Primary pulmonary osteosarcoma: case report and molecular analysis

Andrea .d. Chapman, S. C. Pritchard, W. W. Yap, Patrick Hugh Rooney, J. S. Cockburn, M. C. Nicolson, K.m. Kerr, H. L. McLeod, A. W. Hutcheon

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    Abstract

    BACKGROUND. Primary pulmonary osteosarcoma is an extremely rare malignancy. To date, only 12 cases have been reported, with a high mortality rate. The authors report on a newly diagnosed patient and describe investigations that were performed using immunohistochemistry and comparative genomic hybridization (CGH).

    METHODS. The clinical course of a woman age 37 years is presented. Along with routine histologic examination, immunohistochemistry was used to demonstrate differentiation-associated proteins, oncoproteins, and other markers; CGH analysis for genomic alterations; and histochemistry to demonstrate alkaline phosphatase activity.

    RESULTS, Immunohistochemical analysis showed Varying expression patterns using antibodies against a panel of tumor markers. Most notable was high overexpression of BCL-2 and cyclin D. CGH analysis showed that this neoplasm contained a much higher level of genetic aberrations compared with skeletal osteosarcoma.

    CONCLUSIONS. This tumor exhibited features common to skeletal osteosarcomas but also had some unique features. Genome analysis suggests that this tumor has several genetic aberrations in common with extraskeletal osteosarcoma. The novel regions of instability identified within the tumor genome may contribute toward the unique tumor phenotype and relative chemoresistance. (C) 2001 American Cancer Society.

    Original languageEnglish
    Pages (from-to)779-784
    Number of pages5
    JournalCancer
    Volume91
    Issue number4
    DOIs
    Publication statusPublished - 2001

    Keywords

    • primary pulmonary osteosarcoma
    • comparative genome hybridization
    • BCL-2
    • cyclin D1
    • COMPARATIVE GENOMIC HYBRIDIZATION
    • EXTRASKELETAL OSTEOSARCOMA
    • POOR-PROGNOSIS
    • HUMAN SARCOMAS
    • EXPRESSION
    • LUNG
    • IDENTIFICATION
    • PROTEIN
    • GENE
    • P53

    Cite this

    Chapman, A. . D., Pritchard, S. C., Yap, W. W., Rooney, P. H., Cockburn, J. S., Nicolson, M. C., Kerr, K. M., McLeod, H. L., & Hutcheon, A. W. (2001). Primary pulmonary osteosarcoma: case report and molecular analysis. Cancer, 91(4), 779-784. https://doi.org/10.1002/1097-0142(20010215)91:4<779::AID-CNCR1064>3.0.CO;2-J