Prior clopidogrel use and outcome of acute coronary syndrome

Roy L Soiza, Stephen J Leslie

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

BACKGROUND: Prior aspirin use has been associated with poorer outcome in acute coronary syndrome, and forms part of the TIMI Risk Score. It is not known if prior use of clopidogrel is associated with similar risk.

AIM: To assess if prior clopidogrel use is associated with higher risk in acute coronary syndrome.

PARTICIPANTS: Participants were 869 consecutive admissions to a Scottish district general hospital with suspected acute coronary syndrome.

METHODS: Incidence of death, recurrent myocardial infarction or urgent percutaneous intervention at 2 weeks was recorded. Odds ratios for sub-groups on clopidogrel, aspirin or neither were calculated.

RESULTS: Odds ratios were: clopidogrel 1.46 (95% ci 0.62-3.33), aspirin 1.09 (95% ci 0.64-1.85), neither 0.91 (95% ci 0.53-1.54).

CONCLUSION: No definite association was shown between clopidogrel use and outcome but there was a trend towards increased risk of major acute coronary events.

Original languageEnglish
Pages (from-to)313-4
Number of pages2
JournalInternational Journal of Cardiology
Volume111
Issue number2
DOIs
Publication statusPublished - 10 Aug 2006

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clopidogrel
Acute Coronary Syndrome
Aspirin
Odds Ratio
District Hospitals
General Hospitals
Myocardial Infarction

Keywords

  • Aspirin
  • Coronary Disease
  • Humans
  • Odds Ratio
  • Platelet Aggregation Inhibitors
  • Ticlopidine
  • Treatment Outcome
  • Letter

Cite this

Prior clopidogrel use and outcome of acute coronary syndrome. / Soiza, Roy L; Leslie, Stephen J.

In: International Journal of Cardiology, Vol. 111, No. 2, 10.08.2006, p. 313-4.

Research output: Contribution to journalArticle

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N2 - BACKGROUND: Prior aspirin use has been associated with poorer outcome in acute coronary syndrome, and forms part of the TIMI Risk Score. It is not known if prior use of clopidogrel is associated with similar risk.AIM: To assess if prior clopidogrel use is associated with higher risk in acute coronary syndrome.PARTICIPANTS: Participants were 869 consecutive admissions to a Scottish district general hospital with suspected acute coronary syndrome.METHODS: Incidence of death, recurrent myocardial infarction or urgent percutaneous intervention at 2 weeks was recorded. Odds ratios for sub-groups on clopidogrel, aspirin or neither were calculated.RESULTS: Odds ratios were: clopidogrel 1.46 (95% ci 0.62-3.33), aspirin 1.09 (95% ci 0.64-1.85), neither 0.91 (95% ci 0.53-1.54).CONCLUSION: No definite association was shown between clopidogrel use and outcome but there was a trend towards increased risk of major acute coronary events.

AB - BACKGROUND: Prior aspirin use has been associated with poorer outcome in acute coronary syndrome, and forms part of the TIMI Risk Score. It is not known if prior use of clopidogrel is associated with similar risk.AIM: To assess if prior clopidogrel use is associated with higher risk in acute coronary syndrome.PARTICIPANTS: Participants were 869 consecutive admissions to a Scottish district general hospital with suspected acute coronary syndrome.METHODS: Incidence of death, recurrent myocardial infarction or urgent percutaneous intervention at 2 weeks was recorded. Odds ratios for sub-groups on clopidogrel, aspirin or neither were calculated.RESULTS: Odds ratios were: clopidogrel 1.46 (95% ci 0.62-3.33), aspirin 1.09 (95% ci 0.64-1.85), neither 0.91 (95% ci 0.53-1.54).CONCLUSION: No definite association was shown between clopidogrel use and outcome but there was a trend towards increased risk of major acute coronary events.

KW - Aspirin

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