Primary pulmonary osteosarcoma: case report and molecular analysis

Andrea .d. Chapman, S. C. Pritchard, W. W. Yap, Patrick Hugh Rooney, J. S. Cockburn, M. C. Nicolson, K.m. Kerr, H. L. McLeod, A. W. Hutcheon

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Abstract

    BACKGROUND. Primary pulmonary osteosarcoma is an extremely rare malignancy. To date, only 12 cases have been reported, with a high mortality rate. The authors report on a newly diagnosed patient and describe investigations that were performed using immunohistochemistry and comparative genomic hybridization (CGH).

    METHODS. The clinical course of a woman age 37 years is presented. Along with routine histologic examination, immunohistochemistry was used to demonstrate differentiation-associated proteins, oncoproteins, and other markers; CGH analysis for genomic alterations; and histochemistry to demonstrate alkaline phosphatase activity.

    RESULTS, Immunohistochemical analysis showed Varying expression patterns using antibodies against a panel of tumor markers. Most notable was high overexpression of BCL-2 and cyclin D. CGH analysis showed that this neoplasm contained a much higher level of genetic aberrations compared with skeletal osteosarcoma.

    CONCLUSIONS. This tumor exhibited features common to skeletal osteosarcomas but also had some unique features. Genome analysis suggests that this tumor has several genetic aberrations in common with extraskeletal osteosarcoma. The novel regions of instability identified within the tumor genome may contribute toward the unique tumor phenotype and relative chemoresistance. (C) 2001 American Cancer Society.

    Original languageEnglish
    Pages (from-to)779-784
    Number of pages5
    JournalCancer
    Volume91
    Issue number4
    DOIs
    Publication statusPublished - 2001

    Keywords

    • primary pulmonary osteosarcoma
    • comparative genome hybridization
    • BCL-2
    • cyclin D1
    • COMPARATIVE GENOMIC HYBRIDIZATION
    • EXTRASKELETAL OSTEOSARCOMA
    • POOR-PROGNOSIS
    • HUMAN SARCOMAS
    • EXPRESSION
    • LUNG
    • IDENTIFICATION
    • PROTEIN
    • GENE
    • P53

    Cite this

    Chapman, A. . D., Pritchard, S. C., Yap, W. W., Rooney, P. H., Cockburn, J. S., Nicolson, M. C., ... Hutcheon, A. W. (2001). Primary pulmonary osteosarcoma: case report and molecular analysis. Cancer, 91(4), 779-784. https://doi.org/10.1002/1097-0142(20010215)91:4<779::AID-CNCR1064>3.0.CO;2-J

    Primary pulmonary osteosarcoma: case report and molecular analysis. / Chapman, Andrea .d.; Pritchard, S. C.; Yap, W. W.; Rooney, Patrick Hugh; Cockburn, J. S.; Nicolson, M. C.; Kerr, K.m.; McLeod, H. L.; Hutcheon, A. W.

    In: Cancer, Vol. 91, No. 4, 2001, p. 779-784.

    Research output: Contribution to journalArticle

    Chapman, AD, Pritchard, SC, Yap, WW, Rooney, PH, Cockburn, JS, Nicolson, MC, Kerr, KM, McLeod, HL & Hutcheon, AW 2001, 'Primary pulmonary osteosarcoma: case report and molecular analysis', Cancer, vol. 91, no. 4, pp. 779-784. https://doi.org/10.1002/1097-0142(20010215)91:4<779::AID-CNCR1064>3.0.CO;2-J
    Chapman, Andrea .d. ; Pritchard, S. C. ; Yap, W. W. ; Rooney, Patrick Hugh ; Cockburn, J. S. ; Nicolson, M. C. ; Kerr, K.m. ; McLeod, H. L. ; Hutcheon, A. W. / Primary pulmonary osteosarcoma: case report and molecular analysis. In: Cancer. 2001 ; Vol. 91, No. 4. pp. 779-784.
    @article{4e3b5cd9e572402c849ca347b67bb3b6,
    title = "Primary pulmonary osteosarcoma: case report and molecular analysis",
    abstract = "BACKGROUND. Primary pulmonary osteosarcoma is an extremely rare malignancy. To date, only 12 cases have been reported, with a high mortality rate. The authors report on a newly diagnosed patient and describe investigations that were performed using immunohistochemistry and comparative genomic hybridization (CGH).METHODS. The clinical course of a woman age 37 years is presented. Along with routine histologic examination, immunohistochemistry was used to demonstrate differentiation-associated proteins, oncoproteins, and other markers; CGH analysis for genomic alterations; and histochemistry to demonstrate alkaline phosphatase activity.RESULTS, Immunohistochemical analysis showed Varying expression patterns using antibodies against a panel of tumor markers. Most notable was high overexpression of BCL-2 and cyclin D. CGH analysis showed that this neoplasm contained a much higher level of genetic aberrations compared with skeletal osteosarcoma.CONCLUSIONS. This tumor exhibited features common to skeletal osteosarcomas but also had some unique features. Genome analysis suggests that this tumor has several genetic aberrations in common with extraskeletal osteosarcoma. The novel regions of instability identified within the tumor genome may contribute toward the unique tumor phenotype and relative chemoresistance. (C) 2001 American Cancer Society.",
    keywords = "primary pulmonary osteosarcoma, comparative genome hybridization, BCL-2, cyclin D1, COMPARATIVE GENOMIC HYBRIDIZATION, EXTRASKELETAL OSTEOSARCOMA, POOR-PROGNOSIS, HUMAN SARCOMAS, EXPRESSION, LUNG, IDENTIFICATION, PROTEIN, GENE, P53",
    author = "Chapman, {Andrea .d.} and Pritchard, {S. C.} and Yap, {W. W.} and Rooney, {Patrick Hugh} and Cockburn, {J. S.} and Nicolson, {M. C.} and K.m. Kerr and McLeod, {H. L.} and Hutcheon, {A. W.}",
    year = "2001",
    doi = "10.1002/1097-0142(20010215)91:4<779::AID-CNCR1064>3.0.CO;2-J",
    language = "English",
    volume = "91",
    pages = "779--784",
    journal = "Cancer",
    issn = "0008-543X",
    publisher = "Wiley",
    number = "4",

    }

    TY - JOUR

    T1 - Primary pulmonary osteosarcoma: case report and molecular analysis

    AU - Chapman, Andrea .d.

    AU - Pritchard, S. C.

    AU - Yap, W. W.

    AU - Rooney, Patrick Hugh

    AU - Cockburn, J. S.

    AU - Nicolson, M. C.

    AU - Kerr, K.m.

    AU - McLeod, H. L.

    AU - Hutcheon, A. W.

    PY - 2001

    Y1 - 2001

    N2 - BACKGROUND. Primary pulmonary osteosarcoma is an extremely rare malignancy. To date, only 12 cases have been reported, with a high mortality rate. The authors report on a newly diagnosed patient and describe investigations that were performed using immunohistochemistry and comparative genomic hybridization (CGH).METHODS. The clinical course of a woman age 37 years is presented. Along with routine histologic examination, immunohistochemistry was used to demonstrate differentiation-associated proteins, oncoproteins, and other markers; CGH analysis for genomic alterations; and histochemistry to demonstrate alkaline phosphatase activity.RESULTS, Immunohistochemical analysis showed Varying expression patterns using antibodies against a panel of tumor markers. Most notable was high overexpression of BCL-2 and cyclin D. CGH analysis showed that this neoplasm contained a much higher level of genetic aberrations compared with skeletal osteosarcoma.CONCLUSIONS. This tumor exhibited features common to skeletal osteosarcomas but also had some unique features. Genome analysis suggests that this tumor has several genetic aberrations in common with extraskeletal osteosarcoma. The novel regions of instability identified within the tumor genome may contribute toward the unique tumor phenotype and relative chemoresistance. (C) 2001 American Cancer Society.

    AB - BACKGROUND. Primary pulmonary osteosarcoma is an extremely rare malignancy. To date, only 12 cases have been reported, with a high mortality rate. The authors report on a newly diagnosed patient and describe investigations that were performed using immunohistochemistry and comparative genomic hybridization (CGH).METHODS. The clinical course of a woman age 37 years is presented. Along with routine histologic examination, immunohistochemistry was used to demonstrate differentiation-associated proteins, oncoproteins, and other markers; CGH analysis for genomic alterations; and histochemistry to demonstrate alkaline phosphatase activity.RESULTS, Immunohistochemical analysis showed Varying expression patterns using antibodies against a panel of tumor markers. Most notable was high overexpression of BCL-2 and cyclin D. CGH analysis showed that this neoplasm contained a much higher level of genetic aberrations compared with skeletal osteosarcoma.CONCLUSIONS. This tumor exhibited features common to skeletal osteosarcomas but also had some unique features. Genome analysis suggests that this tumor has several genetic aberrations in common with extraskeletal osteosarcoma. The novel regions of instability identified within the tumor genome may contribute toward the unique tumor phenotype and relative chemoresistance. (C) 2001 American Cancer Society.

    KW - primary pulmonary osteosarcoma

    KW - comparative genome hybridization

    KW - BCL-2

    KW - cyclin D1

    KW - COMPARATIVE GENOMIC HYBRIDIZATION

    KW - EXTRASKELETAL OSTEOSARCOMA

    KW - POOR-PROGNOSIS

    KW - HUMAN SARCOMAS

    KW - EXPRESSION

    KW - LUNG

    KW - IDENTIFICATION

    KW - PROTEIN

    KW - GENE

    KW - P53

    U2 - 10.1002/1097-0142(20010215)91:4<779::AID-CNCR1064>3.0.CO;2-J

    DO - 10.1002/1097-0142(20010215)91:4<779::AID-CNCR1064>3.0.CO;2-J

    M3 - Article

    VL - 91

    SP - 779

    EP - 784

    JO - Cancer

    JF - Cancer

    SN - 0008-543X

    IS - 4

    ER -