Primürstruktur der Adipokinetischen Hormone II von Heuschrecken

Translated title of the contribution: Primary Structures of Locust Adipokinetic Hormones II

Karl Siegert, Peter Morgan, William Mordue

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

Adipokinetic hormones II from corpora cardiaca of the locusts Schistocerca gregaria and Locusta migratoria, respectively, have been isolated and their primary structures elucidated. Both octapeptides are N-terminally blocked by a 5-oxoproline (pyroglutamate) residue and had to be cleaved by 5-oxoprolyl-peptidase to make them available for the Edman degradation method carried out with a gas-phase sequencer. The C- termini are blocked as both peptides are not cleaved by carboxypeptidase A; the presence of C-terminal amide groups is very likely. AKHII (S. gregaria) Glu-Leu-Asn-Phe-Ser-Thr-Gly-Trp-NHi AKHII (L. migratoria) Glu-Leu-Asn-Phe-Ser-Ala-Gly-Trp-NH2.

Translated title of the contributionPrimary Structures of Locust Adipokinetic Hormones II
Original languageUndefined/Unknown
Pages (from-to)723-728
Number of pages6
JournalBiological Chemistry Hoppe-Seyler
Volume366
Issue number2
DOIs
Publication statusPublished - 1 Jan 1985

Keywords

  • AKHII
  • gas-phase sequencing
  • Locusts
  • primary structure
  • reversed-phase high-performance liquid chromatography

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