Parisi, G ; Banzer, D ; Benevolenskaya, L I ; Bhalla, A K ; Armas, J B ; Cannata, J B ; Delmas, P D ; Dequeker, J ; Dilsen, G ; Eastell, R ; Ershova, O ; Falch, J A ; Felsch, B ; Havelka, S ; Hoszowski, K ; Jajic, I ; Kragl, U ; Johnell, O ; Vaz, A L ; Lorenc, R ; Lyritis, G ; Marchand, F ; Masaryk, P ; Matthis, C ; Miazgowski, T ; Pols, H A P ; Poor, G ; Rapado, A ; Raspe, H H ; Reid, D M ; Reisinger, W ; Janott, J ; Scheidt-Nave, C ; Stepan, J ; Todd, C ; Weber, K ; Woolf, A D ; Ambrecht, G ; Gowin, W ; Felsenberg, D ; Lunt, M ; Kanis, J A ; Reeve, J ; Silman, A J ; O'Neill, T W . / Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: Results from the European Prospective Osteoporosis Study. In: Osteoporosis International. 2001 ; Vol. 12. pp. 85-90.
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title = "Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: Results from the European Prospective Osteoporosis Study",
abstract = "The presence of a vertebral deformity increases the risk of subsequent spinal deformities. The aim of this analysis was to determine whether the presence of vertebral deformity predicts incident hip and other limb fractures. Six thousand three hundred and forty-four men and 6788 women aged 50 years and over were recruited from population registers in 31 European centers and followed prospectively for a median of 3 years. All subjects had radiographs performed at baseline and the presence of vertebral deformity was assessed using established morphometric methods. Incident limb fractures which occurred during the follow- up period were ascertained by annual postal questionnaire and confirmed by radiographs, review of medical records and personal interview. During a total of 40348 person-years of follow-up, 138 men and 391 women sustained a limb fracture, Amongst the women, after adjustment for age, prevalent vertebral deformity was a strong predictor of incident hip fracture, (rate ratio (RR) = 4.5; 95{\%} CI 2.1-9.4) and a weak predictor of 'other' limb fractures (RR = 1.6; 95{\%} CI 1.1-2.4), though not distal forearm fracture (RR = 1.0; 95{\%} CI 0.6-1.6). The predictive risk increased with increasing number of prevalent deformities, particularly for subsequent hip fracture: for two or more deformities, RIE = 7.2 (95{\%} CI 3.0-17.3). Amongst men, vertebral deformity was not associated with an increased risk of incident limb fracture though there was a nonsignificant trend toward an increased risk of hip fracture with increasing number of deformities. In summary, prevalent radiographic vertebral deformities in women are a strong predictor of hip fracture, and to a lesser extent humerus and 'other' limb fractures; however, they do not predict distal forearm fractures.",
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TY - JOUR

T1 - Prevalent vertebral deformity predicts incident hip though not distal forearm fracture: Results from the European Prospective Osteoporosis Study

AU - Ismail, A A

AU - Cockerill, W

AU - Cooper, C

AU - Finn, J D

AU - Abendroth, K

AU - Parisi, G

AU - Banzer, D

AU - Benevolenskaya, L I

AU - Bhalla, A K

AU - Armas, J B

AU - Cannata, J B

AU - Delmas, P D

AU - Dequeker, J

AU - Dilsen, G

AU - Eastell, R

AU - Ershova, O

AU - Falch, J A

AU - Felsch, B

AU - Havelka, S

AU - Hoszowski, K

AU - Jajic, I

AU - Kragl, U

AU - Johnell, O

AU - Vaz, A L

AU - Lorenc, R

AU - Lyritis, G

AU - Marchand, F

AU - Masaryk, P

AU - Matthis, C

AU - Miazgowski, T

AU - Pols, H A P

AU - Poor, G

AU - Rapado, A

AU - Raspe, H H

AU - Reid, D M

AU - Reisinger, W

AU - Janott, J

AU - Scheidt-Nave, C

AU - Stepan, J

AU - Todd, C

AU - Weber, K

AU - Woolf, A D

AU - Ambrecht, G

AU - Gowin, W

AU - Felsenberg, D

AU - Lunt, M

AU - Kanis, J A

AU - Reeve, J

AU - Silman, A J

AU - O'Neill, T W

PY - 2001

Y1 - 2001

N2 - The presence of a vertebral deformity increases the risk of subsequent spinal deformities. The aim of this analysis was to determine whether the presence of vertebral deformity predicts incident hip and other limb fractures. Six thousand three hundred and forty-four men and 6788 women aged 50 years and over were recruited from population registers in 31 European centers and followed prospectively for a median of 3 years. All subjects had radiographs performed at baseline and the presence of vertebral deformity was assessed using established morphometric methods. Incident limb fractures which occurred during the follow- up period were ascertained by annual postal questionnaire and confirmed by radiographs, review of medical records and personal interview. During a total of 40348 person-years of follow-up, 138 men and 391 women sustained a limb fracture, Amongst the women, after adjustment for age, prevalent vertebral deformity was a strong predictor of incident hip fracture, (rate ratio (RR) = 4.5; 95% CI 2.1-9.4) and a weak predictor of 'other' limb fractures (RR = 1.6; 95% CI 1.1-2.4), though not distal forearm fracture (RR = 1.0; 95% CI 0.6-1.6). The predictive risk increased with increasing number of prevalent deformities, particularly for subsequent hip fracture: for two or more deformities, RIE = 7.2 (95% CI 3.0-17.3). Amongst men, vertebral deformity was not associated with an increased risk of incident limb fracture though there was a nonsignificant trend toward an increased risk of hip fracture with increasing number of deformities. In summary, prevalent radiographic vertebral deformities in women are a strong predictor of hip fracture, and to a lesser extent humerus and 'other' limb fractures; however, they do not predict distal forearm fractures.

AB - The presence of a vertebral deformity increases the risk of subsequent spinal deformities. The aim of this analysis was to determine whether the presence of vertebral deformity predicts incident hip and other limb fractures. Six thousand three hundred and forty-four men and 6788 women aged 50 years and over were recruited from population registers in 31 European centers and followed prospectively for a median of 3 years. All subjects had radiographs performed at baseline and the presence of vertebral deformity was assessed using established morphometric methods. Incident limb fractures which occurred during the follow- up period were ascertained by annual postal questionnaire and confirmed by radiographs, review of medical records and personal interview. During a total of 40348 person-years of follow-up, 138 men and 391 women sustained a limb fracture, Amongst the women, after adjustment for age, prevalent vertebral deformity was a strong predictor of incident hip fracture, (rate ratio (RR) = 4.5; 95% CI 2.1-9.4) and a weak predictor of 'other' limb fractures (RR = 1.6; 95% CI 1.1-2.4), though not distal forearm fracture (RR = 1.0; 95% CI 0.6-1.6). The predictive risk increased with increasing number of prevalent deformities, particularly for subsequent hip fracture: for two or more deformities, RIE = 7.2 (95% CI 3.0-17.3). Amongst men, vertebral deformity was not associated with an increased risk of incident limb fracture though there was a nonsignificant trend toward an increased risk of hip fracture with increasing number of deformities. In summary, prevalent radiographic vertebral deformities in women are a strong predictor of hip fracture, and to a lesser extent humerus and 'other' limb fractures; however, they do not predict distal forearm fractures.

KW - incidence

KW - limb fracture

KW - osteoporosis

KW - vertebral deformity

KW - vertebral osteoporosis

KW - RISK-FACTORS

KW - WRIST FRACTURES

KW - BONE MASS

KW - WOMEN

KW - MEN

KW - POPULATION

KW - WELL

M3 - Article

VL - 12

SP - 85

EP - 90

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

ER -