Abstract
Incubation of rat hippocampal slices in the presence of the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation (LTP). Slices co-incubated with both HU-210 (100 nM) and the cannabinoid antagonist, SR141716A (100 nM), exhibited tetanically induced LTP, comparable to control slices. Intriguingly, coincubation with HU-210 and SR141716A prevented the induction of the early, short-term phase of LTP.
Original language | English |
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Pages (from-to) | 869-870 |
Number of pages | 2 |
Journal | British Journal of Pharmacology |
Volume | 115 |
Issue number | 6 |
Publication status | Published - Jul 1995 |
Keywords
- CANNABINOID
- LONG-TERM POTENTIATION
- HIPPOCAMPUS
- SR141716A
- MEMORY
- cannabinoid
- long-term potentiation
- hippocampus