PREVENTION BY THE CANNABINOID ANTAGONIST, SR141716A, OF CANNABINOID-MEDIATED BLOCKADE OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE

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Abstract

Incubation of rat hippocampal slices in the presence of the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation (LTP). Slices co-incubated with both HU-210 (100 nM) and the cannabinoid antagonist, SR141716A (100 nM), exhibited tetanically induced LTP, comparable to control slices. Intriguingly, coincubation with HU-210 and SR141716A prevented the induction of the early, short-term phase of LTP.

Original languageEnglish
Pages (from-to)869-870
Number of pages2
JournalBritish Journal of Pharmacology
Volume115
Issue number6
Publication statusPublished - Jul 1995

Keywords

  • CANNABINOID
  • LONG-TERM POTENTIATION
  • HIPPOCAMPUS
  • SR141716A
  • MEMORY
  • cannabinoid
  • long-term potentiation
  • hippocampus

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