Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication

Rachel Swainson, R D Rogers, B J Sahakian, B A Summers, C E Polkey, T W Robbins

Research output: Contribution to journalArticle

360 Citations (Scopus)

Abstract

Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPT) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic ic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses - based on disease severity and possible deleterious effects of medication - are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)596-612
Number of pages17
JournalNeuropsychologia
Volume38
Issue number5
Publication statusPublished - 2000

Keywords

  • visual discrimination
  • concurrent
  • dopamine
  • reward
  • cortical
  • SPATIAL WORKING-MEMORY
  • PREFRONTAL CORTEX
  • EXCITOTOXIC LESIONS
  • BASAL GANGLIA
  • VISUAL-DISCRIMINATION
  • INFEROTEMPORAL CORTEX
  • HUNTINGTONS-DISEASE
  • VISUOSPATIAL MEMORY
  • PERFORMANCE
  • LEVODOPA

Cite this

Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication. / Swainson, Rachel; Rogers, R D ; Sahakian, B J ; Summers, B A ; Polkey, C E ; Robbins, T W .

In: Neuropsychologia, Vol. 38, No. 5, 2000, p. 596-612.

Research output: Contribution to journalArticle

@article{681f69fb85dc4d27af347ea8bfb7a114,
title = "Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication",
abstract = "Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPT) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic ic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses - based on disease severity and possible deleterious effects of medication - are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning. (C) 2000 Elsevier Science Ltd. All rights reserved.",
keywords = "visual discrimination, concurrent, dopamine, reward, cortical, SPATIAL WORKING-MEMORY, PREFRONTAL CORTEX, EXCITOTOXIC LESIONS, BASAL GANGLIA, VISUAL-DISCRIMINATION, INFEROTEMPORAL CORTEX, HUNTINGTONS-DISEASE, VISUOSPATIAL MEMORY, PERFORMANCE, LEVODOPA",
author = "Rachel Swainson and Rogers, {R D} and Sahakian, {B J} and Summers, {B A} and Polkey, {C E} and Robbins, {T W}",
year = "2000",
language = "English",
volume = "38",
pages = "596--612",
journal = "Neuropsychologia",
issn = "0028-3932",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication

AU - Swainson, Rachel

AU - Rogers, R D

AU - Sahakian, B J

AU - Summers, B A

AU - Polkey, C E

AU - Robbins, T W

PY - 2000

Y1 - 2000

N2 - Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPT) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic ic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses - based on disease severity and possible deleterious effects of medication - are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning. (C) 2000 Elsevier Science Ltd. All rights reserved.

AB - Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPT) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic ic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses - based on disease severity and possible deleterious effects of medication - are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning. (C) 2000 Elsevier Science Ltd. All rights reserved.

KW - visual discrimination

KW - concurrent

KW - dopamine

KW - reward

KW - cortical

KW - SPATIAL WORKING-MEMORY

KW - PREFRONTAL CORTEX

KW - EXCITOTOXIC LESIONS

KW - BASAL GANGLIA

KW - VISUAL-DISCRIMINATION

KW - INFEROTEMPORAL CORTEX

KW - HUNTINGTONS-DISEASE

KW - VISUOSPATIAL MEMORY

KW - PERFORMANCE

KW - LEVODOPA

M3 - Article

VL - 38

SP - 596

EP - 612

JO - Neuropsychologia

JF - Neuropsychologia

SN - 0028-3932

IS - 5

ER -