Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers

Claire J. Stocker, Ed Wargent, Jacqueline O'Dowd, Claire Cornick, John R. Speakman, Jonathan R. S. Arch, Michael A. Cawthorne

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Absence of leptin is known to disrupt the development of energy balance regulatory mechanisms. We investigated whether administration of leptin to normally nourished rats affects energy balance in their offspring. Leptin (2 mg.kg(-1).day(-1)) was administered from day 14 of pregnancy and throughout lactation. Male and female offspring were fed either on chow or on high-fat diets that elicited similar levels of obesity in the sexes from 6 wk to 15 mo of age. Treatment of the dams with leptin prevented diet-induced increases in the rate of weight gain, retroperitoneal fat pad weight, area under the intraperitoneal glucose tolerance curve, and fasting plasma insulin concentration in female offspring. In the male offspring, the diet-induced increase in weight gain was prevented and increased fat pad weight was reduced. Energy intake per rat was higher in response to the obesogenic diet in male offspring of saline-treated but not leptin-treated dams. A similar trend was seen in 3-mo-old female offspring. Energy expenditure at 3 mo of age was higher for a given body weight in female offspring of leptin-treated compared with saline-treated dams when these animals were fed on the obesogenic diet. A similar trend was seen for male rats fed on the obesogenic diet. Thus leptin levels during pregnancy and lactation can affect the development of energy balance regulatory systems in their offspring.

Original languageEnglish
Pages (from-to)R1810-R1818
Number of pages9
JournalAmerican Journal of Physiology-Regulatory Integrative and Comparative Physiology
Volume292
Issue number5
Early online date18 Jan 2007
DOIs
Publication statusPublished - May 2007

Keywords

  • additional energy balance
  • energy expenditure
  • catch-up growth
  • low-birth-weight
  • body-weight
  • food-intake
  • insulin-resistance
  • maternal smoking
  • arcuate nucleus
  • breast-milk
  • lactation
  • metabolism

Cite this

Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers. / Stocker, Claire J.; Wargent, Ed; O'Dowd, Jacqueline; Cornick, Claire; Speakman, John R.; Arch, Jonathan R. S.; Cawthorne, Michael A.

In: American Journal of Physiology-Regulatory Integrative and Comparative Physiology, Vol. 292, No. 5, 05.2007, p. R1810-R1818.

Research output: Contribution to journalArticle

Stocker, Claire J. ; Wargent, Ed ; O'Dowd, Jacqueline ; Cornick, Claire ; Speakman, John R. ; Arch, Jonathan R. S. ; Cawthorne, Michael A. / Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers. In: American Journal of Physiology-Regulatory Integrative and Comparative Physiology. 2007 ; Vol. 292, No. 5. pp. R1810-R1818.
@article{0f77f1bdc0c74f99b59c1ef98ed0a8a8,
title = "Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers",
abstract = "Absence of leptin is known to disrupt the development of energy balance regulatory mechanisms. We investigated whether administration of leptin to normally nourished rats affects energy balance in their offspring. Leptin (2 mg.kg(-1).day(-1)) was administered from day 14 of pregnancy and throughout lactation. Male and female offspring were fed either on chow or on high-fat diets that elicited similar levels of obesity in the sexes from 6 wk to 15 mo of age. Treatment of the dams with leptin prevented diet-induced increases in the rate of weight gain, retroperitoneal fat pad weight, area under the intraperitoneal glucose tolerance curve, and fasting plasma insulin concentration in female offspring. In the male offspring, the diet-induced increase in weight gain was prevented and increased fat pad weight was reduced. Energy intake per rat was higher in response to the obesogenic diet in male offspring of saline-treated but not leptin-treated dams. A similar trend was seen in 3-mo-old female offspring. Energy expenditure at 3 mo of age was higher for a given body weight in female offspring of leptin-treated compared with saline-treated dams when these animals were fed on the obesogenic diet. A similar trend was seen for male rats fed on the obesogenic diet. Thus leptin levels during pregnancy and lactation can affect the development of energy balance regulatory systems in their offspring.",
keywords = "additional energy balance, energy expenditure, catch-up growth, low-birth-weight, body-weight, food-intake, insulin-resistance, maternal smoking, arcuate nucleus, breast-milk, lactation, metabolism",
author = "Stocker, {Claire J.} and Ed Wargent and Jacqueline O'Dowd and Claire Cornick and Speakman, {John R.} and Arch, {Jonathan R. S.} and Cawthorne, {Michael A.}",
year = "2007",
month = "5",
doi = "10.1152/ajpregu.00676.2006",
language = "English",
volume = "292",
pages = "R1810--R1818",
journal = "American Journal of Physiology-Regulatory Integrative and Comparative Physiology",
issn = "0363-6119",
publisher = "American Physiological Society",
number = "5",

}

TY - JOUR

T1 - Prevention of diet-induced obesity and impaired glucose tolerance in rats following administration of leptin to their mothers

AU - Stocker, Claire J.

AU - Wargent, Ed

AU - O'Dowd, Jacqueline

AU - Cornick, Claire

AU - Speakman, John R.

AU - Arch, Jonathan R. S.

AU - Cawthorne, Michael A.

PY - 2007/5

Y1 - 2007/5

N2 - Absence of leptin is known to disrupt the development of energy balance regulatory mechanisms. We investigated whether administration of leptin to normally nourished rats affects energy balance in their offspring. Leptin (2 mg.kg(-1).day(-1)) was administered from day 14 of pregnancy and throughout lactation. Male and female offspring were fed either on chow or on high-fat diets that elicited similar levels of obesity in the sexes from 6 wk to 15 mo of age. Treatment of the dams with leptin prevented diet-induced increases in the rate of weight gain, retroperitoneal fat pad weight, area under the intraperitoneal glucose tolerance curve, and fasting plasma insulin concentration in female offspring. In the male offspring, the diet-induced increase in weight gain was prevented and increased fat pad weight was reduced. Energy intake per rat was higher in response to the obesogenic diet in male offspring of saline-treated but not leptin-treated dams. A similar trend was seen in 3-mo-old female offspring. Energy expenditure at 3 mo of age was higher for a given body weight in female offspring of leptin-treated compared with saline-treated dams when these animals were fed on the obesogenic diet. A similar trend was seen for male rats fed on the obesogenic diet. Thus leptin levels during pregnancy and lactation can affect the development of energy balance regulatory systems in their offspring.

AB - Absence of leptin is known to disrupt the development of energy balance regulatory mechanisms. We investigated whether administration of leptin to normally nourished rats affects energy balance in their offspring. Leptin (2 mg.kg(-1).day(-1)) was administered from day 14 of pregnancy and throughout lactation. Male and female offspring were fed either on chow or on high-fat diets that elicited similar levels of obesity in the sexes from 6 wk to 15 mo of age. Treatment of the dams with leptin prevented diet-induced increases in the rate of weight gain, retroperitoneal fat pad weight, area under the intraperitoneal glucose tolerance curve, and fasting plasma insulin concentration in female offspring. In the male offspring, the diet-induced increase in weight gain was prevented and increased fat pad weight was reduced. Energy intake per rat was higher in response to the obesogenic diet in male offspring of saline-treated but not leptin-treated dams. A similar trend was seen in 3-mo-old female offspring. Energy expenditure at 3 mo of age was higher for a given body weight in female offspring of leptin-treated compared with saline-treated dams when these animals were fed on the obesogenic diet. A similar trend was seen for male rats fed on the obesogenic diet. Thus leptin levels during pregnancy and lactation can affect the development of energy balance regulatory systems in their offspring.

KW - additional energy balance

KW - energy expenditure

KW - catch-up growth

KW - low-birth-weight

KW - body-weight

KW - food-intake

KW - insulin-resistance

KW - maternal smoking

KW - arcuate nucleus

KW - breast-milk

KW - lactation

KW - metabolism

U2 - 10.1152/ajpregu.00676.2006

DO - 10.1152/ajpregu.00676.2006

M3 - Article

VL - 292

SP - R1810-R1818

JO - American Journal of Physiology-Regulatory Integrative and Comparative Physiology

JF - American Journal of Physiology-Regulatory Integrative and Comparative Physiology

SN - 0363-6119

IS - 5

ER -