PREVENTION BY THE CANNABINOID ANTAGONIST, SR141716A, OF CANNABINOID-MEDIATED BLOCKADE OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE

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Abstract

Incubation of rat hippocampal slices in the presence of the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation (LTP). Slices co-incubated with both HU-210 (100 nM) and the cannabinoid antagonist, SR141716A (100 nM), exhibited tetanically induced LTP, comparable to control slices. Intriguingly, coincubation with HU-210 and SR141716A prevented the induction of the early, short-term phase of LTP.

Original languageEnglish
Pages (from-to)869-870
Number of pages2
JournalBritish Journal of Pharmacology
Volume115
Issue number6
Publication statusPublished - Jul 1995

Keywords

  • CANNABINOID
  • LONG-TERM POTENTIATION
  • HIPPOCAMPUS
  • SR141716A
  • MEMORY
  • cannabinoid
  • long-term potentiation
  • hippocampus

Cite this

@article{cac95ad6e1224df68b0315c20434525d,
title = "PREVENTION BY THE CANNABINOID ANTAGONIST, SR141716A, OF CANNABINOID-MEDIATED BLOCKADE OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE",
abstract = "Incubation of rat hippocampal slices in the presence of the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation (LTP). Slices co-incubated with both HU-210 (100 nM) and the cannabinoid antagonist, SR141716A (100 nM), exhibited tetanically induced LTP, comparable to control slices. Intriguingly, coincubation with HU-210 and SR141716A prevented the induction of the early, short-term phase of LTP.",
keywords = "CANNABINOID, LONG-TERM POTENTIATION, HIPPOCAMPUS, SR141716A, MEMORY, cannabinoid, long-term potentiation, hippocampus",
author = "Diana Collins and Pertwee, {Roger Guy} and Davies, {Stephen Nicholas}",
year = "1995",
month = "7",
language = "English",
volume = "115",
pages = "869--870",
journal = "British Journal of Pharmacology",
issn = "0007-1188",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - PREVENTION BY THE CANNABINOID ANTAGONIST, SR141716A, OF CANNABINOID-MEDIATED BLOCKADE OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE

AU - Collins, Diana

AU - Pertwee, Roger Guy

AU - Davies, Stephen Nicholas

PY - 1995/7

Y1 - 1995/7

N2 - Incubation of rat hippocampal slices in the presence of the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation (LTP). Slices co-incubated with both HU-210 (100 nM) and the cannabinoid antagonist, SR141716A (100 nM), exhibited tetanically induced LTP, comparable to control slices. Intriguingly, coincubation with HU-210 and SR141716A prevented the induction of the early, short-term phase of LTP.

AB - Incubation of rat hippocampal slices in the presence of the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU-210) (100 nM) prevented the induction of long-term potentiation (LTP). Slices co-incubated with both HU-210 (100 nM) and the cannabinoid antagonist, SR141716A (100 nM), exhibited tetanically induced LTP, comparable to control slices. Intriguingly, coincubation with HU-210 and SR141716A prevented the induction of the early, short-term phase of LTP.

KW - CANNABINOID

KW - LONG-TERM POTENTIATION

KW - HIPPOCAMPUS

KW - SR141716A

KW - MEMORY

KW - cannabinoid

KW - long-term potentiation

KW - hippocampus

M3 - Article

VL - 115

SP - 869

EP - 870

JO - British Journal of Pharmacology

JF - British Journal of Pharmacology

SN - 0007-1188

IS - 6

ER -