Probabilistic learning and reversal deficits in patients with Parkinson's disease or frontal or temporal lobe lesions: possible adverse effects of dopaminergic medication

Rachel Swainson, R D Rogers, B J Sahakian, B A Summers, C E Polkey, T W Robbins

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Abstract

Three groups of patients with Parkinson's disease (PD) - mild, unmedicated (UPD), mild, medicated (MPD) and severe, medicated (SPT) - and patients with lesions of the frontal lobe (FLL) or temporal lobe (TLL) were compared with matched controls on the learning and reversal of probabilistic ic and two-pair concurrent colour discriminations. Both of the cortical lesion groups showed reversal deficits, with no increase in perseverative responding. The UPD group, although impaired on a spatial recognition task, showed intact discrimination learning and reversal; the MPD and SPD patients showed non-perseverative reversal impairments on both reversal tasks. Two hypotheses - based on disease severity and possible deleterious effects of medication - are offered to explain the reversal impairments of the PD patients and the results are discussed in terms of the role of dopamine in reward-based learning. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)596-612
Number of pages17
JournalNeuropsychologia
Volume38
Issue number5
Publication statusPublished - 2000

Keywords

  • visual discrimination
  • concurrent
  • dopamine
  • reward
  • cortical
  • SPATIAL WORKING-MEMORY
  • PREFRONTAL CORTEX
  • EXCITOTOXIC LESIONS
  • BASAL GANGLIA
  • VISUAL-DISCRIMINATION
  • INFEROTEMPORAL CORTEX
  • HUNTINGTONS-DISEASE
  • VISUOSPATIAL MEMORY
  • PERFORMANCE
  • LEVODOPA

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