Prior clopidogrel use and outcome of acute coronary syndrome

Roy L Soiza; Stephen J Leslie

doi:10.1016/j.ijcard.2005.07.081

Prior clopidogrel use and outcome of acute coronary syndrome

Roy L Soiza, Stephen J Leslie

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

BACKGROUND: Prior aspirin use has been associated with poorer outcome in acute coronary syndrome, and forms part of the TIMI Risk Score. It is not known if prior use of clopidogrel is associated with similar risk.

AIM: To assess if prior clopidogrel use is associated with higher risk in acute coronary syndrome.

PARTICIPANTS: Participants were 869 consecutive admissions to a Scottish district general hospital with suspected acute coronary syndrome.

METHODS: Incidence of death, recurrent myocardial infarction or urgent percutaneous intervention at 2 weeks was recorded. Odds ratios for sub-groups on clopidogrel, aspirin or neither were calculated.

RESULTS: Odds ratios were: clopidogrel 1.46 (95% ci 0.62-3.33), aspirin 1.09 (95% ci 0.64-1.85), neither 0.91 (95% ci 0.53-1.54).

CONCLUSION: No definite association was shown between clopidogrel use and outcome but there was a trend towards increased risk of major acute coronary events.

Original language	English
Pages (from-to)	313-4
Number of pages	2
Journal	International Journal of Cardiology
Volume	111
Issue number	2
DOIs	https://doi.org/10.1016/j.ijcard.2005.07.081
Publication status	Published - 10 Aug 2006

Keywords

Aspirin
Coronary Disease
Humans
Odds Ratio
Platelet Aggregation Inhibitors
Ticlopidine
Treatment Outcome
Letter

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10.1016/j.ijcard.2005.07.081

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title = "Prior clopidogrel use and outcome of acute coronary syndrome",

abstract = "BACKGROUND: Prior aspirin use has been associated with poorer outcome in acute coronary syndrome, and forms part of the TIMI Risk Score. It is not known if prior use of clopidogrel is associated with similar risk.AIM: To assess if prior clopidogrel use is associated with higher risk in acute coronary syndrome.PARTICIPANTS: Participants were 869 consecutive admissions to a Scottish district general hospital with suspected acute coronary syndrome.METHODS: Incidence of death, recurrent myocardial infarction or urgent percutaneous intervention at 2 weeks was recorded. Odds ratios for sub-groups on clopidogrel, aspirin or neither were calculated.RESULTS: Odds ratios were: clopidogrel 1.46 (95% ci 0.62-3.33), aspirin 1.09 (95% ci 0.64-1.85), neither 0.91 (95% ci 0.53-1.54).CONCLUSION: No definite association was shown between clopidogrel use and outcome but there was a trend towards increased risk of major acute coronary events.",

keywords = "Aspirin, Coronary Disease, Humans, Odds Ratio, Platelet Aggregation Inhibitors, Ticlopidine, Treatment Outcome, Letter",

author = "Soiza, {Roy L} and Leslie, {Stephen J}",

year = "2006",

month = aug,

day = "10",

doi = "10.1016/j.ijcard.2005.07.081",

language = "English",

volume = "111",

pages = "313--4",

journal = "International Journal of Cardiology",

issn = "0167-5273",

publisher = "Elsevier Ireland Ltd",

number = "2",

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TY - JOUR

T1 - Prior clopidogrel use and outcome of acute coronary syndrome

AU - Soiza, Roy L

AU - Leslie, Stephen J

PY - 2006/8/10

Y1 - 2006/8/10

N2 - BACKGROUND: Prior aspirin use has been associated with poorer outcome in acute coronary syndrome, and forms part of the TIMI Risk Score. It is not known if prior use of clopidogrel is associated with similar risk.AIM: To assess if prior clopidogrel use is associated with higher risk in acute coronary syndrome.PARTICIPANTS: Participants were 869 consecutive admissions to a Scottish district general hospital with suspected acute coronary syndrome.METHODS: Incidence of death, recurrent myocardial infarction or urgent percutaneous intervention at 2 weeks was recorded. Odds ratios for sub-groups on clopidogrel, aspirin or neither were calculated.RESULTS: Odds ratios were: clopidogrel 1.46 (95% ci 0.62-3.33), aspirin 1.09 (95% ci 0.64-1.85), neither 0.91 (95% ci 0.53-1.54).CONCLUSION: No definite association was shown between clopidogrel use and outcome but there was a trend towards increased risk of major acute coronary events.

AB - BACKGROUND: Prior aspirin use has been associated with poorer outcome in acute coronary syndrome, and forms part of the TIMI Risk Score. It is not known if prior use of clopidogrel is associated with similar risk.AIM: To assess if prior clopidogrel use is associated with higher risk in acute coronary syndrome.PARTICIPANTS: Participants were 869 consecutive admissions to a Scottish district general hospital with suspected acute coronary syndrome.METHODS: Incidence of death, recurrent myocardial infarction or urgent percutaneous intervention at 2 weeks was recorded. Odds ratios for sub-groups on clopidogrel, aspirin or neither were calculated.RESULTS: Odds ratios were: clopidogrel 1.46 (95% ci 0.62-3.33), aspirin 1.09 (95% ci 0.64-1.85), neither 0.91 (95% ci 0.53-1.54).CONCLUSION: No definite association was shown between clopidogrel use and outcome but there was a trend towards increased risk of major acute coronary events.

KW - Aspirin

KW - Coronary Disease

KW - Humans

KW - Odds Ratio

KW - Platelet Aggregation Inhibitors

KW - Ticlopidine

KW - Treatment Outcome

KW - Letter

U2 - 10.1016/j.ijcard.2005.07.081

DO - 10.1016/j.ijcard.2005.07.081

M3 - Article

C2 - 16266761

SN - 0167-5273

VL - 111

SP - 313

EP - 314

JO - International Journal of Cardiology

JF - International Journal of Cardiology

IS - 2

ER -

Prior clopidogrel use and outcome of acute coronary syndrome

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Keywords

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