Prevention of mitochondrial diseases: a hope through assisted reproductive technologies

Research output: Contribution to journalArticle

Abstract

Mitochondrial diseases are a heterogenic and poorly studied group of diseases, considered serious in most cases and currently without treatment. Although assisted reproduction proposed strategies to prevent them, such as pre-implantation genetic diagnosis, these techniques are not sufficiently successful. However, the recent publication of two assistedreproduction techniques – meiotic spindle transfer in nonhuman primates and pronuclear transfer in humans – generate a clear ray of hope for the prevention of these diseases. This review analyzes the characteristics and meaning of these new findings and their future clinical implications.

Translated title of the contributionPrevention of mitochondrial diseases: a hope through assisted reproductive technologies
Original languageSpanish
Pages (from-to)172-5
Number of pages4
JournalGaceta Medica de Mexico
Volume147
Issue number2
Publication statusPublished - 30 Apr 2011

Fingerprint

Mitochondrial Diseases
Assisted Reproductive Techniques
Genetic Techniques
Spindle Apparatus
Primates
Reproduction
Therapeutics
Mitochondrial Replacement Therapy

Keywords

  • Humans
  • Mitochondrial Diseases
  • Nuclear Transfer Techniques
  • Reproductive Techniques, Assisted
  • English Abstract
  • Journal Article
  • Review

Cite this

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title = "Prevenci{\'o}n de enfermedades mitocondriales: una esperanza a trav{\'e}s del uso de t{\'e}cnicas de reproducci{\'o}n asistida",
abstract = "Mitochondrial diseases are a heterogenic and poorly studied group of diseases, considered serious in most cases and currently without treatment. Although assisted reproduction proposed strategies to prevent them, such as pre-implantation genetic diagnosis, these techniques are not sufficiently successful. However, the recent publication of two assistedreproduction techniques – meiotic spindle transfer in nonhuman primates and pronuclear transfer in humans – generate a clear ray of hope for the prevention of these diseases. This review analyzes the characteristics and meaning of these new findings and their future clinical implications.",
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journal = "Gaceta Medica de Mexico",
issn = "0016-3813",
publisher = "Academia Nacional de Medicina",
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AU - Pina Aguilar, Raul Eduardo

PY - 2011/4/30

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N2 - Mitochondrial diseases are a heterogenic and poorly studied group of diseases, considered serious in most cases and currently without treatment. Although assisted reproduction proposed strategies to prevent them, such as pre-implantation genetic diagnosis, these techniques are not sufficiently successful. However, the recent publication of two assistedreproduction techniques – meiotic spindle transfer in nonhuman primates and pronuclear transfer in humans – generate a clear ray of hope for the prevention of these diseases. This review analyzes the characteristics and meaning of these new findings and their future clinical implications.

AB - Mitochondrial diseases are a heterogenic and poorly studied group of diseases, considered serious in most cases and currently without treatment. Although assisted reproduction proposed strategies to prevent them, such as pre-implantation genetic diagnosis, these techniques are not sufficiently successful. However, the recent publication of two assistedreproduction techniques – meiotic spindle transfer in nonhuman primates and pronuclear transfer in humans – generate a clear ray of hope for the prevention of these diseases. This review analyzes the characteristics and meaning of these new findings and their future clinical implications.

KW - Humans

KW - Mitochondrial Diseases

KW - Nuclear Transfer Techniques

KW - Reproductive Techniques, Assisted

KW - English Abstract

KW - Journal Article

KW - Review

M3 - Article

VL - 147

SP - 172

EP - 175

JO - Gaceta Medica de Mexico

JF - Gaceta Medica de Mexico

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